Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

Chen, Kui, Zheng, Xiaoqian, Feng, Mingchen, Li, Dongliang, Zhang, Hongqi·2017·Frontiers in Physiology

Cited by (280)

Items 201–280 of 280

  1. Dietary trimethylamine oxide alters digestibility, intestinal histopathology, and gene expression in soy fed rainbow trout (Oncorhynchus mykiss)
    Abigail B. Bockus, Madison S. Powell, Wendy M. Sealey, Phoebe Zito, Yuri Kurerov, Troy Sbisa, Javier‐Alonso Carrillo‐Longoria, T. Gibson Gaylord · 2024 · Aquaculture
  2. Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells
    Anne Krüger‐Genge, Friedrich Jung, Frank T. Hufert, Friedrich Jung, J.‐H. Küpper, Joachim Storsberg · 2020 · Clinical Hemorheology and Microcirculation
  3. Maternal High-Fat Diet Controls Offspring Kidney Health and Disease
    Hsi-Yun Liu, Chen‐Hao Lee, Chien‐Ning Hsu, You‐Lin Tain · 2023 · Nutrients
  4. Dietary Trends, Microbiome, and Cardiovascular Health: A Narrative Review
    Fabián Sanchis‐Gomar, Hélios Pareja-Galeano, José María Moya-Morales, Sergio Vázquez-González, Carme Pérez-Quilis · 2025 · Heart and Mind
  5. Emerging therapy targets to modulate microbiome-mediated effects evident in cardiovascular disease
    Dorothea Katharina Hoffelner, Tim Hendrikx · 2025 · Frontiers in Cardiovascular Medicine
  6. Association Between Gut Microbiome Alterations and Hypertension-Related Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
    Adina Cristiana Avram, Maria-Laura Craciun, Ana-Maria Pah, Florina Nicoleta Buleu, Ioana-Georgiana Cotet, Diana-Maria Mateescu, Stela Iurciuc, Simina Crișan, Oana Belei, Anda Gabriela Militaru et al. · 2025 · Microbiology Research
  7. Serum trimethylamine N-oxide levels among coronary artery disease and acute coronary syndrome patients: a systematic review and meta-analysis
    Yomna E. Dean, Samah S. Rouzan, Jose J. Loayza Pintado, Nesreen Elsayed Talat, Alaa Ramadan Hussein Mohamed, Suman Verma, Zainab Anwar Kamdi, Deepak Gir, Ahmed Helmy, Zakaria Helmy et al. · 2023 · Annals of Medicine and Surgery
  8. The Association Between the Gut Microbiome and COVID-19 Severity: The Potential Role of TMAO Produced by the Gut Microbiome
    Milad Shahini Shams Abadi, Rozita Khodashahi, Mohsen Aliakbarian, Fatemeh Beiraghdar, Mohammad‐Hassan Arjmand · 2024 · Archives of Clinical Infectious Diseases
  9. Gut Microbiota and Insulin Resistance: Understanding the Mechanism of Better Treatment of Type 2 Diabetes Mellitus
    Alsalt Al-Busaidi, Omer Alabri, Jaifar Alomairi, Ahmed Elsharaawy, Abdullah Al Lawati, Hanan Al Lawati, Srijit Das · 2024 · Current Diabetes Reviews
  10. The Effect of Red Meat Consumption on Circulating, Urinary, and Fecal Trimethylamine-N-Oxide: A Systematic Review and Narrative Synthesis of Randomized Controlled Trials
    Fatemeh Jafari, Janhavi J Damani, Kristina S. Petersen · 2025 · Advances in Nutrition
  11. Causal relationship between gut microbiota and intracranial hemorrhage: A two-sample Mendelian randomization study
    Jiameng Jia, Lin Zhou, Nan Wang, Qiang Zheng · 2024 · Medicine
  12. Gut microbiota: Implications on human health and diseases
    Tahira Farooqui · 2021 · Elsevier eBooks
  13. Trimethylamine-N-oxide (TMAO) Selectively Disrupts Endothelium-Dependent Hyperpolarization-Type Relaxations in a Time-Dependent Manner in Rat Superior Mesenteric Artery
    Abdelrahman Hamad, Melike Hacer Özkan, Serdar Uma · 2021 · Biological and Pharmaceutical Bulletin
  14. A Review of The Contribution of Gut-Dependent Microbiota Derived Marker, Trimethylamine N-oxide (TMAO), in Coronary Artery Disease
    Vasanth Konda Mohan, Melvin George · 2021 · Current Research in Nutrition and Food Science Journal
  15. Dietary Patterns and Precision Prevention of Heart Failure
    Dong D. Wang · 2019 · Journal of the American College of Cardiology
