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The Pepper Late Embryogenesis Abundant Protein, CaDIL1, Positively Regulates Drought Tolerance and ABA Signaling
Open accessAbstract
Plants as sessile organisms constantly respond to environmental stress during their growth and development. The regulation of transpiration via stomata plays crucial roles in plant adaptation to drought stress. Many enzyme-encoding genes are involved in regulation of transpiration via modulating stomatal opening and closure. Here, we demonstrate that Capsicum annuum Drought Induced Late embryogenesis abundant protein 1 (CaDIL1) gene is a critical regulator of transpirational water loss in pepper. The expression of CaDIL1 in pepper leaves was upregulated after exposure to abscisic acid (ABA) and drought. Phenotype analysis showed that CaDIL1-silenced pepper and CaDIL1-overexpressing (OX) Arabidopsis transgenic plants exhibited reduced and enhanced drought tolerance, respectively, accompanied by an altered water loss. Furthermore, ABA sensitivity was significantly lower in CaDIL1-silenced pepper, but higher in CaDIL1-OX plants, than that in control plants, which resulted in opposite responses to drought stress in these two plant types. Collectively, our data suggest that CaDIL1 positively regulates the ABA signaling and drought stress tolerance.
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“Targeted modification of the ERECTA gene in A. thaliana has also enhanced drought tolerance by optimizing root architecture and transpiration efficiency (Wen W. et al., 2019; Lim et al., 2018).”
From Emerging applications of gene editing technologies for the development of climate-resilient crops (2025) · cites this paper as Lim et al., 2018
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Cites
1 retracted
Sengupta, S., & Majumder, A. L. (2009) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2009.02054.x · Cited by 94
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
S ALT AND D ROUGHT S TRESS S IGNAL T RANSDUCTION IN P LANTS
Zhu, J. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.091401.143329 · Cited by 5,808
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Gene networks involved in drought stress response and tolerance
Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2006) · Journal of Experimental Botany · doi:10.1093/jxb/erl164 · Cited by 2,641
Drought, salt, and temperature stress-induced metabolic rearrangements and regulatory networks
Krasensky-Wrzaczek, J., & Jonak, C. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err460 · Cited by 2,295
G UARD C ELL S IGNAL T RANSDUCTION
Schroeder, J. I., Allen, G. J., Hugouvieux, V., Kwak, J. M., & Waner, D. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.627 · Cited by 1,154
ABA-mediated transcriptional regulation in response to osmotic stress in plants
Fujita, Y., Fujita, M., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2011) · Journal of Plant Research · doi:10.1007/s10265-011-0412-3 · Cited by 1,050
Role of ABA in integrating plant responses to drought and salt stresses
Zhang, J., Jia, W., Yang, J., & Ismail, A. M. (2005) · Field Crops Research · doi:10.1016/j.fcr.2005.08.018 · Cited by 1,034
Geiger, D., Scherzer, S. H., Mumm, P., Stange, A., Marten, I., Bauer, H., Ache, P., Matschi, S., Liese, A., Al‐Rasheid, K. A. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912021106 · Cited by 924
The Enigmatic LEA Proteins and Other Hydrophilins
Battaglia, M. E., Olvera-Carrillo, Y., Garcíarrubio, A., Campos, F., & Covarrubias, A. A. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.120725 · Cited by 895
Common amino acid sequence domains among the LEA proteins of higher plants
Dure, L. S., Crouch, M. L., Harada, J. J., Ho, T. D., Mundy, J., Quatrano, R. S., Thomas, T. L., & Sung, Z. R. (1989) · Plant Molecular Biology · doi:10.1007/bf00036962 · Cited by 802
ABA signal transduction at the crossroad of biotic and abiotic stress responses
Lee, S. C., & Luan, S. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2011.02426.x · Cited by 707
