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Cited by 28Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeural and Behavioral Psychology Studies

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Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients

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Palermo, Sara, Lopiano, Leonardo, Morese, Rosalba, Zibetti, Maurizio, Romagnolo, Alberto, Stanziano, Mario, Rizzone, Mario Giorgio, Geminiani, Giuliano Carlo, Valentini, Maria Consuelo, Amanzio, Martina·2018·Frontiers in Psychology
DOI 10.3389/fpsyg.2018.01765PMC PMC6159748
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Abstract

Objectives: The detection of dyskinesias-reduced-self-awareness (DRSA) in Parkinson’s disease (PD) was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC) is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioral contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI) over the course of a specific executive task. Methods: Twenty-seven cognitively preserved idiopathic PD patients - presenting motor fluctuations and dyskinesias - were studied. They underwent a neurological and neuropsychological evaluation. The presence of DRSA was assessed using the Dyskinesias Subtracted-Index (DS-I). Cingulate functionality was evaluated with fMRI, while patients performed an ACC-sensitive GO-NoGO task. Association between blood oxygenation level dependent response over the whole-brain during the response-inhibition task and DS-I scores was investigated by regression analysis. Results: The presence of DRSA was associated with reduced functional recruitment in the bilateral ACC, bilateral anterior insular cortex and right dorsolateral prefrontal cortex (pFWE<.05). Moreover, DS-I scores significantly correlated with percent errors on the NoGO condition (r=.491, pFWE=.009). Discussion: These preliminary findings add evidence to the relevant role of executive dysfunctions in DRSA pathogenesis beyond the effects of chronic dopaminergic treatment, with a key leading role played by ACC as part of a functionally impaired response-inhibition network. Imaging biomarkers for DRSA are important to be studied, especially when the neuropsychological assessment seems to be normal.

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Metadata

Authors
Palermo, S., Lopiano, L., Morese, R., Zibetti, M., Romagnolo, A., Stanziano, M., Rizzone, M. G., Geminiani, G. C., Valentini, M. C., & Amanzio, M.
Affiliations
  • University of Turin (IT)
  • Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
Corresponding author
Morese, Rosalba
ORCID
Venue
Frontiers in Psychology
Publisher
Frontiers Media SA
Published
2018-09-20
Volume
9
Pages
1765-1765
ISSN
1664-1078 (ISSN-L)
DOI
10.3389/fpsyg.2018.01765
PMC
PMC6159748
OpenAlex
W2890580927
Cited by
28
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 8 · 2019: 6
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Psychology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Collegio Carlo Alberto
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
Parkinson's disease, anterior cingulate cortex, response inhibition, executive dysfunction, metacognition, self-awareness, anterior insula, dorsolateral prefrontal cortex, go/no-go task, mesocorticolimbic circuit, imaging biomarkers

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