Cited by 393Dementia and Cognitive Impairment ResearchArtificial Intelligence in HealthcareAlzheimer's disease research and treatments

Early-Stage Alzheimer’s Disease Prediction Using Machine Learning Models

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Kavitha, C., Mani, Vinodhini, Srividhya, S. R., Khalaf, Osamah Ibrahim, Tavera Romero, Carlos Andrés·2022·Frontiers in Public Health

Abstract

Alzheimer's disease (AD) is the leading cause of dementia in older adults. There is currently a lot of interest in applying machine learning to find out metabolic diseases like Alzheimer's and Diabetes that affect a large population of people around the world. Their incidence rates are increasing at an alarming rate every year. In Alzheimer's disease, the brain is affected by neurodegenerative changes. As our aging population increases, more and more individuals, their families, and healthcare will experience diseases that affect memory and functioning. These effects will be profound on the social, financial, and economic fronts. In its early stages, Alzheimer's disease is hard to predict. A treatment given at an early stage of AD is more effective, and it causes fewer minor damage than a treatment done at a later stage. Several techniques such as Decision Tree, Random Forest, Support Vector Machine, Gradient Boosting, and Voting classifiers have been employed to identify the best parameters for Alzheimer's disease prediction. Predictions of Alzheimer's disease are based on Open Access Series of Imaging Studies (OASIS) data, and performance is measured with parameters like Precision, Recall, Accuracy, and F1-score for ML models. The proposed classification scheme can be used by clinicians to make diagnoses of these diseases. It is highly beneficial to lower annual mortality rates of Alzheimer's disease in early diagnosis with these ML algorithms. The proposed work shows better results with the best validation average accuracy of 83% on the test data of AD. This test accuracy score is significantly higher in comparison with existing works.

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Research works printed but not linked: 3

  1. [9]Sulaiman N Abdulsahib G Khalaf O Mohammed MN. “Effect of Using Different Propagations of OLSR and DSDV Routing Protocols”, In Proceedings of the IEEE International Conference on Intelligent Systems Structureing and Simulation. (2014), pp. 540– 5.
  2. [14]National National Academies of Sciences Engineering and Medicine. Preventing cognitive decline and dementia: A way forward. London: The National Academies Press (2018). 28650595
  3. [22]Sudharsan M Thailambal G. Alzheimer's disease prediction using machine learning techniques and principal component analysis (PCA), Materials Today: Proceedings (2021).

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Authors
Kavitha, C., Mani, V., Srividhya, S. R., Khalaf, O. I., & Tavera Romero, C. A.
Affiliations
  • Sathyabama Institute of Science and Technology (IN)
  • Nahrain University (IQ)
Corresponding author
Kavitha, C.
Venue
Frontiers in Public Health
Published
2022-03-03
Volume
10
Pages
853294-853294
ISSN
2296-2565 (ISSN-L)
OpenAlex
W4214898695
Cited by
373
References
30
Citations by year
2026: 64 · 2025: 135 · 2024: 90 · 2023: 56 · 2022: 28
FWCI
50.29
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Universidad Santiago de Cali (01-2021)
  • National Institute on Aging (P01AG003991)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, dementia, OASIS dataset, neuroimaging, machine learning classification, random forest, gradient boosting, support vector machine, decision tree, voting classifier, early diagnosis
MeSH terms
Machine Learning, Aged, Alzheimer Disease, Brain, Humans, Magnetic Resonance Imaging, Cognitive Dysfunction

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