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Cited by 6Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma Management and DiagnosisTrauma and Emergency Care Studies

Recent Developments in Mouse Trauma Research Models: A Mini-Review

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Gihring, Adrian, Gärtner, Fabian, Schirmer, Melanie, Wabitsch, Martin, Knippschild, Uwe·2022·Frontiers in Physiology
DOI 10.3389/fphys.2022.866617PMC PMC9101050
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Abstract

The urgency to investigate trauma in a controlled and reproducible environment rises since multiple trauma still account for the most deaths for people under the age of 45. The most common multiple trauma include head as well as blunt thorax trauma along with fractures. However, these trauma remain difficult to treat, partially because the molecular mechanisms that trigger the immediate immune response are not fully elucidated. To illuminate these mechanisms, investigators have used animal models, primarily mice as research subjects. This mini review aims to 1) emphasize the importance of the development of clinically relevant murine trauma research, 2) highlight and discuss the existing conflict between simulating clinically relevant situations and elucidating molecular mechanisms, 3) describe the advantages and disadvantages of established mouse trauma models developed to simulate clinically relevant situations, 4) summarize and list established mouse models in the field of trauma research developed to simulate clinically relevant situations.

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  1. Anandasivam N. S. Russo G. S. B. A. Samuel A. M. Ondeck N. T. Chung S. H. (2017). Tibial Shaft Fracture: A Large-Scale Study Defining the Injured Population and Associated Injuries. J. Clin. Orthopaedics Trauma 8 (3), 225– 231. 10.1016/j.jcot.2017.07.012 PMC5605888 28951639 · DOI
  2. Avila J. J. Kim S. K. Massett M. P. (2017). Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains. Front. Physiol. 8, 974. 10.3389/fphys.2017.00974 29249981 PMC5714923 · DOI
  3. Bakowitz M. Bruns B. McCunn M. (2012). Acute Lung Injury and the Acute Respiratory Distress Syndrome in the Injured Patient. Scand. J. Trauma Resusc. Emerg. Med. 20, 54. 10.1186/1757-7241-20-54 22883052 PMC3518173 · DOI
  4. Bardenheuer M. Obertacke U. Obertacke U. Waydhas C. Nast-Kolb D. (2000). Epidemiologie des Schwerverletzten Eine prospektive Erfassung der präklinischen und klinischen Versorgung. Unfallchirurg 103 (5), 355– 363. 10.1007/s001130050550 10883594 · DOI
  5. Bernick C. Banks S. J. Shin W. Obuchowski N. Butler S. Noback M. (2015). Repeated Head Trauma Is Associated with Smaller Thalamic Volumes and Slower Processing Speed: The Professional Fighters' Brain Health Study. Br. J. Sports Med. 49 (15), 1007– 1011. 10.1136/bjsports-2014-093877 25633832 PMC4518758 · DOI
  6. Bhoi S. Kumar M. Mohanty S. Kamal V. Rao D. Mishra P. (2016). Bone Marrow Hematopoietic Stem Cells Behavior with or without Growth Factors in Trauma Hemorrhagic Shock. Int. J. Crit. Illn Inj. Sci. 6 (3), 119– 126. 10.4103/2229-5151.190654 27722113 PMC5051054 · DOI
  7. Bollerslev J. Klibanski A. Tritos N. (2013). Traumatic Brain Injury: Effects on the Endocrine System. J. Clin. Endocrinol. Metab. 98 (3), 27A– 28A. 10.1210/jcem.98.3.zeg27a 23472238 · DOI