  16. Oral microbiota in cardiovascular health and disease
    Yi-Chuan Wu, Bo-Yan Chen, Sheng‐Zhong Duan · 2026 · Frontiers in Cellular and Infection Microbiology
  17. The impact of inflammation, neuromodulation, and gut microbiota on developing cardiac fibrosis and hypertension
    Michał Kozdrowicki, Piotr Szczepaniak, V. F. Kyslyi, Lorenzo Carnevale, Daniela Carnevale, Giuseppe Lembo, Tomasz Jan Guzik, Tomasz P Mikolajczyk · 2026 · Cardiovascular Research
  18. Establishing reliable blood biomarkers for trimethylamine N-oxide status in rodents: Effects of oral choline challenge, dietary choline and fasting conditions
    Ahmad Ud Din, Michael G. Sweet, Ashley M McAmis, Juanita G. Ratliff, Pon Velayutham Anandh Babu, Andrew Peter Neilson · 2025 · The Journal of Nutritional Biochemistry
  19. Upregulation of miR-33 and miR-155 by gum acacia mitigates hyperlipidaemia and inflammation but not weight increase induced by Western diet ingestion in mice
    Rasha Mohamed Hussein · 2021 · Archives of Physiology and Biochemistry
  20. Gut microbiota and the pathophysiology of cardiovascular disease
    Pavel Skok, Kristijan Skok · 2021 · Archives of Medical Science
  21. 1H NMR-based metabolomic study of the effects of yacon syrup supplementation on high-fat diet in rats
    Ana Paula Moreira Bezerra, Ana Cristina de Oliveira Monteiro Moreira, Ana Paula Dionísio, Bruna Kelly de Medeiros Andrade, Keciany Alves de Oliveira, Elenilson G. Alves Filho, Edy Sousa de Brito, Ariclécio Cunha de Oliveira, Francisco Leomar da Silva, José Diogo da Rocha Viana et al. · 2025 · International Journal of Food Science & Technology
  22. The Emerging Role of the Gut Microbiome in Cerebral Cavernous Malformation: A New Novel Therapeutic Strategy?
    Hamid Reza Sadegh, Jaesung Peter Choi · 2025 · International Journal of Molecular Sciences
  23. The Role of the Gut Microbiota in Vascular Physiology and Health
    Maria Adriana Neag, Liviu-Ștefan Moacă, Andrada Larisa Deac, Dan Claudiu Măgureanu, Damiana-Maria Vulturar, Doina Adina Todea, Diana Gherman, Anca Dana Buzoianu, Cristian Gherman, Florentina Claudia Militaru · 2025 · International Journal of Molecular Sciences
  24. Predictors of arterial hypertension in children (A Review)
    Alla V. Burlutskaya, O. G. Korobkina · 2020 · Кубанский научный медицинский вестник
  25. Antioxidant effect of gut microbiota on cardiovascular system
    Anasnasiia Ivanova, E.Yu. Rysenkova, М Д Смирнова, Т В Фофанова, Medvedev Os · 2021 · Russian Cardiology Bulletin
  26. Elevated Circulating Levels of Gut Microbe-Derived Trimethylamine N-Oxide Are Associated with Systemic Sclerosis
    Karen J. Ho, Lutfiyya N. Muhammad, Linh Ngo Khanh, Xinmin S. Li, Mary A. Carns, Kathleen Aren, Seok-Jo Kim, Priyanka Verma, Stanley L. Hazen, John Varga · 2024 · Journal of Clinical Medicine
  27. Altered colonic microflora and its metabolic profile in mice with acute viral myocarditis induced by coxsackievirus B3
    Yimin Xue, Shirong Lin, Mingguang Chen, Jun Ke, Jiuyun Zhang, Qiaolian Fan, Yimei Chen, Feng Chen · 2024 · Virology Journal
  28. The Novel Dimensions of Cardio-Metabolic Health: Gut Microbiota, Dysbiosis and its Fallouts
    N Vinod · 2019 · Significances of Bioengineering & Biosciences
  29. The Novel Dimensions of Cardio-Metabolic Health: Gut Microbiota, Dysbiosis and its Fallouts
    Vinod Nikhra · 2019 · Current Research in Diabetes & Obesity Journal
  30. Role of the Microbiome in Cardiovascular Disease
    Thanat Chaikijurajai, Jennifer D. Wilcox, W.H. Wilson Tang · 2021 · Contemporary cardiology
  31. Gut microbiome in heart failure and aortic stenosis
    Pavol Fülöp, Mariana Dvorožňáková, Marianna Vachalcová, Zuzana Fülöpová, Katarína Šoltýs, Gabriel Valočík · 2022 · Vnitřní lékařství
