The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
Open accessAbstract
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of CXCL12 and its receptors subsequently induces downstream signaling pathways with broad effects on chemotaxis, cell proliferation, migration, and gene expression. Accumulating evidence suggests that the CXCL12/CXCR4/CXCR7 axis plays a pivotal role in tumor development, survival, angiogenesis, metastasis, and tumor microenvironment. In addition, this chemokine axis promotes chemoresistance in cancer therapy via complex crosstalk with other pathways. Multiple small molecules targeting CXCR4/CXCR7 have been developed and used for preclinical and clinical cancer treatment. In this review, we describe the roles of the CXCL12/CXCR4/CXCR7 axis in cancer progression and summarize strategies to develop novel targeted cancer therapies.
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4 retracted
The Role of CXCR7/RDC1 as a Chemokine Receptor for CXCL12/SDF-1 in Prostate Cancer
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RetractedA Glycolytic Mechanism Regulating an Angiogenic Switch in Prostate Cancer
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RetractedEffect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo
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RetractedLiao, A., Shi, R., Jiang, Y., Tian, S., Li, P., Song, F., Qu, Y., Li, J., Yun, H., & Yang, X. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9006-0 · Cited by 40
RetractedNew functions for the matrix metalloproteinases in cancer progression
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Involvement of chemokine receptors in breast cancer metastasis
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
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Cited by
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
“chemokine receptor (CXCR) 4 serves as a crucial mediator in numerous physiological and pathological processes, including inflammatory responses of the immune systems, regulation of hematopoiesis, induction of angiogenesis, as well as tumor invasion and metastasis.(37) Mice with disrupted CXCR4 receptors experience a r…”
BackgroundRadiotheranostics in oncology: Making precision medicine possible
Aboagye, E. O., Barwick, T. D., & Haberkorn, U. (2023) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21768 · Cited by 131
Jang, B.-Y., Shin, M., Han, D.-H., & Sung, J.-S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112627 · Cited by 19
Ho, K. K. Y., Srivastava, S., Kinnunen, P. C., Garikipati, K., Luker, G. D., & Luker, K. E. (2023) · Bioengineering · doi:10.3390/bioengineering10020269 · Cited by 8
Zhang, R., Liu, Q., Lyu, C., Gao, X., & Ma, W. (2023) · Biomedicines · doi:10.3390/biomedicines11030914 · Cited by 3
Metadata
- Authors
- Shi, Y., Riese, D. J., & Shen, J.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2020-12-08
- Volume
- 11
- Pages
- 574667-574667
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W3111751350
- Cited by
- 336
- References
- 184
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shi, Y., Riese, D. J., & Shen, J. (2020). The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2020.574667
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