  8. Bouglé A. Harrois A. Duranteau J. (2013). Resuscitative Strategies in Traumatic Hemorrhagic Shock. Ann. Intensive Care 3 (1), 1. 10.1186/2110-5820-3-1 23311726 PMC3626904 · DOI
  9. Busch R. A. Jonker M. A. Pierre J. F. Heneghan A. F. Kudsk K. A. (2016). Innate Mucosal Immune System Response of BALB/c vs C57BL/6 Mice to Injury in the Setting of Enteral and Parenteral Feeding. JPEN J. Parenter. Enteral Nutr. 40 (2), 256– 263. 10.1177/0148607114558489 25403938 PMC4433866 · DOI
  10. Chen K. Gu H. Zhu L. Feng D.-F. (2019). A New Model of Repetitive Traumatic Brain Injury in Mice. Front. Neurosci. 13, 1417. 10.3389/fnins.2019.01417 32038131 PMC6985558 · DOI
  11. Cheriyan T. Ryan D. J. Weinreb J. H. Cheriyan J. Paul J. C. Lafage V. (2014). Spinal Cord Injury Models: A Review. Spinal Cord 52 (8), 588– 595. 10.1038/sc.2014.91 24912546 · DOI
  12. Chrysou K. Halat G. Hoksch B. Schmid R. A. Kocher G. J. (2017). Lessons from a Large Trauma Center: Impact of Blunt Chest Trauma in Polytrauma Patients-Still a Relevant Problem? Scand. J. Trauma Resusc. Emerg. Med. 25 (1), 42. 10.1186/s13049-017-0384-y 28427480 PMC5399315 · DOI
  13. Clark A. L. Merritt V. C. BiglerBangen E. D. Bangen K. J. Sorg S. F. Bondi M. W. (2018). Blast-Exposed Veterans with Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning. Front. Neurol. 9, 873. 10.3389/fneur.2018.00873 30473678 PMC6237912 · DOI
  14. Corradi F. Brusasco C. Vezzani A. Palermo S. Altomonte F. Moscatelli P. (2011). Hemorrhagic Shock in Polytrauma Patients: Early Detection with Renal Doppler Resistive Index Measurements. Radiology 260 (1), 112– 118. 10.1148/radiol.11102338 21474707 · DOI
  15. Cuschieri J. Johnson J. L. Sperry J. West M. A. Moore E. Bankey J. P. P. E. (2012). Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures. Ann. Surg. 255 (5), 993– 999. 10.1097/SLA.0b013e31824f1ebc 22470077 PMC3327791 · DOI
  16. Debler L. Palmer A. Braumüller S. Kloh B. Mollnes T. E. Holzmann K. (2021). Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury. Mediators Inflamm. 2021, 1– 9. 10.1155/2021/6654318 PMC7857921 33574730 · DOI
  17. Denk S. Weckbach S. Eisele P. Braun C. K. Wiegner R. Ohmann J. J. (2018). Role of Hemorrhagic Shock in Experimental Polytrauma. Shock (Augusta, Ga.) 49 (2), 154– 163. 10.1097/SHK.0000000000000925 28614141 · DOI
  18. Denk S. Wiegner R. Hönes F. M. Messerer D. A. C. Radermacher P. Weiss M. (2015). Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation After Experimental and Clinical Polytrauma. Mediators Inflamm. 2015, 1– 7. 10.1155/2015/463950 PMC4628652 26556956 · DOI
  19. Efron P. A. Mohr A. M. Moore F. A. Moldawer L. L. (2015). The Future of Murine Sepsis and Trauma Research Models. J. Leukoc. Biol. 98 (6), 945– 952. 10.1189/jlb.5MR0315-127R 26034205 PMC4661039 · DOI
  20. Flurkey K. Mcurrer J. Harrison D. (2007). Mouse Models in Aging Research. Mouse Biomed. Res. III, 637– 672. 10.1016/b978-012369454-6/50074-1 · DOI
  21. Gihring A. Gärtner F. Liu C. Hoenicka M. Wabitsch M. Knippschild U. (2020). Influence of Obesity on the Organization of the Extracellular Matrix and Satellite Cell Functions after Combined Muscle and Thorax Trauma in C57BL/6J Mice. Front. Physiol. 11, 849. 10.3389/fphys.2020.00849 32848828 PMC7399228 · DOI
