Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 317

The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.

Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review

Open access
Ma, Xinru, Zhou, Shiyu, Xu, Xiaoling, Du, Qin·2022·Frontiers in Surgery
DOI 10.3389/fsurg.2022.905892
Open this paper in CoChat — free account

Abstract

Copper has been used as an antimicrobial agent long time ago. Nowadays, copper-containing nanoparticles (NPs) with antimicrobial properties have been widely used in all aspects of our daily life. Copper-containing NPs may also be incorporated or coated on the surface of dental materials to inhibit oral pathogenic microorganisms. This review aims to detail copper-containing NPs’ antimicrobial mechanism, cytotoxic effect and their application in dentistry.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fsurg.2022.905892

Cites

167 of 167 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 167 references

Research works printed but not linked: 34

  1. Mainz, 2015, The metals of antiquity and their alloys, Chem Technol Antiq, 1211, 139, 10.1021/bk-2015-1211.ch005 · doi:10.1021/bk-2015-1211.ch005
  2. Sarsan, 2013, Effect of storage of water in different metal vessels on coliforms, Int J Curr Microbiol Appl Sci, 2, 24
  3. Shimizu, 2008, Resin-bonded castings with a cingulum rest seat and a guide plane for a removable partial denture: a case report, Quintessence Int (Berl), 39, e11, 10.1111/j.1600-0757.2007.00243.x · doi:10.1111/j.1600-0757.2007.00243.x
  4. El Zowalaty, 2013, Synthesis, characterization, and antimicrobial properties of copper nanoparticles, Int J Nanomed, 8, 4467, 10.2147/IJN.S50837 · doi:10.2147/ijn.s50837
  5. Pugazhendhi, 2018, Photocatalytic properties and antimicrobial efficacy of Fe doped CuO nanoparticles against the pathogenic bacteria and fungi, Microb Pathog, 122, 84, 10.1016/j.micpath.2018.06.016 · doi:10.1016/j.micpath.2018.06.016
  6. Erci, 2020, Synthesis of biologically active copper oxide nanoparticles as promising novel antibacterial-antibiofilm agents, Prep Biochem Biotechnol, 50, 538, 10.1080/10826068.2019.1711393 · doi:10.1080/10826068.2019.1711393
  7. Arakawa, 2019, Development of a new vacuum impregnation method at room atmosphere to produce silver-copper oxide nanoparticles on activated carbon for antibacterial applications, Environ Technol, 41, 2400, 10.1080/09593330.2019.1567607 · doi:10.1080/09593330.2019.1567607
  8. Zhou, 2021, In situ deposition of nano CuO on electrospun chitosan nanofibrous scaffolds and their antimicrobial properties, Int J Biol Macromol, 9, 121, 10.1016/j.ijbiomac.2021.09.121 · doi:10.1016/j.ijbiomac.2021.09.121
  9. Saleh, 2021, Antibacterial functionalization of cotton and cotton/polyester fabrics applying hybrid coating of copper/chitosan nanocomposites loaded polymer blends via gamma irradiation, Int J Biol Macromol, 183, 23, 10.1016/j.ijbiomac.2021.04.059 · doi:10.1016/j.ijbiomac.2021.04.059
  10. Ulloa-Ogaz, 2018, Oxidative damage to pseudomonas aeruginosa atcc 27833 and staphylococcus aureus atcc 24213 induced by cuo-nps, Environ Sci Pollut Res Int, 24, 22048, 10.1007/s11356-017-9718-6 · doi:10.1007/s11356-017-9718-6
  11. Denluck, 2018, Reactive oxygen species generation is likely a driver of copper-based nanomaterial toxicity, Environ Sci, 5, 1473, 10.1039/C8EN00055G · doi:10.1039/c8en00055g
  12. Bao, 2015, Assessment of the toxicity of cuo nanoparticles by using saccharomyces cerevisiae mutants with multiple genes deleted, Appl Environ Microbiol., 81, 8098, 10.1128/AEM.02035-15 · doi:10.1128/aem.02035-15
  13. Yuzer, 2021, Photocatalytic, self-cleaning and antibacterial properties of Cu(II) doped TiO, J Environ Manage, 302, 114023, 10.1016/j.jenvman.2021.114023 · doi:10.1016/j.jenvman.2021.114023
  14. Morsy, 2021, Cytotoxicity and genotoxicity of copper oxide nanoparticles in chickens, Biol Trace Elem Res, 23, 1, 10.1007/s12011-021-02595-4 · doi:10.1007/s12011-021-02595-4
  15. Xiong, 2015, Morphology-dependent antimicrobial activity of Cu/CuxO nanoparticles, Ecotoxicology, 24, 2067, 10.1007/s10646-015-1554-1 · doi:10.1007/s10646-015-1554-1
  16. Feng, 2017, Understanding the property-activity relationships of polyhedral cuprous oxide nanocrystals in terms of reactive crystallographic facets, Toxicol Sci, 156, 480, 10.1093/toxsci/kfx011 · doi:10.1093/toxsci/kfx011