Self-citationOST1 Kinase Modulates Freezing Tolerance by Enhancing ICE1 Stability in Arabidopsis
Ding, Y., Li, H., Zhang, X., Xie, Q., Gong, Z., & Yang, S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.12.023 · Cited by 675
Hubbard, K., Nishimura, N., Hitomi, K., Getzoff, E. D., & Schroeder, J. I. (2010) · Genes & Development · doi:10.1101/gad.1953910 · Cited by 675
Function of ABA in Stomatal Defense against Biotic and Drought Stresses
Lim, C. W., Baek, W., Jung, J., Kim, J.-H., & Lee, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715251 · Cited by 647
Self-citationLee, S. C., Lan, W., Buchanan, B. B., & Luan, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910601106 · Cited by 628
Self-citationCharacterization of the ABA‐regulated global responses to dehydration in Arabidopsis by metabolomics
Urano, K., Maruyama, K., Ogata, Y., Morishita, Y., Takeda, M., Sakurai, N., Suzuki, H., Saito, K., Shibata, D., Kobayashi, M., et al. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03748.x · Cited by 593
González‐Guzmán, M., Pizzio, G. A., Antoni, R., Vera‐Sirera, F., Merilo, E., Bassel, G. W., Fernández, M. A., Holdsworth, M. J., Perez-Amador, M. A., Kollist, H., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.098574 · Cited by 582
Vlad, F., Rubio, S., Rodrigues, A., Sirichandra, C., Belin, C., Robert, N., Leung, J., Rodrı́guez, P. L., Laurière, C., & Merlot, S. (2009) · The Plant Cell · doi:10.1105/tpc.109.069179 · Cited by 551
Over-expression of a LEA gene in rice improves drought resistance under the field conditions
Xiao, B., Huang, Y., Tang, N., & Xiong, L. (2007) · Theoretical and Applied Genetics · doi:10.1007/s00122-007-0538-9 · Cited by 543
Sequence and characterization of 6 Lea proteins and their genes from cotton
Baker, J. C., dennSteele, C. V., & Dure, L. S. (1988) · Plant Molecular Biology · doi:10.1007/bf00027385 · Cited by 512
Goda, H., Sasaki, E., Akiyama, K., Maruyama, A., Nakabayashi, K., Li, W., Ogawa, M., Yamauchi, Y., Preston, J., Aoki, K., et al. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03510.x · Cited by 509
Jakab, G., Ton, J., Flors, V., Zimmerli, L., Métraux, J., & Mauch‐Mani, B. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.065698 · Cited by 445
Umezawa, T., Sugiyama, N., Takahashi, F., Anderson, J. C., Ishihama, Y., Peck, S. C., & Shinozaki, K. (2013) · Science Signaling · doi:10.1126/scisignal.2003509 · Cited by 434
Zou, J., Li, X., Ratnasekera, D., Wang, C., Liu, W., Song, L.-F., Zhang, W., & Wu, W. (2015) · The Plant Cell · doi:10.1105/tpc.15.00144 · Cited by 364
LEA proteins in higher plants: Structure, function, gene expression and regulation
Shao, H., Zong-Suo, L., & Ming-An, S. (2005) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2005.07.017 · Cited by 298
Saéz, Á., Robert, N., Maktabi, M. H., Schroeder, J. I., Serrano, R., & Rodrı́guez, P. L. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.081018 · Cited by 269
Candat, A., Paszkiewicz, G., Neveu, M., Gautier, R., Logan, D. C., Avelange‐Macherel, M., & Macherel, D. (2014) · The Plant Cell · doi:10.1105/tpc.114.127316 · Cited by 241
Aubert, Y., Vile, D., Pervent, M., et al. (2010) · Plant and Cell Physiology · doi:10.1093/pcp/pcq155 · Cited by 233
Tang, N., Ma, S., Zong, W., Yang, N., Lv, Y., Chun, Y., Guo, Z., Li, J., Li, X., Xiang, Y., et al. (2016) · The Plant Cell · doi:10.1105/tpc.16.00171 · Cited by 193
The Pepper Lipoxygenase CaLOX1 Plays a Role in Osmotic, Drought and High Salinity Stress Response
Lim, C. W., Han, S., Hwang, I. S., et al. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv020 · Cited by 175
Self-citationAn LEA group 3 family member is involved in survival of C. elegans during exposure to stress
Gal, T. Z., Glazer, I., & Koltai, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.049 · Cited by 155
Mizuno, T., & Yamashino, T. (2008) · Plant and Cell Physiology · doi:10.1093/pcp/pcn008 · Cited by 151
Wang, Z., Tian, X., Zhao, Q., Liu, Z., Li, X., Ren, Y., Tang, J., Fang, J., Xu, Q., & Bu, Q. (2017) · The Plant Cell · doi:10.1105/tpc.17.00823 · Cited by 145
