The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, Taro; Akira, Shizuo

doi:10.1038/ni.1863

Cited by 9,304Immune Response and InflammationInflammasome and immune disordersImmunotherapy and Immune Responses

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, Taro, Akira, Shizuo·2010·Nature Immunology

DOI 10.1038/ni.1863

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Abstract

The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.

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The adaptive immune system can recognize mitochondria.
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From Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations (2019) · cites this paper as [32]
For the initial detection of microbes, the immune system utilizes pattern-recognition receptors such as TLRs to activate MyD88-dependent signaling and ultimately activate NF-κB.
“For the initial detection of microbes, the immune system utilizes pattern-recognition receptors (PRRs), such as TLRs to activate MyD88-dependent signaling and ultimately activate NF-κB (324).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [324]

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Authors: Kawai, T., & Akira, S.
Affiliations: Immunology Frontier Research Center, The University of Osaka (JP)
Corresponding author: Akira, Shizuo
ORCID: Kawai, Taro
Akira, Shizuo
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-04-20
Volume: 11
Issue: 5
Pages: 373-384
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.1863
OpenAlex: W2109491705
Cited by: 9,304
References: 13
Citations by year: 2026: 553 · 2025: 545 · 2024: 542 · 2023: 525 · 2022: 554 · 2021: 661 · 2020: 654 · 2019: 622 · 2018: 558 · 2017: 568 · 2016: 611 · 2015: 588 · 2014: 622 · 2013: 575 · 2012: 568
FWCI: 42.97
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
National Institutes of Health (AI070167)
National Institute of Allergy and Infectious Diseases (P01AI070167)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Toll-like receptors, pattern recognition receptors, innate immunity, host defense, autoimmunity, inflammatory diseases, pathogen recognition
MeSH terms: Animals, Autoimmune Diseases, Humans, Immunity, Innate, Nucleic Acids, Nucleoproteins, Signal Transduction, Toll-Like Receptors, Host-Pathogen Interactions, Adaptive Immunity

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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