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Cited by 339

The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.

Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

Open access
Karampatakis, Theodoros, Tsergouli, Katerina, Behzadi, Payam·2023·Antibiotics
DOI 10.3390/antibiotics12020234
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Abstract

Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety of community and hospital infections. Infections caused by carbapenem-resistant K. pneumoniae (CRKP) constitute a major threat for public health and are strongly associated with high rates of mortality, especially in immunocompromised and critically ill patients. Adhesive fimbriae, capsule, lipopolysaccharide (LPS), and siderophores or iron carriers constitute the main virulence factors which contribute to the pathogenicity of K. pneumoniae. Colistin and tigecycline constitute some of the last resorts for the treatment of CRKP infections. Carbapenemase production, especially K. pneumoniae carbapenemase (KPC) and metallo-β-lactamase (MBL), constitutes the basic molecular mechanism of CRKP emergence. Knowledge of the mechanism of CRKP appearance is crucial, as it can determine the selection of the most suitable antimicrobial agent among those most recently launched. Plazomicin, eravacycline, cefiderocol, temocillin, ceftolozane–tazobactam, imipenem–cilastatin/relebactam, meropenem–vaborbactam, ceftazidime–avibactam and aztreonam–avibactam constitute potent alternatives for treating CRKP infections. The aim of the current review is to highlight the virulence factors and molecular pathogenesis of CRKP and provide recent updates on the molecular epidemiology and antimicrobial treatment options.

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Metadata

Authors
Karampatakis, T., Tsergouli, K., & Behzadi, P.
Venue
Antibiotics
Publisher
MDPI AG
Published
2023-01-21
Volume
12
Issue
2
Pages
234
ISSN
2079-6382 (ISSN-L)
DOI
10.3390/antibiotics12020234
OpenAlex
W4317931744
Cited by
339
References
167
FWCI
23.95
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options. https://app.cochat.ai/papers/10.3390/antibiotics12020234
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Karampatakis, T., Tsergouli, K., & Behzadi, P. (2023). Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options. Antibiotics. https://doi.org/10.3390/antibiotics12020234

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.