Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels
Open accessAbstract
-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body. The renin-angiotensin-aldosterone system is acknowledged as being vital in the body's hormone system and plays a fundamental role in the maintenance of water and electrolyte balance and blood pressure regulation. There is growing evidence that the renin-angiotensin-aldosterone system has profound influences on the expression and bioactivity of BK channels. In this review, we focus on the molecular mechanisms underlying the regulation of BK channels mediated by the renin-angiotensin-aldosterone system and its potential as a target for clinical drugs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Despite high Ang-II levels, POTS patients are paradoxically prone to hypovolemia.
“Despite their high Ang-II levels, POTS patients are paradoxically prone to hypovolemia (37).”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rab GTPases as coordinators of vesicle traffic
Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413 · see citing works
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131 · see citing works
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924 · see citing works
Human Hypertension Caused by Mutations in WNK Kinases
Wilson, F. H., Disse-Nicodème, S., Choate, K. A., Ishikawa, K., Nelson-Williams, C. J., Desitter, I., Günel, M., Milford, D. V., Lipkin, G. W., Achard, J., et al. (2001) · Science · doi:10.1126/science.1062844 · Cited by 1,466 · see citing works
Touyz, R. M., & Schiffrin, E. L. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01471-6 · Cited by 933 · see citing works
Ushio‐Fukai, M., Alexander, R. W., Akers, M., & Griendling, K. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15022 · Cited by 650 · see citing works
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Hilenski, L. L., Clempus, R. E., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000112024.13727.2c · Cited by 573 · see citing works
Ushio‐Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., & Griendling, K. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22699 · Cited by 558 · see citing works
High-conductance potassium channels of the SLO family
Salkoff, L., Butler, A., Ferreira, G., Santi, C. M., & Wei, A. D. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1992 · Cited by 538 · see citing works
Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function
Carey, R. M., Wang, Z.-Q., & Siragy, H. M. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.155 · Cited by 431 · see citing works
Meredith, A. L., Thorneloe, K. S., Werner, M. E., Nelson, M. T., & Aldrich, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405621200 · Cited by 350 · see citing works
Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation
Cohen, A. W., Razani, B., Schubert, W., Williams, T. M., Wang, X., Iyengar, P., Brasaemle, D., Scherer, P. E., & Lisanti, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1261 · Cited by 320 · see citing works
Structure of the Human BK Channel Ca 2+ -Activation Apparatus at 3.0 Å Resolution
Yuan, P., Leonetti, M. D., Pico, A. R., Hsiung, Y., & MacKinnon, R. (2010) · Science · doi:10.1126/science.1190414 · Cited by 300 · see citing works
Behrens, R., Nolting, A., Reimann, F. M., SCHWARZ, M., Waldschütz, R., & Pongs, O. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01584-2 · Cited by 285 · see citing works
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms
Verı́ssimo, F., & Jordan, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204726 · Cited by 284 · see citing works
Flow-dependent K+secretion in the cortical collecting duct is mediated by a maxi-K channel
Woda, C. B., Bragin, A., Kleyman, T. R., & Satlin, L. M. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.5.f786 · Cited by 284 · see citing works
BK channel activation: structural and functional insights
Lee, U. S., & Cui, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.06.004 · Cited by 244 · see citing works
MaxiK channel partners: physiological impact
Lü, R., Alioua, A., Kumar, Y., Eghbali, M., Stefani, E., & Toro, L. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098913 · Cited by 234 · see citing works
Sausbier, M., Arntz, C., Bucurenciu, I., Zhao, H. L., Zhou, X.-B., Sausbier, U., Feil, S. C., Kamm, S., Essin, K., Sailer, C. A., et al. (2005) · Circulation · doi:10.1161/01.cir.0000156448.74296.fe · Cited by 232 · see citing works
mitoBK Ca is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location
Singh, H., Lü, R., Bopassa, J. C., Meredith, A. L., Stefani, E., & Toro, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302028110 · Cited by 210 · see citing works
Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1
Wynne, B. M., Chiao, C.-W., & Webb, R. C. (2008) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2008.09.002 · Cited by 204 · see citing works
Arima, S., Endo, Y., Yaoita, H., Omata, K., Ogawa, S., Tsunoda, K., Abe, M., Takeuchi, K., Abe, K., & Ito, S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119829 · Cited by 171 · see citing works
Role of Charged Residues in the S1–S4 Voltage Sensor of BK Channels
Ma, Z., Lou, X. J., & Horrigan, F. T. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200509421 · Cited by 164 · see citing works
Caveolins: structure and function in signal transduction.