  22. Hardy D. Besnard A. Latil M. Jouvion G. Briand D. Thépenier C. (2016). Comparative Study of Injury Models for Studying Muscle Regeneration in Mice. PloS One 11 (1), e0147198. 10.1371/journal.pone.0147198 26807982 PMC4726569 · DOI
  23. Hayakawa M. Gando S. Ono Y. Wada T. Yanagida Y. Sawamura A. (2015). Noble-Collip Drum Trauma Induces Disseminated Intravascular Coagulation but Not Acute Coagulopathy of Trauma-Shock. Shock (Augusta, Ga.) 43 (3), 261– 267. 10.1097/SHK.0000000000000281 25423126 · DOI
  24. Hayakawa M. (2017). Pathophysiology of Trauma-Induced Coagulopathy: Disseminated Intravascular Coagulation with the Fibrinolytic Phenotype. J. Intensive Care 5, 14. 10.1186/s40560-016-0200-1 28289544 PMC5282695 · DOI
  25. Huber-Lang M. Lambris J. D. Ward P. A. (2018). Innate Immune Responses to Trauma. Nat. Immunol. 19 (4), 327– 341. 10.1038/s41590-018-0064-8 29507356 PMC6027646 · DOI
  26. Jackson S. J. Andrews N. Ball D. Bellantuono I. Gray J. Hachoumi L. (2017). Does Age Matter? The Impact of Rodent Age on Study Outcomes. Lab. Anim. 51 (2), 160– 169. 10.1177/0023677216653984 27307423 PMC5367550 · DOI · Paper page
  27. Jha R. M. Kochanek P. M. Simard J. M. (2019). Pathophysiology and Treatment of Cerebral Edema in Traumatic Brain Injury. Neuropharmacology 145 (Pt B), 230– 246. 10.1016/j.neuropharm.2018.08.004 30086289 PMC6309515 · DOI
  28. Jilka R. L. (2013). The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans. Journals Gerontol. Ser. A: Biol. Sci. Med. Sci. 68 (10), 1209– 1217. 10.1093/gerona/glt046 PMC3779631 23689830 · DOI
  29. Kung H. C. Hoyert D. L. Xu J. Murphy S. L. (2008). Deaths: Final Data for 2005. Natl. Vital Stat. Rep. 56 (10), 1. 18512336
  30. Lai W.-H. Rau C.-S. Wu S.-C. Chen Y.-C. Kuo P.-J. Hsu S.-Y. (2016). Post-traumatic Acute Kidney Injury: A Cross-Sectional Study of Trauma Patients. Scand. J. Trauma Resusc. Emerg. Med. 24 (1), 136. 10.1186/s13049-016-0330-4 27876077 PMC5120453 · DOI
  31. Lee M. A. YataniSambol A. Sambol J. T. Deitch E. A. (2008). Role of Gut-Lymph Factors in the Induction of Burn-Induced and Trauma-Shock-Induced Acute Heart Failure. Int. J. Clin. Exp. Med. 1 (2), 171. 19079671 PMC2596321
  32. Levy G. Fishman J. E. Xu D.-z. Dong W. Palange D. Vida G. (2012). Vagal Nerve Stimulation Modulates Gut Injury and Lung Permeability in Trauma-Hemorrhagic Shock. J. Trauma Acute Care Surg. 73 (2), 338– 342. 10.1097/TA.0b013e31825debd3 22846937 PMC3683843 · DOI
  33. Levy G. Fishman J. E. Xu D. Chandler B. T. J. Feketova E. Dong W. (2013). Parasympathetic Stimulation via the Vagus Nerve Prevents Systemic Organ Dysfunction by Abrogating Gut Injury and Lymph Toxicity in Trauma and Hemorrhagic Shock. Shock (Augusta, Ga.) 39 (1), 39– 44. 10.1097/SHK.0b013e31827b450d PMC3547655 23247120 · DOI
  34. Li X. Cao T. Ma S. Jing Z. Bi Y. Zhou J. (2017). Curcumin Ameliorates Cardiac Dysfunction Induced by Mechanical Trauma. Eur. J. Pharmacol. 814, 73– 80. 10.1016/j.ejphar.2017.07.048 28802718 · DOI
  35. Li Z. Li J. Zhang S. Chen G. Chi S. Li X. (2019). Metabolomics Analysis of Gut Barrier Dysfunction in a Trauma-Hemorrhagic Shock Rat Model. Biosci. Rep. 39 (1). 10.1042/BSR20181215 PMC6328858 30393232 · DOI
  36. Liang T. Ma Y.-F. Zhu J. Wang D.-X. Liu Y. (2016). A Clinical Study of Multiple Trauma Combined with Acute Lung Injury. J. Acute Dis. 5 (6), 450– 453. 10.1016/j.joad.2016.07.001 · DOI
