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Cited by 31Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging

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Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy

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Wang, Shuntao, Zeng, Ning, Zhang, Qi, Chen, Mingzhu, Huang, Qinqin·2022·Frontiers in Oncology
DOI 10.3389/fonc.2022.888855PMC PMC9289279
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Abstract

Sonosensitizer-mediated sonodynamic therapy (SDT) has emerged as a promising anti-tumor strategy. However, this strategy of continuous oxygen consumption further exacerbates the hypoxic tumor microenvironment, which limits its therapeutic efficacy. In this study, we designed a multifunctional hydrogel (PB+Ce6@Hy) that simultaneously co-delivers nanozyme prussian blue (PB) and sonosensitizer chlorin e6 (Ce6) for the realization of photothermal therapy (PTT) and enhanced SDT. When the hydrogel reaches the tumor tissue through local injection, the 808 nm laser can induce the hydrogel to warm up and soften, thereby triggering the release of PB and Ce6. PB can interact with endogenous H 2 O 2in situ and generate sufficient oxygen to promote the Ce6-mediated SDT effect. Besides, due to the good encapsulation ability of the hydrogel, the nanomaterials can be released in a controlled manner by changing laser parameter, irradiation time, etc. The experimental results show that the PB+Ce6@Hy system we developed can generate a large amount of reactive oxygen species (ROS), which can be combined with the photothermal effect to kill tumor cells, as a result, tumor proliferation has been adequately inhibited. This combined PTT/SDT dynamic strategy provides a new perspective for Ce6-induced cancer therapy, showing great potential for clinical application.

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  • PB + Ce6@Hy hydrogel combined treatment of PTT and SDT inhibits the growth of breast cancer.

    “PB exploits catalase activity to interact with endogenous H2O2 to generate extra O2 and promote the Ce6-mediated SDT effect, allowing the combined treatment of PTT and SDT to inhibit the growth of breast cancer (Fig. 8C) [114].”

    From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [114]

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Metadata

Authors
Wang, S., Zeng, N., Zhang, Q., Chen, M., & Huang, Q.
Affiliations
  • Second Affiliated Hospital of Zhengzhou University (CN)
  • Tongji Hospital (CN)
  • Zhongnan Hospital of Wuhan University (CN)
Corresponding author
Huang, Qinqin
ORCID
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2022-07-04
Volume
12
Pages
888855-888855
ISSN
2234-943X (ISSN-L)
DOI
10.3389/fonc.2022.888855
PMC
PMC9289279
OpenAlex
W4283796810
Cited by
31
References
1
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 4 · 2022: 3
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
Keywords
nanozymes, Prussian blue, chlorin e6, sonosensitizer, hydrogels, sonodynamic therapy, photothermal therapy, combination therapy, tumor hypoxia, reactive oxygen species, oxygen production, tumor microenvironment, cancer therapy

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