Like Cures Like: Pharmacological Activity of Anti-Inflammatory Lipopolysaccharides From Gut Microbiome
Open accessAbstract
Gut microbiome maintains local gut integrity and systemic host homeostasis, where optimal control of intestinal lipopolysaccharides (LPS) activity may play an important role. LPS mainly produced from gut microbiota are a group of lipid-polysaccharide chemical complexes existing in the outer membrane of Gram-negative bacteria. Traditionally, LPS mostly produced from Proteobacteria are well known for their ability in inducing strong inflammatory responses (proinflammatory LPS, abbreviated as P-LPS), leading to septic shock or even death in animals and humans. Although the basic structures and chemical properties of P-LPS derived from different bacterial species generally show similarity, subtle and differential immune activation activities are observed. On the other hand, frequently ignored, a group of LPS molecules mainly produced by certain microbiota bacteria such as Bacteroidetes show blunt or even antagonistic activity in initiating pro-inflammatory responses (anti-inflammatory LPS, abbreviated as A-LPS). In this review, besides the immune activation properties of P-LPS, we also focus on the description of anti-inflammatory effects of A-LPS, and their potential antagonistic mechanism. We address the possibility of using native or engineered A-LPS for immune modulation in prevention or even treatment of P-LPS induced chronic inflammation related diseases. Understanding the exquisite interactive relationship between structure-activity correlation of P- and A-LPS not only contributes to molecular understanding of immunomodulation and homeostasis, but also re-animates the development of novel LPS-based pharmacological strategy for prevention and therapy of chronic inflammation related diseases.
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Inflammatory LPS is produced by abnormally high Proteobacteria, and TLR4 recognizes elevated inflammatory LPS, in turn activating the MyD88-dependent NF-kappaB signaling pathway.
“Inflammatory LPS is produced by abnormally high Proteobacteria, and TLR4 recognizes elevated inflammatory LPS [69], in turn activating the MyD88-dependent NF-κB signaling pathway.”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [69]
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Cites
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924 · see citing works
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.007 · Cited by 1,289 · see citing works
Bacterial lipopolysaccharides and innate immunity
Alexander, C., & Rietschel, E. T. (2001) · Journal of Endotoxin Research · doi:10.1179/096805101101532675 · Cited by 1,173 · see citing works
Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation
Vanaja, S. K., Russo, A. J., Behl, B., Banerjee, I., Yankova, M. P., Deshmukh, S. D., & Rathinam, V. A. K. (2016) · Cell · doi:10.1016/j.cell.2016.04.015 · Cited by 730 · see citing works
Yoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.033714 · Cited by 619 · see citing works
O-antigen structural variation: mechanisms and possible roles in animal/plant–microbe interactions
Lerouge, I., & Vanderleyden, J. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00597.x · Cited by 504 · see citing works
The endotoxin hypothesis of neurodegeneration
Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457 · see citing works
Fink, M. P. (2014) · Virulence · doi:10.4161/viru.26083 · Cited by 391 · see citing works
Recent Advances in Lipopolysaccharide Recognition Systems
Mazgaeen, L., & Gurung, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020379 · Cited by 382 · see citing works
Structure and function: Lipid A modifications in commensals and pathogens
Steimle, A., Autenrieth, I. B., & Frick, J.-S. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.001 · Cited by 357 · see citing works
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
d’Hennezel, E., Abubucker, S., Murphy, L. O., & Cullen, T. W. (2017) · mSystems · doi:10.1128/msystems.00046-17 · Cited by 324 · see citing works
E5531, a Pure Endotoxin Antagonist of High Potency
Christ, W. J., Asano, O., Robidoux, A. L. C., Perez, M., Wang, Y., Dubuc, G. R., Gavin, W. E., Hawkins, L. D., McGuinness, P. D., Mullarkey, M. A., et al. (1995) · Science · doi:10.1126/science.7701344 · Cited by 319 · see citing works