  17. Jung, 2015, Morphology-controlled synthesis of octahedral-to-rhombic dodecahedral Cu2O microcrystals and shape-dependent antibacterial activities, Bull Korean Chem Soc, 36, 1828, 10.1002/bkcs.10351 · doi:10.1002/bkcs.10351
  18. Lee, 2011, Morphology-dependent antibacterial activities of Cu2O, Mater Lett, 65, 818, 10.1016/j.matlet.2010.12.023 · doi:10.1016/j.matlet.2010.12.023
  19. Qi, 2021, Copper phosphide nanoparticles used for combined photothermal and photodynamic tumor therapy, ACS Biomater Sci Eng, 7, 2745, 10.1021/acsbiomaterials.1c00189 · doi:10.1021/acsbiomaterials.1c00189
  20. Ishida, 2019, Reduction of the cytotoxicity of copper (II) oxide nanoparticles by coating with a surface-binding peptide, Appl Biochem Biotechnol, 190, 645, 10.1007/s12010-019-03108-9 · doi:10.1007/s12010-019-03108-9
  21. Alghobashy, 2018, Trace elements and oxidative stress in children with type 1 diabetes mellitus, Diab Metab Syndr Obes-Targets and Ther, 11, 85, 10.2147/DMSO.S157348 · doi:10.2147/dmso.s157348
  22. Semprine, 2014, Brain antioxidant responses to acute iron and copper intoxications in rats, Metallomics, 6, 2083, 10.1039/C4MT00159A · doi:10.1039/c4mt00159a
  23. Grytten, 1987, The effect of a combination of copper and hexetidine on plaque formation and the amount of copper retained by dental plaque bacteria, Acta Odontol Scand, 45, 429, 10.3109/00016358709096368 · doi:10.3109/00016358709096368
  24. Maltz, 1988, Effect of copper fluoride and copper sulfate on dental plaque, Streptococcus mutans and caries in hamsters, Eur J Oral Sci, 96, 390, 10.1111/j.1600-0722.1988.tb01572.x · doi:10.1111/j.1600-0722.1988.tb01572.x
  25. Bai, 2016, The anti-bacterial activity of titanium-copper sintered alloy against Porphyromonas gingivalis in vitro, Dent Mater J, 35, 659, 10.4012/dmj.2016-001 · doi:10.4012/dmj.2016-001
  26. 2022, Spray-dryingassisted fabrication of CaF/SiO nanoclusters for dental restorative composites, Dent Mater, 38, 835, 10.1016/j.dental.2022.04.007 · doi:10.1016/j.dental.2022.04.007
  27. Serkies, 2016, Matrix metalloproteinase inhibitor modulates esterase-catalyzed degradation of resin–dentin interfaces, Dent Mater, 32, 1513, 10.1016/j.dental.2016.09.007 · doi:10.1016/j.dental.2016.09.007
  28. Aguilar-Perez, 2020, Antibacterial activity of a glass ionomer cement doped with copper nanoparticles, Dent Mater J, 39, 389, 10.4012/dmj.2019-046 · doi:10.4012/dmj.2019-046
  29. El Saeed, 2016, Synthesis of cuprous oxide epoxy nanocomposite as an environmentally antimicrobial coating, Int J Biol Macromol, 89, 190, 10.1016/j.ijbiomac.2016.04.043 · doi:10.1016/j.ijbiomac.2016.04.043
  30. Nguyen, 2021, Development of antimicrobial CuO/(3-aminopropyl)Triethoxysilane activated carbon fiber, J Nanosci Nanotechnol, 21, 4519, 10.1166/jnn.2021.19428 · doi:10.1166/jnn.2021.19428
  31. Deokar, 2021, Antibacterial and in vivo studies of a green, one-pot preparation of copper/zinc oxide nanoparticle-coated bandages, Membranes, 11, 462, 10.3390/membranes11070462 · doi:10.3390/membranes11070462
  32. Ghosh, 2019, Antibacterial copper-hydroxyapatite composite coatings via electrochemical synthesis, Langmuir, 35, 5957, 10.1021/acs.langmuir.9b00919 · doi:10.1021/acs.langmuir.9b00919
  33. Ahrari, 2015, The antimicrobial sensitivity of streptococcus mutans and streptococcus sangius to colloidal solutions of different nanoparticles applied as mouthwashes, Dent Res J (Isfahan), 12, 44, 10.4103/1735-3327.150330 · doi:10.4103/1735-3327.150330
  34. Ansarifard, 2021, Evaluation of antimicrobial and antibiofilm activities of copper oxide nanoparticles within soft denture liners against oral pathogens, Bioinorg Chem Appl, 2021, 9939275, 10.1155/2021/9939275 · doi:10.1155/2021/9939275

Cited by

See all 317

Metadata

Authors
Ma, X., Zhou, S., Xu, X., & Du, Q.
Venue
Frontiers in Surgery
Publisher
Frontiers Media SA
Published
2022-08-05
Volume
9
Pages
905892-905892
ISSN
2296-875X (ISSN-L)
DOI
10.3389/fsurg.2022.905892
OpenAlex
W4289866408
Cited by
317
References
167
FWCI
2.52
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Foundation in Science and Technology office of Sichuan Province (2021YFG0230)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review. https://app.cochat.ai/papers/10.3389/fsurg.2022.905892
The paper
Ma, X., Zhou, S., Xu, X., & Du, Q. (2022). Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review. Frontiers in Surgery. https://doi.org/10.3389/fsurg.2022.905892

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.