  32. Is Trimethylamine N-oxide (TMAO) Associated with NF-κB mRNA Expression in Patients with Coronary Artery Disease?
    Beatriz Oliveira Da Cruz, Karen Salve Coutinho‐Wolino, L. Cardozo, Aline D’Ávila Pereira, Cláudio Tinoco Mesquita, Peter Stenvinkel, Peter Bergman, Denise Mafra, Milena Barcza Stockler‐Pinto · 2024 · International Journal of Cardiovascular Sciences
  33. Role of the gut microbiota in human health
    Aleksandra Chałupnik, Zuzanna Chilimoniuk, Anna Sobstyl, Maciej Dobosz, Aleksandra Borkowska, Małgorzata Wieteska · 2020 · Journal of Education Health and Sport
  34. Trimethylamine-N-Oxide as a Novel Biomarker in Acute Decompensated Heart Failure: A Comparative Study With Stable Heart Failure Patients
    Yemlihan Ceylan, Muhammed Kaya, Murat Saygın, Hamit Hakan · 2025 · Angiology
  35. Synergistic Role of Aerobic Exercise and Vitamin C in Reducing Hypertension and Restoring Redox–Inflammatory Balance
    Sheraz Ahmad, Khalid Abdul Majeed, Saima Masood, Muhammad Shahbaz Yousaf, Muhammad Bilal Akram, Abdullah Arif Saeed, Habib Rehman · 2026 · Nutrients
  36. Intestinal Permeability Biomarkers for Predicting Cardiometabolic Risk in Type 2 Diabetes Mellitus
    Nursel Dal, Saniye Bilici, Sirin Akin, Perim Fatma Türker · 2026 · Nutrients
  37. 3,3′-diindolylmethane ameliorates non-alcoholic fatty liver disease by inhibiting the FMO3-TMAO axis in mice
    Runsheng Chen, Hua Liu, Tinfeng Yang, Zhonghao Jiang, Zeyu He, Xinpeng Zhang, Baolin Qian, Wenguang Fu · 2026 · Biochemical and Biophysical Research Communications
  38. Gut microbiota-derived metabolite trimethylamine N-oxide in major adverse cardiovascular events: Mechanisms, risk assessment, and therapeutic strategies
    Samuel Jaimez Alvarado, María Fernanda Flores Enciso, Amedeo Amedei, María Magdalena Aguirre‐García · 2026 · World Journal of Cardiology
  39. Contractile effect of trimethylamine and trimethylamine‐n‐oxide on isolated human umbilical arteries
    Mert Can Ongun, Gökçen Örgül, Çetın Çelık, Hülagu Barışkaner · 2023 · Journal of obstetrics and gynaecology research
  40. Relationship between non-alcoholic fatty liver disease and cardiovascular disease
    Zhao-Chun Chi · 2020 · World Chinese Journal of Digestology
  41. Kardiyovasküler Hastalıklarda Bağırsak Mikrobiyota Metaboliti Trimetilamin N-oksit (TMAO) : Önleme ve Tedavi İçin Yeni Bir Molekül mü?
    Reyhan Nergiz‐Unal, Buket Gönen · 2021 · Akdeniz Medical Journal
  42. Gut Microbe-Derived Metabolite Trimethylamine N-Oxide Activates PERK to Drive Mesenchymal Differentiation and Fibrosis
    Seok-Jo Kim, Swarna Bale, Qianqian Wan, Johann Eli Gudjonsson, Stanley L. Hazen, Paul W. Harms, Pei‐Suen Tsou, Dinesh Khanna, Lam C. Tsoi, Nilaksh Gupta et al. · 2021 · SSRN Electronic Journal
  43. Trimethylamine N-Oxide (TMAO) links peripheral insulin resistance and cognitive deficiencies in a senescence accelerated mouse model
    Manuel H. Janeiro, Elena Puerta, María Lanz, Fermin Ignacio Milagro, María Javier Ramírez, Maite Solas · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Ginger essential oil and citral ameliorate atherosclerosis via modulating TMAO and gut microbiota in ApoE−/− mice fed on Gubra amylin NASH diet with ʟ-carnitine
    Lee‐Yan Sheen, Suraphan Panyod, Wei‐Kai Wu, Sin-Yi Peng, Yea-Jing Tseng, Ya-Chi Hsieh, Rou-An Chen, Huai‐Syuan Huang, Yi‐Hsun Chen, Hsiao-Li Chuang et al. · 2022 · Research Square
  45. Gut Dysbiosis in Arterial Hypertension
    José Luiz de Brito Alves, Evandro Leite de Souza, Josiane C. Cruz, Camille Moura Balarini, Marciane Magnani, Hubert Vidal, Valdir A. Braga · 2019 · Elsevier eBooks