  37. Maitz A. Haussner F. Braumüller S. Hoffmann A. Lupu L. Wachter U. (2021). Temporal-Spatial Organ Response After Blast‐Induced Experimental Blunt Abdominal Trauma. FASEB J. 35 (12), e22038. 10.1096/fj.202100995R 34748229 · DOI
  38. Makris K. Spanou L. (2016). Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes. Clin. Biochem. Rev. 37 (2), 85. 28303073 PMC5198510
  39. Marshall J. C. (2001). Surgical Treatment: Evidence-Based and Problem-Oriented. Munich. 21028753
  40. Matsutani T. Ananthasamy T. Kang S. Bland K. Chaudry I. (2005). Mouse Genetic Background Influences Severity of Immune Responses Following Trauma-Hemorrhage. Cytokine 30 (4), 168– 176. 10.1016/j.cyto.2004.12.019 15863390 · DOI
  41. Mira J. C. Nacionales D. C. Loftus T. J. Ungaro R. Mathias B. Mohr A. M. (2018). Mouse Injury Model of Polytrauma and Shock. Methods Mol. Biol. (Clifton, N.J.), 1– 15. 10.1007/978-1-4939-7526-6_1 PMC6296232 29468579 · DOI
  42. Moore E. E. Moore H. B. Lucy. Z. Hoffman M. Mutch N. J. Schöchl H. Hunt B. J. (2021). Trauma-Induced Coagulopathy. Nat. Rev. Dis. Primers 7 (1), 30. 10.1038/s41572-021-00264-3 33927200 PMC9107773 · DOI
  43. Morishita K. Coimbra R. Langness S. Eliceiri B. P. Costantini T. W. (2015). Neuroenteric Axis Modulates the Balance of Regulatory T Cells and T-Helper 17 Cells in the Mesenteric Lymph Node Following Trauma/Hemorrhagic Shock. Am. J. Physiology-Gastrointestinal Liver Physiol. 309 (3), G202– G208. 10.1152/ajpgi.00097.2015 26045612 · DOI
  44. Moulton G. A. Esmond W. G. Michaelis M. (1962). Effect of Hyperbaric Oxygenation on Noble Collip Drum Shock in the Rat, 47. Baltimore, Md: Bulletin of the School of Medicine, 42. 14476647
  45. Nikolich-Žugich J. (2014). Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories. J. Immunol. 193, 2622– 2629. 10.4049/jimmunol.1401174 6 25193936 PMC4157314 · DOI · Paper page
  46. Noble R. L. Collip J. B. (1942). A Quantitative Method for the Production of Experimental Traumatic Shock without Haemorrhage in Unanaesthetized Animals. Exp. Physiol. 31 (3), 187– 199. 10.1113/expphysiol.1942.sp000856 · DOI
  47. Norton R. Kobusingye O. (2013). Injuries. N. Engl. J. Med. 368 (18), 1723– 1730. 10.1056/NEJMra1109343 23635052 · DOI
  48. Novotny A. R. Reim D. Assfalg V. Altmayr F. Friess H. M. Emmanuel K. (2012). Mixed Antagonist Response and Sepsis Severity-Dependent Dysbalance of Pro- and Anti-Inflammatory Responses at the Onset of Postoperative Sepsis. Immunobiology 217 (6), 616– 621. 10.1016/j.imbio.2011.10.019 22204813 · DOI
  49. Ntundu S. H. Herman A. M. Kishe A. Babu H. Jahanpour O. F. Msuya D. (2019). Patterns and Outcomes of Patients with Abdominal Trauma on Operative Management from Northern Tanzania: A Prospective Single Centre Observational Study. BMC Surg. 19 (1), 69. 10.1186/s12893-019-0530-8 31242883 PMC6595599 · DOI
  50. Orlando F. Paolini C. Agarbati S. Tonnini C. Grieco A. Capelli C. (2019). Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin. JoVE 146, 58922. 10.3791/58922 31107440 · DOI
  51. Osuchowski M. F. Remick D. G. Lederer J. A. Aasen A. O. Azevedo M. L. C. Bahrami S. (2014). Abandon the Mouse Research Ship? Not Just Yet! Shock (Augusta, Ga.) 41 (6), 463– 475. 10.1097/SHK.0000000000000153 PMC4139038 24569509 · DOI