Krajewska, W. M., & Masłowska, I. (2004) · PubMed · Cited by 162 · see citing works
Chen, L., Tian, L., Macdonald, S. H.-F., McClafferty, H., Hammond, M. S. L., Huibant, J.-M., Ruth, P., Knaus, H., & Shipston, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505383200 · Cited by 160 · see citing works
Aldosterone Paradox: Differential Regulation of Ion Transport in Distal Nephron
Arroyo, J. P., Ronzaud, C., Lagnaz, D., Staub, O., & Gamba, G. (2011) · Physiology · doi:10.1152/physiol.00049.2010 · Cited by 146 · see citing works
Erectile dysfunction in mice lacking the large‐conductance calcium‐activated potassium (BK) channel
Werner, M. E., Zvara, P., Meredith, A. L., Aldrich, R. W., & Nelson, M. T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093823 · Cited by 139 · see citing works
Wang, X.-L., Ye, D., Peterson, T. E., Cao, S., Shah, V. H., Katušić, Z. S., Sieck, G. C., & Lee, H.-C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410987200 · Cited by 137 · see citing works
Nieves‐Cintrón, M., Amberg, G. C., Nichols, C. B., Molkentin, J. D., & Santana, L. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608822200 · Cited by 126 · see citing works
Grunnet, M., & Kaufmann, W. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402254200 · Cited by 121 · see citing works
Pharmacology of Muscarinic Receptor Subtypes Constitutively Activated by G Proteins
Burstein, E. S., Spalding, T. A., & Brann, M. R. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.2.312 · Cited by 113 · see citing works
Dietary K+regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct
Najjar, F., Zhou, H., Morimoto, T., Bruns, J. B., Li, H.-S., Liu, W., Kleyman, T. R., & Satlin, L. M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00057.2005 · Cited by 110 · see citing works
Ca 2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct
Liu, W., Morimoto, T., Woda, C. B., Kleyman, T. R., & Satlin, L. M. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00057.2007 · Cited by 105 · see citing works
Woda, C. B., Miyawaki, N., Ramalakshmi, S., Ramkumar, M., Rojas, R., Zavilowitz, B. J., Kleyman, T. R., & Satlin, L. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00191.2003 · Cited by 102 · see citing works
Cochlear Function in Mice Lacking the BK Channel α, β1, or β4 Subunits
Pyott, S. J., Meredith, A. L., Fodor, A. A., Vázquez, A. E., Yamoah, E. N., & Aldrich, R. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608726200 · Cited by 102 · see citing works
Dual role of protein kinase C on BK channel regulation
Zhou, X., Wulfsen, I., Utku, E., Sausbier, U., Sausbier, M., Wieland, T., Ruth, P., & Korth, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912029107 · Cited by 100 · see citing works
Balderas, E., Zhang, J., Stefani, E., & Toro, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00104 · Cited by 99 · see citing works
Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits
Li, Q., & Yan, J. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.015 · Cited by 94 · see citing works
Angiotensin II Relaxes Microvessels Via the AT 2 Receptor and Ca 2+ -Activated K + (BK Ca ) Channels
Dimitropoulou, C., White, R. E., Fuchs, L. C., Zhang, H., Catravas, J. D., & Carrier, G. O. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.301 · Cited by 92 · see citing works
Apical potassium channels in the rat connecting tubule
Frindt, G., & Palmer, L. G. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00169.2004 · Cited by 90 · see citing works
Dynamic regulation of β1 subunit trafficking controls vascular contractility
Leo, M. D., Bannister, J. P., Narayanan, D., Nair, A., Grubbs, J. E., Gabrick, K. S., Boop, F. A., & Jaggar, J. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317527111 · Cited by 86 · see citing works
Trafficking and stability of voltage-gated calcium channels
Simms, B., & Zamponi, G. W. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0843-y · Cited by 86 · see citing works
BK channel inactivation gates daytime excitability in the circadian clock
Whitt, J. P., Montgomery, J. R., & Meredith, A. L. (2016) · Nature Communications · doi:10.1038/ncomms10837 · Cited by 84 · see citing works
Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs
Conn, P. M., & Ulloa‐Aguirre, A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.003 · Cited by 82 · see citing works
Regulation of Renal Potassium Secretion: Molecular Mechanisms
Welling, P. A. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.04.002 · Cited by 79 · see citing works
Yoshimoto, T., Fukai, N., Sato, R., Sugiyama, T., Ozawa, N., Shichiri, M., & Hirata, Y. (2004) · Endocrinology · doi:10.1210/en.2003-1583 · Cited by 78 · see citing works
Alioua, A., Lü, R., Kumar, Y., Eghbali, M., Kundu, P., Toro, L., & Stefani, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709802200 · Cited by 73 · see citing works
Lü, T., Zhang, D., Wang, X.-L., He, T., Wang, R., Chai, Q., Katušić, Z. S., & Lee, H.-C. (2010) · Circulation Research · doi:10.1161/circresaha.109.209767 · Cited by 73 · see citing works
Self-citationProtein kinase C inhibits BKCachannel activity in pulmonary arterial smooth muscle
Barman, S. A., Zhu, S., & White, R. E. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00207.2003 · Cited by 71 · see citing works
Protein kinase C reduces the KCa current of rat tail artery smooth muscle cells
Schubert, R., Noack, T., & Serebryakov, V. N. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.3.c648 · Cited by 69 · see citing works
Goette, A., & Lendeckel, U. (2008) · EP Europace · doi:10.1093/europace/eum283 · Cited by 68 · see citing works
Effect of aldosterone on BK channel expression in mammalian cortical collecting duct
Estilo, G., Liu, W., Pastor‐Soler, N. M., Mitchell, P. P., Carattino, M. D., Kleyman, T. R., & Satlin, L. M. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00002.2008 · Cited by 67 · see citing works
PKC activates BKCachannels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase
Barman, S. A., Zhu, S., & White, R. E. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00259.2003 · Cited by 64 · see citing works
Locations of the β1 transmembrane helices in the BK potassium channel
Liu, G., Zakharov, S. I., Yang, L., Wu, R. S., Deng, S., Landry, D. W., Karlin, A., & Marx, S. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805212105 · Cited by 62 · see citing works
Caveolin-Dependent Angiotensin II Type 1 Receptor Signaling in Vascular Smooth Muscle
Ushio‐Fukai, M., & Alexander, R. W. (2006) · Hypertension · doi:10.1161/01.hyp.0000242907.70697.5d · Cited by 62 · see citing works
Ketsawatsomkron, P., Lorca, R. A., Keen, H. L., Weatherford, E. T., Liu, X., Pelham, C. J., Grobe, J. L., Faraci, F. M., England, S. K., & Sigmund, C. D. (2012) · Circulation Research · doi:10.1161/circresaha.112.271577 · Cited by 58 · see citing works
A Role for the S0 Transmembrane Segment in Voltage-dependent Gating of BK Channels
Koval, O. M., Fan, Y., & Rothberg, B. S. (2007) · The Journal of General Physiology · doi:10.1085/jgp.200609662 · Cited by 52 · see citing works
Relationship between Pore Occupancy and Gating in BK Potassium Channels
Piskorowski, R. A., & Aldrich, R. W. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200509482 · Cited by 52 · see citing works
Singh, H., Li, M., Hall, L. R. M., Chen, S., Sukur, S., Lu, R., Caputo, A., Meredith, A. L., Stefani, E., & Toro, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.058 · Cited by 49 · see citing works
Liu, W., Wei, Y., Sun, P., Wang, W., Kleyman, T. R., & Satlin, L. M. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90685.2008 · Cited by 47 · see citing works
Leo, M. D., Bulley, S., Bannister, J. P., Kuruvilla, K. P., Narayanan, D., & Jaggar, J. H. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00127.2015 · Cited by 45 · see citing works
WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism
Zhuang, J., Zhang, X., Wang, D., Li, J., Zhou, B., Shi, Z., Gu, D., Denson, D. D., Eaton, D. C., & Cai, H. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00518.2010 · Cited by 43 · see citing works
Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase
Wang, Z., Subramanya, A. R., Satlin, L. M., Pastor‐Soler, N. M., Carattino, M. D., & Kleyman, T. R. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00133.2013 · Cited by 42 · see citing works