Hersoug, L., Møller, P., & Loft, S. H. (2015) · Obesity Reviews · doi:10.1111/obr.12370 · Cited by 294 · see citing works
Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
Fuke, N., Nagata, N., Suganuma, H., & Ota, T. (2019) · Nutrients · doi:10.3390/nu11102277 · Cited by 269 · see citing works
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x46565 · Cited by 268 · see citing works
Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Faner, R., Rojas, M., MacNee, W., & Agustí, A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0282pp · Cited by 268 · see citing works
Endotoxins and Other Sepsis Triggers
Opal, S. M. (2010) · Contributions to nephrology · doi:10.1159/000315915 · Cited by 258 · see citing works
Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair
Davey, A., McAuley, D. F., & O’Kane, C. M. (2011) · European Respiratory Journal · doi:10.1183/09031936.00032111 · Cited by 249 · see citing works
Modulating the innate immune response by combinatorial engineering of endotoxin
Needham, B. D., Carroll, S. M., Giles, D. K., Georgiou, G., Whiteley, M., & Trent, M. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218080110 · Cited by 232 · see citing works
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1177/09680519050110040701 · Cited by 231 · see citing works
Distribution of Core Oligosaccharide Types in Lipopolysaccharides from Escherichia coli
Amor, K. L., Heinrichs, D. E., Frirdich, E., Ziebell, K. A., Johnson, R. P., & Whitfield, C. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1116-1124.2000 · Cited by 192 · see citing works
Coats, S. R., Jones, J. W., Christopher, T., Braham, P. H., Bainbridge, B. W., To, T. T., Goodlett, D. R., Ernst, R. K., & Darveau, R. P. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01349.x · Cited by 177 · see citing works
Coats, S. R., Pham, T.-T. T., Bainbridge, B. W., Reife, R. A., & Darveau, R. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4490 · Cited by 169 · see citing works
Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies
Barochia, A., Solomon, S., Cui, X., Natanson, C., & Eichacker, P. Q. (2011) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2011.558190 · Cited by 169 · see citing works
Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14
Kim, S. J., & Kim, H. M. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.2.011 · Cited by 153 · see citing works
Reife, R. A., Coats, S. R., Alqutub, M. N., Dixon, D. M., Braham, P. A., Billharz, R. J., Howald, W. N., & Darveau, R. P. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00672.x · Cited by 142 · see citing works
Nativel, B., Couret, D., Giraud, P., Meilhac, O., d’Hellencourt, C. L., Viranaïcken, W., & Silva, C. R. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-16190-y · Cited by 141 · see citing works
Tan, H., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09617-1 · Cited by 140 · see citing works
Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis
Pfalzgraff, A., & Weindl, G. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.01.001 · Cited by 139 · see citing works
Mechanisms of Immune Signaling in Colitis-Associated Cancer
Waldner, M. J., & Neurath, M. F. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.11.006 · Cited by 120 · see citing works
Asti, C., Ruggieri, V., Porzio, S., et al. (2000) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2000.0231 · Cited by 108 · see citing works
Lipopolysaccharide biogenesis and transport at the outer membrane of Gram-negative bacteria.
Sperandeo, P., Martorana, A., & Polissi, A. (2017) · Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.10.006 · Cited by 108 · see citing works
Chen, L.-W., Chen, P.-H., & Hsu, C.-M. (2011) · Shock · doi:10.1097/shk.0b013e3182184ee7 · Cited by 104 · see citing works
Kobayashi, S., Fujinawa, R., Ota, F., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0074oc · Cited by 102 · see citing works
The modulatory effects of lipopolysaccharide‐stimulated B cells on differential T‐cell polarization
Xu, H. M., Liew, L. N., Kuo, I.-C., Huang, C. H., Goh, D. L. M., & Chua, K. Y. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02832.x · Cited by 100 · see citing works
Coats, S. R., Berezow, A. B., To, T. T., Jain, S., Bainbridge, B. W., Banani, K. P., & Darveau, R. P. (2010) · Infection and Immunity · doi:10.1128/iai.00937-10 · Cited by 97 · see citing works
Weak Agonistic LPS Restores Intestinal Immune Homeostasis