  46. Should patients with heart failure listen to their gut?
    John James Atherton, Chamindie Punyadeera · 2020 · The Medical Journal of Australia
  47. Gut microbiota, lipid metabolism and systemic inflammation in common variable immunodeficiency: A translational research approach
    Magnhild Eide Macpherson · 2020 · NORA - Norwegian Open Research Archives
  48. Implications of microbiota in the pathogenesis of diabetes mellitus and cardiovascular disease
    Daniela Maria Tănase, Alina Mihaela Leustean, Evelina Maria Gosav · 2021 · Elsevier eBooks
  49. Gut Microbial Dysbiosis and Cardiovascular Diseases
    Amin Gasmi, Sàdaf Noor, Salva Piscopo, Sophie Berthouze · 2021 · Elsevier eBooks
  50. Gut microbiota and their effects on atherosclerosis, platelet function, and hypertension
    Asim K. Duttaroy · 2021 · Elsevier eBooks
  51. References
    2018 · Elsevier eBooks
  52. Product of metabolic activity of intestinal microbium trimethylamine-N-oxide (TMAO)— biomarker of progression of atherosclerosis-copy in the heart of the heart
    К.О. Shyshkan-Shyshova, О.В. Zinych · 2022 · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)
  53. Trimethylamine N-Oxide (TMAO) as a Biomarker
    Rosita Gabbianelli, Laura Bordoni · 2022 · Biomarkers in disease
  54. Gut Microbial Metabolite Trimethylamine-N-Oxide and Its Role in Cardiovascular Diseases
    Shubham Barik, Aritra Mukherjee, Angelina Job Kolady, Boda Karunakar, Tony Grace · 2022 · IntechOpen eBooks
  55. Growth rate, haematology and serum biochemistry of broilers fed diets supplemented with choline chloride
    Patience C. Ugwu, Chinelo Nnenna Uju, Chinwe Justina Aronu, Anne MORGAN, Glory SUNDAY, Chinenye AHAMEFULA, Obinna IDIGOH, Chuka Ezema · 2022 · Notulae Scientia Biologicae
  56. Trimethylamine N-Oxide (TMAO) as a Biomarker
    Rosita Gabbianelli, Laura Bordoni · 2022 · Biomarkers in disease
  57. Kardiyovasküler hastalıklarda bağırsak mikrobiyotasının rolü
    Ebrar Kökcü, Üla Akil, Esma Asil · 2022 · Toros University Journal of Food Nutrition and Gastronomy
  58. Gut Microflora and Atherosclerotic Cardiovascular Disease: A Review
    Piyush Goel, Nidhi Garg, Pushp Lata, Raj Kumar, Kiran Bala · 2022 · Microsphere
  59. Causal Effects of Gut Microbiome on Cardiovascular diseases: A Two-Sample Mendelian Randomization Study
    Zixi Xiao, Xueyan Zang, Zhongyu Dai, Jinting Ye, Yuhua Zheng, Hanyi Yao, Ling Liu · 2023 · Research Square
  60. Gut Microbiota and Cardiovascular Disease
    Shaimaa H. Negm · 2023
  61. ผลของการบรโภคฟกขาวตอระดบไตรเมทลามนเอนออกไซดในเลอดและการเกดโรคหวใจในหนไตวายเรอรง
    ภานุมาศ เข้มแข็ง, ฐสิณัส ดิษยบุตร, ณัฐธยาน์ ช่วยเพ็ญ, สุวิมล ทรัพย์วโรบล · 2022
  62. Trimetilamīna N-oksīda regulācija kardiometabolo slimību ārstēšanā. Promocijas darba kopsavilkums
    Melita Ozola · 2023
  63. Regulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Summary of the Doctoral Thesis
    Melita Ozola · 2023
  64. Regulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Doctoral Thesis
    Melita Ozola · 2023
  65. THE ROLE OF THE INTESTINAL MICROBIOTA METABOLITE TMAO IN THE PATHOGENESIS OF VARIOUS DISEASES
    Nadezhda Samoilova-Bedych, Е.М. Laryushina, Alexandr Marchenko, А.К. Сейсенбекова · 2024 · Farmaciâ Kazahstana
  66. Atrial fibrillation in coronary artery disease patients: gut microbiota composition and echocardiography indexes
