Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity
Open accessAbstract
Successful embryo implantation requires receptive endometrium, which is conducive to the process of embryo recognition, adhesion and invasion within a certain period of time and is inseparable from the dynamic interaction between 17β-estradiol (E2) and progesterone (P4). Proper glucose metabolism is critical for the profound physiological changes in the endometrium entering the receptive state. And glucose transporters (GLUTs) are responsible for intracellular uptake of glucose and are the first step in glucose metabolism. Prior literature has reported the presence of GLUTs in the endometrium. However, we still do not understand the specific mechanisms of this process. In this study, we identified the effect of P4 on glucose transporter 1 (GLUT1) using in vivo animal models and determined the regulation of glucose metabolism by P4 in cells. We highly suspect that this pregnancy failure may be due to reduced GLUT1-mediated glucose metabolism, resulting in a decrease in endometrial receptivity caused by an inadequate energy supply and synthesis of substrate. Here we propose a possible mechanism to explain how embryo implantation is affected by P4 and glucose utilization under abnormal endometrial conditions.
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Progesterone affects glucose metabolism through upregulation of GLUT1 expression to increase endometrial glycolytic metabolism, attenuating skeletal and hepatic glycolytic pathways.
“affects glucose metabolism through the upregulation of GLUT1 expression to increase endometrial glycolytic metabolism, attenuating skeletal and hepatic glycolytic pathways [82–85]”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [83]
The Results sections “Endometrial GLUT1 Expression Is Induced by Progesterone” and “Progesterone Affects Glucose Metabolism and Cell Function” report increased GLUT1 expression and glycolysis after progesterone treatment. The paper does not report attenuation of skeletal or hepatic glycolytic pathways, so that part of the claim is unsupported by this source. Page numbers are unavailable in our copy. (LLM, conf=0.90)
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Self-citation
- Authors
- Zhang, H., Qi, J., Wang, Y., Sun, J., Li, Z., Sui, L., Fan, J., Liu, C., Shang, Y., Kong, L., & Kong, Y.
- Affiliations
- Dalian Medical University (CN)
- Xijing Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Corresponding author
- Shang, Yuhong
- Kong, Li
- Kong, Ying
- ORCID
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-09-24
- Volume
- 11
- Pages
- 543148-543148
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7546771
- OpenAlex
- W3088554436
- Cited by
- 38
- References
- 42
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 2 · 2021: 6
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Key Research and Development Program of Liaoning Province (2019JH2)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- progesterone, glucose transporter 1, GLUT1, glucose metabolism, endometrial receptivity, embryo implantation, estradiol, miscarriage, endometrium, glucose uptake
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