Gorini, G., Ponomareva, O. Y., Shores, K. S., Person, M. D., Harris, R. A., & Mayfield, R. D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.12.061 · Cited by 41 · see citing works
Basset, O., Deffert, C., Foti, M., Bedard, K., Jaquet, V., Ogier‐Denis, É., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2584 · Cited by 37 · see citing works
Tricarico, D., Mele, A., & Camerino, D. C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.011 · Cited by 35 · see citing works
CFTR-dependent and -independent swelling-activated K+ currents in primary cultures of mouse nephron
Belfodil, R., Barrière, H., Rubera, I., Tauc, M., Poujeol, C., Bidet, M., & Poujeol, P. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00238.2002 · Cited by 34 · see citing works
Yue, P., Zhang, C., Lin, D., Sun, P., & Wang, W. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.004 · Cited by 33 · see citing works
Zhang, Z., Li, M., Lü, R., Alioua, A., Stefani, E., & Toro, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.595603 · Cited by 32 · see citing works
Self-citationLow Na, High K Diet and the Role of Aldosterone in BK-Mediated K Excretion
Cornelius, R. J., Wen, D., Li, H., Yuan, Y., Wang‐France, J., Warner, P., & Sansom, S. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115515 · Cited by 32 · see citing works
Sakamoto, K., Ohya, S., Muraki, K., & Imaizumi, Y. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08150sc · Cited by 32 · see citing works
Xiao, D., Zhu, R., & Zhang, L. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.9338 · Cited by 32 · see citing works
Heinen, A., Stroethoff, M., Schmidt, A., Stracke, N., Behmenburg, F., Bauer, I., Hollmann, M. W., & Huhn, R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.029 · Cited by 29 · see citing works
The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements
Yusifov, T., Javaherian, A. D., Pantazis, A., Gandhi, C. S., & Olcese, R. (2010) · The Journal of General Physiology · doi:10.1085/jgp.200910374 · Cited by 29 · see citing works
Choi, S., Kim, J. A., Kim, T. H., Li, H., Shin, K., Lee, Y., Oh, S., Pewzner‐Jung, Y., Futerman, A. H., & Suh, S. H. (2015) · Aging Cell · doi:10.1111/acel.12388 · Cited by 27 · see citing works
Hristov, K. L., Smith, A. C., Parajuli, S. P., Malysz, J., & Petkov, G. V. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00325.2013 · Cited by 26 · see citing works
Biophysics of BK Channel Gating
Pantazis, A., & Olcese, R. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.013 · Cited by 26 · see citing works
Maqoud, F., Cetrone, M., Mele, A., & Tricarico, D. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00121.2016 · Cited by 26 · see citing works
Wang, R.-X., Shi, H., Chai, Q., Wu, Y. X., Sun, W., Ji, Y., Yao, Y., Li, K. L., Zhang, C. Y., Zheng, J., et al. (2012) · PubMed · Cited by 23 · see citing works
Self-citationThompson, J. B., Wade, S. M., Harrison, J. K., Salafranca, M. N., & Neubig, R. R. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37376-8 · Cited by 22 · see citing works
Angiotensin II and the Cardiac Complications of Diabetes Mellitus
Connelly, K. A., Boyle, A., & Kelly, D. J. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781662984 · Cited by 20 · see citing works
The inhibitory effect of angiotensin II on BKCa channels in podocytes via oxidative stress
Gao, N., Wang, H., Zhang, X., & Yang, Z. R. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2221-1 · Cited by 19 · see citing works
Angiotensin II stimulates sympathetic neurotransmission to adipose tissue
King, V. L., English, V. L., Bharadwaj, K. G., & Cassis, L. A. (2013) · Physiological Reports · doi:10.1002/phy2.14 · Cited by 18 · see citing works
Lü, T., Jiang, B., Wang, X.-L., & Lee, H.-C. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0048 · Cited by 18 · see citing works
Li, S., Fang, Q., Zhou, A., Wu, L., Shi, A., Cao, L., Zhu, H., Liu, Y., Mao, C., & Xu, Z. (2012) · Hypertension Research · doi:10.1038/hr.2012.146 · Cited by 17 · see citing works
Balakumar, P., Anand‐Srivastava, M. B., & Jagadeesh, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.003 · Cited by 17 · see citing works