    Iryna O. Melnychuk, M.L. Sharayeva · 2023 · ScienceRise Medical Science
  67. Pathogenetic relationship of microbiome and metabolic disorders on the background of hypertension and gout: Potential targets of pharmacotherapy
    Snezhana D Sinyushkina, A. V. Gorinova, A. S. Belousova, Yu. А. Sorokina, О. В. Занозина · 2024 · Meditsinskiy sovet = Medical Council
  68. References
    2024 · Elsevier eBooks
  69. Illness Comorbidities in Relation to Inflammatory Processes
    Hymie Anisman, Shawn P. Hayley, Alexander Kusnecov · 2024 · Elsevier eBooks
  70. Trimethylamine N-Oxide Aggravates Thoracic Aortic Aneurysm by Inhibiting Axl to Promote Vascular Smooth Muscle Cell Dysfunction
    Shuai Leng, Zhiqiao Dang, Shishan Xue, Haijie Li, Baowei Shao, Yansong Ning, Leilei Zhang, Honglu Wang, Pengfei Zhang, Xilong Teng et al. · 2025 · Journal of Cardiovascular Pharmacology
  71. Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study
    Hao Huang, Sijing Cheng, Tianxin Long, Bingqi Fu, Juwei Yang, Chi Cai, Min Gu, Hongxia Niu, 陈旭华, Wei Hua et al. · 2025 · Clinical Biochemistry
  72. Unraveling the vascular fallout of TMAO in CKD: Time to look beyond GATA4?
    Muhammad Khubaib Iftikhar, Muhammad Hamza, Mirza Baig, Saad Sajjad Khan · 2025 · Journal of Cardiology
  73. Demystifying the association of the gut–TMAO–heart axis: focusing on gut microbiota in myocardial infarction
    Krushna Ch Maharana, Mayuri Adsule, M. Rajkumar, Gopal Vishwas, Sanjiv Singh · 2025 · Next research.
  74. Additional file 1 of Circulating TMAO, the gut microbiome and cardiometabolic disease risk: an exploration in key precursor disorders
    Saba Naghipour, Amanda J. Cox, Joshua J Fisher, Manuel R. Plan, Terra Stark, West, Nic, Jason N. Peart, John Patrick Headrick, Eugene F. Du Toit · 2024 · Figshare
  75. THE ROLE OF GUT MICROBIOME IN PREVENTION AND DEVELOPMENT OF ATHEROSCLEROSIS
    Agnieszka Bajkacz, Katarzyna Piotrowicz, Hubert Piotrowicz, Jacek Kurzeja, W Kraśnik, Olga Jankowska, Anna Rogala, Joanna Osmólska · 2025 · International Journal of Innovative Technologies in Social Science
  76. Répression des oxydations phosphorylantes par l'axe de signalisation NR2F2-MTERF3-GDF15 dans la peau soumise à un stress hyperglycémique
    Seyta Ley‐Ngardigal · 2024 · theses.fr (ABES)
  77. Predicting poor prognosis risk after endovascular thrombectomy for acute ischemic stroke: combination of TMAO and white matter lesions
    Chu Zhou, Qi-Yang Yuan, Yu-Kun Wang, Chongke Zhong, Y Q Liu, Fen-Fang Gao, Rong-Rong Liu, Wenhua Li, Ruo-Yu Qin, Shi-Guang Zhu et al. · 2026 · Scandinavian Journal of Clinical and Laboratory Investigation
  78. Red Meat in Human Evolution, Health, and Disease: From A Blessing to A Curse?
    Juston Jaco, Kalyan Banda, Ajit P Varki, Pascal Gagneux · 2026 · The Quarterly Review of Biology
  79. Gut Microbiota in Metabolic Syndrome: Differences in Microbial Signatures and Clinical Profiles
    Giuseppe Guido Maria Scarlata, Andrej Belančić, Emidio Scarpellini, Almir Fajkić, Tomislav Meštrović, Roberto Vicinanza, Davor Štimac, Ludovico Abenavoli · 2026 · Medicina
  80. The gut-retina axis in diabetic retinopathy: a new paradigm for pathogenesis and therapeutic intervention
    Bainan Tong, Mingxuan Wang, Xinyue Yang, Lu Liu · 2026 · Frontiers in Immunology