Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults
Open accessAbstract
PURPOSE: Erythropoietin (EPO) is a renal cytokine that is primarily involved in hematopoiesis while also playing a role in non-hematopoietic tissues expressing the EPO-receptor (EPOR). The EPOR is present in human skeletal muscle. In mouse skeletal muscle, EPO stimulation can activate the AKT serine/threonine kinase 1 (AKT) signaling pathway, the main positive regulator of muscle protein synthesis. We hypothesized that a single intravenous EPO injection combined with acute resistance exercise would have a synergistic effect on skeletal muscle protein synthesis via activation of the AKT pathway. METHODS: Ten young (24.2 ± 0.9 years) and 10 older (66.6 ± 1.1 years) healthy subjects received a primed, constant infusion of [ring-13C(6)] L-phenylalanine and a single injection of 10,000 IU epoetin-beta or placebo in a double-blind randomized, cross-over design. 2 h after the injection, the subjects completed an acute bout of leg extension resistance exercise to stimulate skeletal muscle protein synthesis. RESULTS: Significant interaction effects in the phosphorylation levels of the members of the AKT signaling pathway indicated a differential activation of protein synthesis signaling in older subjects when compared to young subjects. However, EPO offered no synergistic effect on vastus lateralis mixed muscle protein synthesis rate in young or older subjects. CONCLUSIONS: Despite its ability to activate the AKT pathway in skeletal muscle, an acute EPO injection had no additive or synergistic effect on the exercise-induced activation of muscle protein synthesis or muscle protein synthesis signaling pathways.
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A sample size of 13 was calculated to minimize the risk of type II error for the primary outcome FSR (β = 0.2, α = 0.05).
“Using data from studies investigating the effects of an anabolic and catabolic stimulus (e.g., immobilization or exercise) on changes in muscle protein synthesis (Lamon et al., 2016; Paddon‐Jones et al., 2006), power analyses conducted on our primary outcome (FSR) indicated that a sample size of 13 would minimize the risk of type II error (β = 0.2,α = 0.05).”
From The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment (2021) · cites this paper as Lamon et al., 2016
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- Authors
- Lamon, S., Zacharewicz, E., Arentson-Lantz, E., Gatta, P. A. D., Ghobrial, L., Gerlinger-Romero, F., Garnham, A., Paddon-Jones, D., & Russell, A. P.
- Affiliations
- Deakin University (AU)
- Corresponding author
- Lamon, Séverine
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2016-07-08
- Volume
- 7
- Pages
- 292-292
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4937030
- OpenAlex
- W2468722352
- Cited by
- 10
- References
- 57
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2017: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion, cc-by)
- Research Bank (Australian Catholic University) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PBLAP3-131833, PBLAP3-137051)
- Deakin University (RM24071, RM24183)
- State Government of Victoria (2015 Victoria Fellowship)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- erythropoietin, skeletal muscle protein synthesis, resistance training, Akt signaling, epoetin beta, EPO receptor, aging, older adults, vastus lateralis
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