Steimle, A., Michaelis, L., Lorenzo, F. D., Kliem, T., Münzner, T., Maerz, J. K., Schäfer, A., Lange, A., Parusel, R., Gronbach, K., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.07.007 · Cited by 97 · see citing works
Rallabhandi, P., Awomoyi, A. A., Thomas, K. E., Phalipon, A., Fujimoto, Y., Fukase, K., Kusumoto, S., Qureshi, N., Sztein, M. B., & Vogel, S. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.1139 · Cited by 87 · see citing works
The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron
Jacobson, A. N., Choudhury, B., & Fischbach, M. A. (2018) · mBio · doi:10.1128/mbio.02289-17 · Cited by 87 · see citing works
Endotoxicity of Lipopolysaccharide as a Determinant of T-Cell−Mediated Colitis Induction in Mice
Gronbach, K., Flade, I., Holst, O., Lindner, B., Ruscheweyh, H., Wittmann, A., Menz, S., Schwiertz, A., Adam, P., Stecher, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.033 · Cited by 85 · see citing works
Berezow, A. B., Ernst, R. K., Coats, S. R., Braham, P. H., Karimi-Naser, L. M., & Darveau, R. P. (2009) · Microbial Pathogenesis · doi:10.1016/j.micpath.2009.04.015 · Cited by 84 · see citing works
Browning, D. F., Wells, T. J., França, F. L. S., Morris, F. C., Sevastsyanovich, Y. R., Bryant, J. A., Johnson, M. D., Lund, P. A., Cunningham, A. F., Hobman, J. L., et al. (2013) · Molecular Microbiology · doi:10.1111/mmi.12144 · Cited by 83 · see citing works
Fedele, G., Nasso, M., Spensieri, F., Palazzo, R., Frasca, L., Watanabe, M., & Ausiello, C. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.208 · Cited by 81 · see citing works
Microbiome and Mental Health, Specifically as It Relates to Adolescents
Simkin, D. R. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1075-3 · Cited by 79 · see citing works
Cytokines in chronic respiratory diseases
Atamas, S. P., Chapoval, S. P., & Keegan, A. D. (2013) · F1000 Biology Reports · doi:10.3410/b5-3 · Cited by 77 · see citing works
Savov, J. D., Brass, D. M., Lawson, B. L., McElvania, E., Walker, J. K. L., & Schwartz, D. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00014.2005 · Cited by 73 · see citing works
Arribas, B., Rodríguez‐Cabezas, M. E., Camuesco, D., Comalada, M., Bailón, E., Utrilla, P., Nieto, A., Concha, Á., Zarzuelo, A., & Gálvez, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00270.x · Cited by 73 · see citing works
Lorenzo, F. D., Kubik, Ł., Oblak, A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.649087 · Cited by 66 · see citing works
Coats, S. R., Do, C. T., Karimi-Naser, L. M., Braham, P. H., & Darveau, R. P. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00859.x · Cited by 65 · see citing works
O-antigen and Core Carbohydrate of Vibrio fischeri Lipopolysaccharide
Post, D. M. B., Yu, L. P., Krasity, B. C., Choudhury, B., Mandel, M. J., Brennan, C. A., Ruby, E. G., McFall‐Ngai, M., Gibson, B. W., & Apicella, M. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324012 · Cited by 65 · see citing works
The Dual Role of Lipopolysaccharide as Effector and Target Molecule
Wiese, A., Brandenburg, K., Ulmer, A. J., Seydel, U., & Müller‐Loennies, S. (1999) · Biological Chemistry · doi:10.1515/bc.1999.097 · Cited by 62 · see citing works
Influence of Intestinal Microbiota on Body Weight Gain: a Narrative Review of the Literature
Cardinelli, C. D. S., Sala, P. C., Alves, C. C., Torrinhas, R. S., & Waitzberg, D. L. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1525-2 · Cited by 62 · see citing works
Association between HMGB1 and COPD: A Systematic Review
Gangemi, S., Casciaro, M., Trapani, G. D., Quartuccio, S., Navarra, M., Pioggia, G., & Imbalzano, E. (2015) · Mediators of Inflammation · doi:10.1155/2015/164913 · Cited by 57 · see citing works
Oblak, A., & Jerala, R. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.034 · Cited by 55 · see citing works
Güttsches, A., Löseke, S., Zähringer, U., Sonnenborn, U., Enders, C., Gatermann, S. G., & Bufe, A. (2011) · Innate Immunity · doi:10.1177/1753425910396251 · Cited by 52 · see citing works
Modulation of Symbiont Lipid A Signaling by Host Alkaline Phosphatases in the Squid-Vibrio Symbiosis
Rader, B. A., Kremer, N., Apicella, M. A., et al. (2012) · mBio · doi:10.1128/mbio.00093-12 · Cited by 44 · see citing works
Chilton, P. M., Hadel, D. M., To, T. T., Mitchell, T. C., & Darveau, R. P. (2013) · Infection and Immunity · doi:10.1128/iai.01150-12 · Cited by 44 · see citing works
NISHIZAWA, T., Inagawa, H., Oshima, H., et al. (1992) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.40.479 · Cited by 42 · see citing works
