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Cited by 42Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats

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Wang, Rui, Wang, Wei, Xu, Jingjing, Liu, Dexiang, Jiang, Hong, Pan, Fang·2018·Frontiers in Psychiatry
DOI 10.3389/fpsyt.2018.00471PMC PMC6193509
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Abstract

Aims: Expression of inflammatory cytokines in the brain has been reported to be involved in the pathogenesis of and susceptibility to depression. Jumonji domain containing-3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a crucial element in the expression of inflammatory cytokines. Furthermore, recent studies highlighted the fact that lipopolysaccharides induce depressive-like behaviors and higher Jmjd3 expression and lower H3K27me3 expression in the brain. However, whether Jmjd3 mediating inflammatory cytokine was involved in the susceptibility to depression caused by early life stress remained elusive. Methods: Rats exposed to chronic unpredictable mild stress (CUMS) in adolescence were used in order to detect dynamic alterations in depressive-like behaviors and expression of cytokines, Jmjd3, and H3K27me3 in the prefrontal cortex and hippocampus. Moreover, minocycline, an inhibitor of microglial activation, was employed to observe the protective effects. Results: Our results showed that CUMS during the adolescent period induced depressive-like behaviors, over-expression of cytokines, and increased Jmjd3 and decreased H3K27me3 expression in the prefrontal cortex and hippocampus of both adolescent and adult rats. However, minocycline relieved all the alterations. Conclusion: The study revealed that JMJD3 might be involved in the susceptibility to depressive-like behaviors by modulating H3K27me3 and pro-inflammatory cytokine expression in the prefrontal cortex and hippocampus of rats that had been stressed during early adolescence.

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Cited by

Sorted by citations

Authors
Wang, R., Wang, W., Xu, J., Liu, D., Jiang, H., & Pan, F.
Affiliations
Shandong University (CN)
Corresponding author
Pan, Fang
ORCID
Venue
Frontiers in Psychiatry
Publisher
Frontiers Media SA
Published
2018-10-11
Volume
9
Pages
471-471
ISSN
1664-0640 (ISSN-L)
DOI
10.3389/fpsyt.2018.00471
PMC
PMC6193509
OpenAlex
W3005836785
Cited by
42
References
9
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 1 · 2018: 1
FWCI
1.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Psychiatry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (31371036, 31771220)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
early life stress, depression-like behavior, JMJD3, H3K27me3, histone demethylation, inflammatory cytokines, microglial activation, minocycline, prefrontal cortex, hippocampus, depression vulnerability, neuroinflammation

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