Viscoelastic Networks: Forming Cells and Tissues
Open accessAbstract
Spatiotemporal changes in viscoelasticity are a key component of the morphogenesis of living systems. Experimental and theoretical findings suggest that cellular- and tissue-scale viscoelasticity can be understood as a collective property emerging from macromolecular and cellular interactions, respectively. Linking the changes in the structural or material properties of cells and tissues, such as material phase transitions, to the microscopic interactions of their constituents, is still a challenge both at the experimental and theoretical level. In this review, we summarize work on the viscoelastic nature of cytoskeletal, extracellular and cellular networks. We then conceptualize viscoelasticity as a network theory problem and discuss its applications in several biological contexts. We propose that the statistical mechanics of networks can be used in the future as a powerful framework to uncover quantitatively the biomechanical basis of viscoelasticity across scales.
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From a developmental perspective, the existence of material phases at the tissue scale defines a low-dimensional scenario of potential tissue properties and structures with obvious regulatory advantages.
“From a developmental perspective—as we already outlined in §5—the existence of material phases at the tissue scale defines a low-dimensional scenario of potential tissue properties and structures with obvious regulatory advantages [403–405].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [405]
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“From a developmental perspective—as we already outlined in §5—the existence of material phases at the tissue scale defines a low-dimensional scenario of potential tissue properties and structures with obvious regulatory advantages [403–405].”
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Matrix and cytoskeletal tension gate stretch-induced calcium signaling
Jaeger, P. K., Passini, F. S., Niederöst, B. P., Bollhalder, M., Fucentese, S. F., & Snedeker, J. G. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.014 · Cited by 2 · see citing works
Engineering tools for quantifying and manipulating forces in epithelia
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Lattice Models: Non-Conventional simulation methods for mechanobiology
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Shape Switching and Tunable Oscillations of Adaptive Droplets
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Self-citationInvestigating the structures and mechanics of single animal cells by atomic force microscopy
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Stress-hardening behaviour of biofilm streamersPreprint
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Imprinting reversible deformations on a compressed soft rod network
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Continuous Viscoelasticity Measurement of Cell Spheroids via Microfluidic Electrical Aspiration
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Self-citationHigh-Throughput Mechanomic Screening Reveals Novel Regulators of Single-Cell Mechanics
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- Authors
- Corominas-Murtra, B., & Petridou, N. I.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Petridou, Nicoletta I.
- Venue
- Frontiers in Physics
- Publisher
- Frontiers Media SA
- Published
- 2021-06-09
- Volume
- 9
- ISSN
- 2296-424X (ISSN-L)
- OpenAlex
- W3167755476
- Cited by
- 69
- References
- 161
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 19 · 2023: 4 · 2022: 11 · 2021: 3
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- viscoelasticity, biological networks, cytoskeleton, extracellular matrix, cell mechanics, tissue mechanics, morphogenesis, network theory, statistical mechanics of networks, biomechanics, collective ownership
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