  52. Osuchowski M. F. Welch K. Siddiqui J. Remick D. G. (2006). Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality. J. Immunol. 177, 1967– 1974. 10.4049/jimmunol.177.3.1967 16849510 · DOI
  53. Pantalone D. Bergamini C. Martellucci J. Alemanno G. Bruscino A. Maltinti G. (2021). The Role of DAMPS in Burns and Hemorrhagic Shock Immune Response: Pathophysiology and Clinical Issues. Review. Ijms 22 (13), 7020. 10.3390/ijms22137020 34209943 PMC8268351 · DOI
  54. Peng N. Su L. (2017). Progresses in Understanding Trauma-Induced Coagulopathy and the Underlying Mechanism. Chin. J. Traumatol. 20 (3), 133– 136. 10.1016/j.cjtee.2017.03.002 28554592 PMC5473738 · DOI
  55. Petr M. A. Alfaras I. Krawcyzk M. Bair W.-N. MitchellMorrell S. J. Studenski C. H. S. A. (2021). A Cross-Sectional Study of Functional and Metabolic Changes during Aging Through the Lifespan in Male Mice. eLife 10. 10.7554/eLife.62952 PMC8099423 33876723 · DOI
  56. Phelos H. M. Kass N. M. Deeb A.-P. Brown J. B. (2022). Social Determinants of Health and Patient-Level Mortality Prediction After Trauma. J. Trauma Acute Care Surg. 92 (2), 287– 295. 10.1097/TA.0000000000003454 34739000 PMC8792275 · DOI
  57. Rachfalska N. Putowski Z. Krzych Ł. (2020). Distant Organ Damage in Acute Brain Injury. Brain Sci. 10 (12), 1019. 10.3390/brainsci10121019 PMC7767338 33371363 · DOI
  58. Ratliff W. A. Mervis R. F. Citron B. A. Schwartz B. Rubovitch V. Schreiber S. (2020). Effect of Mild Blast-Induced TBI on Dendritic Architecture of the Cortex and Hippocampus in the Mouse. Sci. Rep. 10 (1), 2206. 10.1038/s41598-020-59252-4 32042033 PMC7010659 · DOI
  59. Relja B. Yang B. Bundkirchen K. Xu B. Köhler K. Neunaber C. (2020). Different Experimental Multiple Trauma Models Induce Comparable Inflammation and Organ Injury. Sci. Rep. 10 (1), 20185. 10.1038/s41598-020-76499-z 33214576 PMC7678855 · DOI
  60. Seok J. Warren H. S. Cuenca A. G. Mindrinos M. N. Baker H. V. Xu W. (2013). Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases. Proc. Natl. Acad. Sci. U S A. 110 (9), 3507– 3512. 10.1073/pnas.1222878110 23401516 PMC3587220 · DOI · Paper page
  61. Spenlingwimmer T. Zipperle J. Jafarmadar M. Osuchowski M. F. Drechsler S. (2019). Comparison of Post-Traumatic Changes in Circulating and Bone Marrow Leukocytes Between BALB/c and CD-1 Mouse Strains. PloS One 14 (9), e0222594. 10.1371/journal.pone.0222594 31527918 PMC6748677 · DOI
  62. Stortz J. A. Raymond S. L. MiraMohr J. C. Moldawer L. L. Mohr A. M. Efron P. A. (2017). Murine Models of Sepsis and Trauma: Can We Bridge the Gap? ILAR J. 58 (1), 90– 105. 10.1093/ilar/ilx007 28444204 PMC5886315 · DOI
  63. Takao K. Miyakawa T. (2015). Genomic Responses in Mouse Models Greatly Mimic Human Inflammatory Diseases. Proc. Natl. Acad. Sci. U.S.A. 112 (4), 1167– 1172. 10.1073/pnas.1401965111 25092317 PMC4313832 · DOI
  64. Tawfik V. L. Quarta M. Paine P. Forman T. E. Pajarinen J. Takemura Y. (2020). Angiotensin Receptor Blockade Mimics the Effect of Exercise on Recovery After Orthopaedic Trauma by Decreasing Pain and Improving Muscle Regeneration. J. Physiol. 598 (2), 317– 329. 10.1113/JP278991 31784993 PMC8830491 · DOI
  65. Tiesi G. Reino D. Mason L. Palange D. Tomaio J. N. Deitch E. A. (2013). Early Trauma-Hemorrhage-Induced Splenic and Thymic Apoptosis Is Gut-Mediated and Toll-Like Receptor 4-Dependent. Shock (Augusta, Ga.) 39 (6), 507– 513. 10.1097/SHK.0b013e318293d020 PMC3717364 23542401 · DOI