Albarwani, S., Al‐Siyabi, S., AL-HUSSEINI, I., Al‐Ismail, A., Al‐Lawati, I., Al-Bahrani, I. R., & Tanira, M. O. M. (2015) · Physiological Research · doi:10.33549/physiolres.932780 · Cited by 13 · see citing works
Bo, L., Jiang, L., Zhou, A., Wu, C., Li, J., Gao, Q., Zhang, P., Lv, J., Li, N., Gu, X., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400841 · Cited by 12 · see citing works
Li, T., Zhou, R., Yao, Y., Yang, Q., Zhou, C., Wu, W., Li, Q., You, Z., Zhao, X., Yang, L., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5606 · Cited by 12 · see citing works
Moslemi, F., Taheri, P., Azimipoor, M., Ramtin, S., Hashemianfar, M., Ashjerdi, A. M., Eshraghi-Jazi, F., Talebi, A., Nasri, H., & Nematbakhsh, M. (2016) · Journal of Renal Injury Prevention · doi:10.15171/jrip.2016.29 · Cited by 12 · see citing works
Aldosterone a Relevant Factor in the Beginning and Evolution of Arterial Hypertension
Ruilope, L. M., & Tamargo, J. L. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx010 · Cited by 5 · see citing works
Cheng, M. (2011) · Physiology · doi:10.1152/physiol.00026.2011 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 93 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Postural orthostatic tachycardia syndrome: mechanisms and new therapies
Mar, P. L., & Raj, S. R. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-041818-011630 · Cited by 122 · see citing works
Lü, T., Chai, Q., Jiao, G., Wang, X.-L., Sun, X., Furuseth, J. D., Stulak, J. M., Daly, R. C., Greason, K. L., Cha, Y., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy137 · Cited by 29 · see citing works
Glucose fluctuations promote vascular BK channels dysfunction via PKCα/NF-κB/MuRF1 signaling
Zhang, Z., Qian, L., Wang, N., Miao, L.-F., Ma, X., Dang, S., Wu, Y., Liu, X., Li, X., Chai, Q., et al. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.021 · Cited by 25 · see citing works
Self-citationNon-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome
Chakraborty, P., Farhat, K., Morris, L. M., Whyte, S., Yu, X., & Stavrakis, S. (2023) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2023.20 · Cited by 11 · see citing works
The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling
Zhang, X., Hai, T., Xie, C., Yang, Y., Li, P., & Cheng, J. (2024) · Channels · doi:10.1080/19336950.2024.2418128 · Cited by 9 · see citing works
Wang, M., Yin, X., Li, S., Zhang, X., Yi, M., He, C., Li, X., Wang, W., Zhang, S., & Liu, H. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024046 · Cited by 8 · see citing works
Regulation of ion channels in the microcirculation by mineralocorticoid receptor activation
Chambers, L. C., & Dorrance, A. M. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.02.001 · Cited by 8 · see citing works
Wen, J., Li, P., Cheng, J., Wang, N., Mao, L., Tan, X., Zeng, X., Xia, D., Zhou, Y., Yang, Q., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.04.013 · Cited by 6 · see citing works
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac132.198 · Cited by 2 · see citing works
Li, X.-Y., Qian, L.-L., Wu, Y., Zhang, Y.-M., Dang, S., Liu, X.-Y., Tang, X., Lu, C.-Y., & Wang, R.-X. (2023) · Diabetes & vascular disease research · doi:10.1177/14791641231197107 · Cited by 2 · see citing works
Self-citationLi, Y., Sun, Y., Yue, M., Gao, M., Wang, L., Wu, Y., Yin, X., Zhang, S., & Liu, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.17.464722
Lytvynenko, V. V., & Sid, E. (2025) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.25.2.55
- Authors
- Zhang, Z.-Y., Qian, L.-L., & Wang, R.-X.
- Affiliations
- Wuxi People's Hospital (CN)
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2017-09-13
- Volume
- 8
- Pages
- 698-698
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC5601423
- OpenAlex
- W2754580693
- Cited by
- 12
- References
- 93
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81370303, 81500249)
- Natural Science Foundation of Jiangsu Province (BK20151110)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- renin-angiotensin-aldosterone system, BK channels, voltage-gated potassium channels, angiotensin II, aldosterone, blood pressure regulation, electrolyte balance, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
