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Cited by 121Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Associative and non-associative plasticity in Kenyon cells of the honeybee mushroom body

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Szyszka, Paul·2008·Frontiers in Systems Neuroscience
DOI 10.3389/neuro.06.003.2008PMC PMC2526274
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Abstract

The insect mushroom bodies are higher-order brain centers and critical for odor learning. We investigated experience dependent plasticity of their intrinsic neurons, the Kenyon cells (KCs). Using calcium imaging, we recorded KC responses and investigated non-associative plasticity by applying repeated odor stimuli. Associative plasticity was examined by performing appetitive odor learning experiments. Olfactory, gustatory and tactile antennal stimuli evoked phasic calcium transients in sparse ensembles of responding KCs. Repeated stimulation with an odor led to a decrease in KCs' response strength. The pairing of an odor (conditioned stimulus, CS) with a sucrose reward (unconditioned stimulus) induced a prolongation of KC responses. After conditioning, KC responses to a rewarded odor (CS+) recovered from repetition-induced decrease, while the responses to a non-rewarded odor (CS-) decreased further. The spatio-temporal pattern of activated KCs changed for both odors when compared with the response before conditioning but the change was stronger for the CS-. These results demonstrate that KC responses are subject to non-associative plasticity during odor repetition and undergo associative plasticity after appetitive odor learning.

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  • Hebbian-like plasticity in connections at the output of the mushroom body can support various forms of reinforcement learning.

    “It is well established that Hebbian-like plasticity in connections at the output of the mushroom body can support various forms of reinforcement learning [71,76–78].”

    From Phenomenal interface theory: a model for basal consciousness (2025) · cites this paper as [77]

    The Introduction (page unavailable) describes learning-related plasticity in mushroom-body neurons, and the Discussion reports associative plasticity in Kenyon-cell responses during rewarded odor learning. But the paper investigates responses at the mushroom body's input region; it does not establish Hebbian-like plasticity at output connections or show that such plasticity supports various forms of reinforcement learning. (LLM, conf=0.83)

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Authors
Szyszka, P.
Affiliations
University of Konstanz (DE)
Corresponding author
Szyszka, Paul
ORCID
Szyszka, Paul
Venue
Frontiers in Systems Neuroscience
Publisher
Frontiers Media SA
Published
2008
Volume
2
Pages
3-3
ISSN
1662-5137 (ISSN-L)
DOI
10.3389/neuro.06.003.2008
PMC
PMC2526274
OpenAlex
W2022062647
Cited by
121
References
45
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 15 · 2012: 12
FWCI
3.17
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • KOPS (University of Konstanz) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Deutsche Forschungsgemeinschaft (SFB 515)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Kenyon cells, associative plasticity, non-associated plasticity, olfactory conditioning, sucrose reward, calcium imaging

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