  66. Tsukamoto T. Pape H. C. (2009). Animal Models for Trauma Research. Shock (Augusta, Ga.) 31 (1), 3– 10. 10.1097/SHK.0b013e31817fdabf 18636048 · DOI
  67. Tuttle A. H. PhilipPhilip V. M. Chesler E. J. Mogil J. S. (2018). Comparing Phenotypic Variation Between Inbred and Outbred Mice. Nat. Methods 15 (12), 994– 996. 10.1038/s41592-018-0224-7 30504873 PMC6518396 · DOI · Paper page
  68. Vella M. A. Crandall M. L. Patel M. B. (2017). Acute Management of Traumatic Brain Injury. Surg. Clin. North America 97 (5), 1015– 1030. 10.1016/j.suc.2017.06.003 PMC5747306 28958355 · DOI
  69. Villeneuve A. Joyal J.-S. Proulx F. Ducruet T. Poitras N. Lacroix J. (2016). Multiple Organ Dysfunction Syndrome in Critically Ill Children: Clinical Value of Two Lists of Diagnostic Criteria. Ann. Intensive Care 6 (1), 40. 10.1186/s13613-016-0144-6 27130424 PMC4851677 · DOI
  70. Wall J. Naganathar S. Praditsuktavorn B. Bugg O. F. McArthur S. Thiemermann C. (2019). Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity. Front. Immunol. 10, 2774. 10.3389/fimmu.2019.02774 31866998 PMC6908477 · DOI
  71. Watanabe H. Numata K. Ito T. Takagi K. Matsukawa A. (2004). Innate Immune Response in Th1- and Th2-Dominant Mouse Strains. Shock 22 (5), 460– 466. 10.1097/01.shk.0000142249.08135.e9 15489639 · DOI
  72. Weber B. Lackner I. Baur M. Gebhard F. Pfeifer R. Cinelli P. (2021a). Early Myocardial Damage (EMD) and Valvular Insufficiency Result in Impaired Cardiac Function After Multiple Trauma in Pigs. Sci. Rep. 11 (1), 1151. 10.1038/s41598-020-80409-8 33441945 PMC7806767 · DOI
  73. Weber B. Lackner I. Gebhard F. Miclau T. Kalbitz M. (2021b). Trauma, a Matter of the Heart-Molecular Mechanism of Post-Traumatic Cardiac Dysfunction. Int. J. Mol. Sci. 22 (2), 737. 10.3390/ijms22020737 PMC7828409 33450984 · DOI
  74. Weber C. D. Lefering R. Dienstknecht T. Kobbe P. Sellei R. M. Hildebrand F. (2016). Classification of Soft-Tissue Injuries in Open Femur Fractures. J. Trauma Acute Care Surg. 81 (5), 824– 833. 10.1097/TA.0000000000001216 27533903 · DOI
  75. Xiao W. Mindrinos M. N. Seok J. Cuschieri J. Cuenca A. G. Gao H. (2011). A Genomic Storm in Critically Injured Humans. J. Exp. Med. 208 (13), 2581– 2590. 10.1084/jem.20111354 22110166 PMC3244029 · DOI
  76. Yue F. Cheng Y. Breschi A. Vierstra J. Wu W. Ryba T. (2014). A Comparative Encyclopedia of DNA Elements in the Mouse Genome. Nature 515 (7527), 355– 364. 10.1038/nature13992 25409824 PMC4266106 · DOI · Paper page

Cited by

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Authors
Gihring, A., Gärtner, F., Schirmer, M., Wabitsch, M., & Knippschild, U.
Affiliations
University Hospital Ulm (DE)
Corresponding author
Knippschild, Uwe
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2022-04-29
Volume
13
Pages
866617-866617
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2022.866617
PMC
PMC9101050
OpenAlex
W4225155976
Cited by
6
References
1
Citations by year
2026: 2 · 2025: 3 · 2023: 1
FWCI
0.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Health Sciences › Medicine › Surgery › Trauma Management and Diagnosis
  • Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords
polytrauma, blunt chest trauma, head trauma, fracture, immune response

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