The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
The critical roles of caveolin-1 in lung diseases
Open accessAbstract
Caveolin-1 (Cav-1), a structural and functional component in the caveolae, plays a critical role in transcytosis, endocytosis, and signal transduction. Cav-1 has been implicated in the mediation of cellular processes by interacting with a variety of signaling molecules. Cav-1 is widely expressed in the endothelial cells, smooth muscle cells, and fibroblasts in the various organs, including the lungs. The Cav-1-mediated internalization and regulation of signaling molecules participate in the physiological and pathological processes. Particularly, the MAPK, NF-κB, TGFβ/Smad, and eNOS/NO signaling pathways have been involved in the regulatory effects of Cav-1 in lung diseases. The important effects of Cav-1 on the lungs indicate that Cav-1 can be a potential target for the treatment of lung diseases. A Cav-1 scaffolding domain peptide CSP7 targeting Cav-1 has been developed. In this article, we mainly discuss the structure of Cav-1 and its critical roles in lung diseases, such as pneumonia, acute lung injury (ALI), asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension, pulmonary fibrosis, and lung cancer.
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“Caveolin-1 protein (Cav-1) is a structural protein that plays a critical role in regulating lung repair and cellular movement by restoring pathways that both promote epithelial health and halt fibrosis in the lung7–9.”
From Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study (2026) · cites this paper as [9]
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1 retracted
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RetractedThe role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
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Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
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Caveolae as plasma membrane sensors, protectors and organizers
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Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain
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PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.
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Role of inflammation in endothelial responses in Pulmonary Hypertension
Wang, A., Qin, P., Zhang, J., Gong, S.-X., Zhang, F., Liang, N., Yang, Y., & Jiang, Z. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118206 · Cited by 9
Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells
Chen, T., Xu, Y., Yang, F., Pan, Y., Ji, N., Li, J., Zeng, X. Y., Chen, Q., Jiang, L., & Shen, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111874 · Cited by 9
Elshal, M., Hamdi, A., Khalil, I. T., Arafa, E. A., Althobaiti, M. M., Arab, H. H., & Haikal, A. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117414 · Cited by 2
Todorović, P., Maglica, M., Kelam, N., Filipović, N., Rizikalo, A., Perutina, I., Mišković, J., Katsuyama, Y., & Vukojević, K. (2025) · Life · doi:10.3390/life15091395 · Cited by 2
Metadata
- Authors
- Fan, J., Zheng, S., Wang, M., & Yuan, X.
- Affiliations
- First Affiliated Hospital of Gannan Medical University (CN)
- Corresponding author
- Yuan, Xiaoliang
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2024-09-24
- Volume
- 15
- Pages
- 1417834-1417834
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC11458383
- OpenAlex
- W4402753012
- Cited by
- 21
- References
- 218
- Citations by year
- 2026: 14 · 2025: 6 · 2024: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Keywords
- caveolin-1, caveolae, lung disease, MAPK signaling, NF-κB signaling, TGF-β/Smad signaling, pneumonia, acute lung injury, asthma, chronic obstructive pulmonary disease, pulmonary hypertension, pulmonary fibrosis, lung cancer
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