Developmental Biochemistry of Cottonseed Embryogenesis and Germination
Dure, L. S., & Chlan, C. A. (1981) · PLANT PHYSIOLOGY · doi:10.1104/pp.68.1.180 · Cited by 126
Life without water: expression of plant LEA genes by an anhydrobiotic arthropod
Hand, S. C., Jones, D., Menze, M. A., & Witt, T. L. (2006) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.a.343 · Cited by 105
Yu, L., Wu, J., Zhang, Z., et al. (2017) · Molecular Plant · doi:10.1016/j.molp.2017.04.004 · Cited by 95
Water stress-regulated gene expression in Cicer arietinum seedlings and plants
Romo, S., Labrador, E., & Dopico, B. (2001) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(01)01318-3 · Cited by 75
Lim, C. W., Baek, W., & Lee, S. C. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.01817 · Cited by 75
Self-citationHuang, L., Zhang, M., Jia, J. T., et al. (2018) · Plant and Cell Physiology · doi:10.1093/pcp/pcy035 · Cited by 73
Campos, F., Cuevas‐Velazquez, C. L., Fares, M. A., et al. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0768-2 · Cited by 72
Lu, P., Magwanga, R. O., Guo, X., Kirungu, J. N., Lu, H., Cai, X., Zhou, Z., Wei, Y., Wang, X., Zhang, Z., et al. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200232 · Cited by 62
Magwanga, R. O., Lu, P., Kirungu, J. N., Dong, Q., Hu, Y., Zhou, Z., Cai, X., Wang, X., Hou, Y., Wang, K., et al. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200423 · Cited by 58
Park, C., Lim, C. W., Baek, W., & Lee, S. C. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv103 · Cited by 55
Self-citationLim, C. W., Lim, S., Baek, W., & Lee, S. C. (2014) · Physiologia Plantarum · doi:10.1111/ppl.12298 · Cited by 49
Self-citationLim, C. W., & Lee, S. C. (2016) · Plant Cell & Environment · doi:10.1111/pce.12721 · Cited by 49
Self-citationUnusual sequences of group 3 LEA mRNA inducible by maturation or drying in soybean seeds
Hsing, Y.-I. C., Chen, Z.-Y., Shih, M., et al. (1995) · Plant Molecular Biology · doi:10.1007/bf00041175 · Cited by 36
Goda, H., Sasaki, E., Akiyama, K., et al. (2008) · The Plant Journal · doi:10.1111/j.0960-7412.2008.03510.x · Cited by 36
Hong, E., Lim, C. W., Han, S.-W., & Lee, S. C. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01407 · Cited by 29
Self-citationJoo, H., Lim, C. W., & Lee, S. C. (2016) · Scientific Reports · doi:10.1038/srep30097 · Cited by 23
Self-citationBaek, W., Lim, C. W., & Lee, S. C. (2017) · Plant Cell & Environment · doi:10.1111/pce.13039 · Cited by 23
Self-citationPathak, N., & Ikeno, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.091 · Cited by 16
Surgical treatment of pectus excavatum: 30 years 398 patients of experiences
Hu, T., Li, Y., Liu, W., et al. (2008) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2008.02.075 · Cited by 15
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Emerging applications of gene editing technologies for the development of climate-resilient crops
Chavhan, R. L., Jaybhaye, S. G., Hinge, V. R., Deshmukh, A. S., Shaikh, U. S., Jadhav, P. K., Kadam, U. S., & Hong, J. C. (2025) · Frontiers in Genome Editing · doi:10.3389/fgeed.2025.1524767 · Cited by 55
Metadata
- Authors
- Lim, J., Lim, C. W., & Lee, S. C.
- Affiliations
- Chung-Ang University (KR)
- Corresponding author
- Lee, Sung Chul
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2018-09-04
- Volume
- 9
- Pages
- 1301-1301
- ISSN
- 1664-462X (ISSN-L)
- PMC
- PMC6131619
- OpenAlex
- W2891583475
- Cited by
- 27
- References
- 54
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 4 · 2020: 3 · 2019: 2
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Plant Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Seed Germination and Physiology
- Physical Sciences › Environmental Science › Global and Planetary Change › Plant Water Relations and Carbon Dynamics
- Keywords
- late embryogenesis abundant proteins, drought tolerance, abscisic acid signaling, transpiration, stomatal regulation, pepper, Capsicum annuum, gene overexpression, gene silencing, water loss
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