The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
Open accessAbstract
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides. The intracellular imbalance between oxidant and antioxidant due to the abnormal expression of multiple redox active enzymes will promote the produce of reactive oxygen species (ROS). So far, a few pathways and regulators have been discovered to regulate ferroptosis. In particular, the cystine/glutamate antiporter (System X c−), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System X c−/GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System X c−/GSH/GPX4 axis. This review aims to present the current understanding of the mechanism of ferroptosis based on the System X c−/GSH/GPX4 axis in the treatment of drug-resistant solid tumors.
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3 retracted
Ferroptosis is governed by differential regulation of transcription in liver cancer
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RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: molecular mechanisms and health implications
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Cited by
GPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Liao, Y., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 426
Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy
Liu, P., Hao, L., Liu, M., & Hu, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1161472 · Cited by 58
Lam, C.-S., Xia, Y.-X., Chen, B.-S., Du, Y.-X., Liu, K.-L., & Zhang, H.-J. (2023) · Nutrients · doi:10.3390/nu15133006 · Cited by 28
Guo, Y., Zhao, J., Liu, X., Lu, P., Liang, F., Wang, X., Wu, J., & Hai, Y. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10165-3 · Cited by 17
Metadata
- Authors
- Li, F.-J., Long, H.-Z., Zhou, Z.-W., Luo, H.-Y., Xu, S.-G., & Gao, L.-C.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2022-08-29
- Volume
- 13
- Pages
- 910292-910292
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W4293537664
- Cited by
- 438
- References
- 280
- FWCI
- 45.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, F.-J., Long, H.-Z., Zhou, Z.-W., Luo, H.-Y., Xu, S.-G., & Gao, L.-C. (2022). System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2022.910292
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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