The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
GPX4, ferroptosis, and diseases
Open accessAbstract
GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body. Ferroptosis, a form of iron-dependent non-apoptotic cell death, has gained considerable attention in recent years due to its involvement in multiple pathological processes. GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several diseases, including sepsis, nervous system diseases, ischemia reperfusion injury, cardiovascular diseases, and cancer. This review comprehensively explores the regulatory roles and impacts of GPX4 and ferroptosis in the development and progression of these diseases, with the aim of providing insights for identifying potential therapeutic strategies in the future.
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Cites
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Ferroptosis: mechanisms, biology and role in disease
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Ferroptosis: molecular mechanisms and health implications
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Ferroptosis: process and function
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Cited by
Guo, Y., Zhao, J., Liu, X., Lu, P., Liang, F., Wang, X., Wu, J., & Hai, Y. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10165-3 · Cited by 17
Metadata
- Authors
- Zhang, W., Liu, Y., Liao, Y., Zhu, C., & Zou, Z.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2024-05
- Volume
- 174
- Pages
- 116512
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4393855312
- Cited by
- 426
- References
- 226
- FWCI
- 108.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, W., Liu, Y., Liao, Y., Zhu, C., & Zou, Z. (2024). GPX4, ferroptosis, and diseases. Biomedicine & Pharmacotherapy. https://doi.org/10.1016/j.biopha.2024.116512
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
