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Intracellular pH regulation by acid-base transporters in mammalian neurons
Open accessAbstract
Intracellular pH (pHi) regulation in the brain is important in both physiological and physiopathological conditions because changes in pHi generally result in altered neuronal excitability. In this review, we will cover 4 major areas: (1) The effect of pHi on cellular processes in the brain, including channel activity and neuronal excitability. (2) pHi homeostasis and how it is determined by the balance between rates of acid loading (J L) and extrusion (J E). The balance between J E and J L determine steady-state pHi, as well as the ability of the cell to defend pHi in the face of extracellular acid-base disturbances (e.g., metabolic acidosis). (3) The properties and importance of members of the SLC4 and SLC9 families of acid-base transporters expressed in the brain that contribute to J L (namely the Cl-HCO3 exchanger AE3) and J E (the Na-H exchangers NHE1, NHE3, and NHE5 as well as the Na(+)- coupled HCO3 (-) transporters NBCe1, NBCn1, NDCBE, and NBCn2). (4) The effect of acid-base disturbances on neuronal function and the roles of acid-base transporters in defending neuronal pHi under physiopathologic conditions.
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Citations
Cites
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Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795
Cerebrospinal fluid secretion by the choroid plexus
Damkier, H. H., Brown, P. D., & Praetorius, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2013 · Cited by 606 · cited 1×
“Finally, we must not discount the contribution of acid-base transporters in the astrocytes (Chesler, 2003) and choroid plexus epithelia (Damkier et al., 2010a, 2013), cells that control the composition of the brain extracellular fluid and thus indirectly influence the pH of neurons.”
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Cited by
Hamm, L. L., Nakhoul, N., & Hering-Smith, K. S. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07400715 · Cited by 426
Flavor structures of charged fermions and massive neutrinos
Xing, Z.-Z. (2020) · Physics Reports · doi:10.1016/j.physrep.2020.02.001 · Cited by 294
Physiological Roles of Acid-Base Sensors
Levin, L. R., & Buck, J. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071821 · Cited by 109
Kennedy, L., Morland, C., Narum, M., Bergersen, L. H., & Rinholm, J. E. (2025) · eneuro · doi:10.1523/eneuro.0563-24.2025 · Cited by 8
Metadata
- Authors
- Ruffin, V. A., Salameh, A. I., Boron, W. F., & Parker, M. D.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 43-43
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2001858901
- Cited by
- 211
- References
- 2
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ruffin, V. A., Salameh, A. I., Boron, W. F., & Parker, M. D. (2014). Intracellular pH regulation by acid-base transporters in mammalian neurons. Frontiers in Physiology. https://doi.org/10.3389/fphys.2014.00043
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