Cited by 148Phytochemicals and Antioxidant ActivitiesDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Role of natural phenolics in hepatoprotection: A mechanistic review and analysis of regulatory network of associated genes

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Saha, Priyanka, Talukdar, Anupam Das, Nath, Rajat, Sarker, Satyajit D., Nahar, Lutfun, Sahu, Jagajjit, Choudhury, Manabendra Dutta·2019·Frontiers in Pharmacology

Abstract

The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situation. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease, long term alcohol abuse and chronic use of medications can cause persistent injury in which regenerative capacity eventually becomes dysfunctional resulting in hepatic scaring and cirrhosis. Despite the recent therapeutic advances and significant development of modern medicine, hepatic diseases remain a health problem worldwide. Thus, the search for the new therapeutic agents to treat liver disease is still in demand. Many synthetic drugs have been demonstrated to be strong radical scavengers, but they are also carcinogenic and cause liver damage. Present day various hepatic problems are encountered with number of synthetic and plant based drugs. Nexavar (sorafenib) is a chemotherapeutic medication used to treat advanced renal cell carcinoma associated with several side effects. There are a few effective varieties of herbal preparation like Liv-52, silymarin and Stronger neomin phages (SNMC) against hepatic complications. Plants are the huge repository of bioactive secondary metabolites viz; phenol, flavonoid, alkaloid etc. In this review we will try to present exclusive study on phenolics with its mode of action mitigating liver associated complications. And also its future prospects as new drug lead.

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Authors
Saha, P., Talukdar, A. D., Nath, R., Sarker, S. D., Nahar, L., Sahu, J., & Choudhury, M. D.
Affiliations
  • Assam University (IN)
  • Liverpool John Moores University (GB)
  • Banaras Hindu University (IN)
Corresponding author
Talukdar, Anupam Das
Venue
Frontiers in Pharmacology
Published
2019-05-24
Volume
10
Pages
509-509
ISSN
1663-9812 (ISSN-L)
OpenAlex
W2944990167
Cited by
148
References
215
Citations by year
2026: 15 · 2025: 18 · 2024: 22 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 9 · 2019: 3 · 2017: 1
FWCI
1.71
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Liverpool John Moores University (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Assam University, Silchar
  • Department of Biotechnology, Ministry of Science and Technology, India
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
hepatoprotection, liver injury, liver cirrhosis, non-alcoholic fatty liver disease, viral hepatitis, drug-induced liver injury, silymarin, herbal medicine, flavonoids, plant secondary metabolites, gene regulatory networks, lead compound identification, liver regeneration

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