The Lipid A from Vibrio fischeri Lipopolysaccharide
Phillips, N. J., Adin, D. M., Stabb, E. V., McFall‐Ngai, M., Apicella, M. A., & Gibson, B. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.239475 · Cited by 42 · see citing works
Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects
Aul, R., Armstrong, J., Duvoix, A., Lomas, D. A., Hayes, B., Miller, B. E., Jagger, C. P., & Singh, D. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04287.x · Cited by 34 · see citing works
Chantratita, N., Tandhavanant, S., Myers, N. D., Seal, S., Arayawichanont, A., Kliangsa-ad, A., Hittle, L. E., Ernst, R. K., Emond, M. J., Wurfel, M. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081617 · Cited by 34 · see citing works
Hulina, A., Heijink, I. H., Jonker, M. R., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.09.010 · Cited by 32 · see citing works
Biological Activity of Bacteroides Lipopolysaccharide—Reappraisal
Poxton, I. R., & Edmond, D. M. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.supplement_2.s149 · Cited by 31 · see citing works
Gupta, V., Banyard, A., Mullan, A. F., et al. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12546 · Cited by 27 · see citing works
Korneev, K. V., Kondakova, A. N., Sviriaeva, E. N., Mitkin, N. A., Palmigiano, A., Kruglov, A., Telegin, G. B., Drutskaya, M. S., Sturiale, L., Garozzo, D., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00058 · Cited by 25 · see citing works
A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia
Döring, C., Regen, T., Gertig, U., van Rossum, D., Winkler, A., Saiepour, N., Brück, W., Hanisch, U., & Jáňová, H. (2017) · Glia · doi:10.1002/glia.23151 · Cited by 24 · see citing works
Gardères, J., Bedoux, G., Koutsouveli, V., Crequer, S., Desriac, F., & Pennec, G. L. (2015) · Marine Drugs · doi:10.3390/md13084985 · Cited by 23 · see citing works
Maeshima, N., Evans-Atkinson, T., Hajjar, A. M., & Fernandez, R. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.653881 · Cited by 17 · see citing works
Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness
Hajjar, A. M., Ernst, R. K., Yi, J., Yam, C. S., & Miller, S. I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186308 · Cited by 16 · see citing works
Tsutsumi‐Ishii, Y., Shimada, K., Daida, H., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm129 · Cited by 13 · see citing works
Kadowaki, T., Ohno, S., Taniguchi, Y., et al. (2013) · PubMed · Cited by 10 · see citing works
Komori, T., Saito, K., Sawa, N., et al. (2015) · PubMed · Cited by 10 · see citing works
Alexandre, A., Maria, K. D., Alexandre, P. D., et al. (2018) · Joint Research Centre (European Commission) · doi:10.2760/17381 · Cited by 9 · see citing works
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Pan, W., Zhao, J., Wu, J., Xu, D., Meng, X., Jiang, P., Shi, H., Ge, X., Yang, X., Hu, M., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01471-8 · Cited by 113 · see citing works
Guo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82 · see citing works
- Authors
- Lin, T.-L., Shu, C.-C., Chen, Y.-M., Lu, J.-J., Wu, T.-S., Lai, W.-F., Tzeng, C.-M., Lai, H.-C., & Lu, C.-C.
- Affiliations
- Chang Gung University (TW)
- National Taiwan University Hospital (TW)
- National Taiwan Ocean University (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Xiamen University (CN)
- Chang Gung University of Science and Technology (TW)
- Fu Jen Catholic University (TW)
- Corresponding author
- Lai, Hsin-Chih
- Lu, Chia-Chen
- ORCID
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2020-04-30
- Volume
- 11
- Pages
- 554-554
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC7212368
- OpenAlex
- W3023197304
- Cited by
- 143
- References
- 74
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 39 · 2023: 20 · 2022: 31 · 2021: 15 · 2020: 2 · 2019: 1
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chang Gung University
- Ministry of Education, India
- Chang Gung Medical Foundation
- Ministry of Science and Technology, Taiwan (MOST108-2321-B182-002, MOST108-2320-B030-005)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- lipopolysaccharide, gut microbiota, Bacteroidetes, Proteobacteria, Gram-negative bacteria, immunomodulation, chronic inflammation, structure-activity relationship, septic shock, inflammation-related diseases
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