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Cited by 313

The DOI matches its Crossref record; 300 of the 300 references it cites were found in a registry or an index.

Changes in Glutathione Content in Liver Diseases: An Update

Open access
Vairetti, Mariapia, Di Pasqua, Laura Giuseppina, Cagna, Marta, Richelmi, Plinio, Ferrigno, Andrea, Berardo, Clarissa·2021·Antioxidants
DOI 10.3390/antiox10030364
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Abstract

Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important thiol reducing agent involved in the modulation of redox processes. It has also been demonstrated that GSH cannot be considered only as a mere free radical scavenger but that it takes part in the network governing the choice between survival, necrosis and apoptosis as well as in altering the function of signal transduction and transcription factor molecules. The purpose of the present review is to provide an overview on the molecular biology of the GSH system; therefore, GSH synthesis, metabolism and regulation will be reviewed. The multiple GSH functions will be described, as well as the importance of GSH compartmentalization into distinct subcellular pools and inter-organ transfer. Furthermore, we will highlight the close relationship existing between GSH content and the pathogenesis of liver disease, such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), chronic cholestatic injury, ischemia/reperfusion damage, hepatitis C virus (HCV), hepatitis B virus (HBV) and hepatocellular carcinoma. Finally, the potential therapeutic benefits of GSH and GSH-related medications, will be described for each liver disorder taken into account.

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Metadata

Authors
Vairetti, M., Di Pasqua, L. G., Cagna, M., Richelmi, P., Ferrigno, A., & Berardo, C.
Venue
Antioxidants
Publisher
MDPI AG
Published
2021-02-28
Volume
10
Issue
3
Pages
364
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox10030364
OpenAlex
W3134873082
Cited by
313
References
300
FWCI
13.80
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Changes in Glutathione Content in Liver Diseases: An Update. https://app.cochat.ai/papers/10.3390/antiox10030364
The paper
Vairetti, M., Di Pasqua, L. G., Cagna, M., Richelmi, P., Ferrigno, A., & Berardo, C. (2021). Changes in Glutathione Content in Liver Diseases: An Update. Antioxidants. https://doi.org/10.3390/antiox10030364

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.