Myeloperoxidase Inhibition Ameliorates Plaque Psoriasis in Mice
Open accessAbstract
Plaque psoriasis is a common inflammatory condition of the skin characterized by red, flaking lesions. Current therapies for plaque psoriasis target many facets of the autoimmune response, but there is an incomplete understanding of how oxidative damage produced by enzymes such as myeloperoxidase contributes to skin pathology. In this study, we used the Aldara (Imiquimod) cream model of plaque psoriasis in mice to assess myeloperoxidase inhibition for treating psoriatic skin lesions. To assess skin inflammation severity, an innovative mouse psoriasis scoring system was developed. We found that myeloperoxidase inhibition ameliorated psoriasis severity when administered either systemically or topically. The findings of this study support the role of oxidative damage in plaque psoriasis pathology and present potential new therapeutic avenues for further exploration.
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The MPO system has been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis.
“beyond a role in cutaneous innate immunity, the MPO system has also been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis (51–59).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [59]
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- Authors
- Neu, S. D., Strzepa, A., Martin, D., Sorci-Thomas, M. G., Pritchard, K. A., & Dittel, B. N.
- Affiliations
- Medical College of Wisconsin (US)
- Versiti Blood Research Institute, Milwaukee, WI 53201, USA
- Department of Medicine, Division of Endocrinology & Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
- Versiti Blood Center of Wisconsin (US)
- Corresponding author
- Dittel, Bonnie N.
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-08-25
- Volume
- 10
- Issue
- 9
- Pages
- 1338
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8472607
- OpenAlex
- W3194426002
- Cited by
- 40
- References
- 66
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 9 · 2023: 1 · 2022: 4
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Allergy and Infectious Diseases (1R56AI129348, 1R56AI122655)
- National Multiple Sclerosis Society (RG 4975A1/2)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- plaque psoriasis, myeloperoxidase inhibition, oxidative stress, imiquimod-induced psoriasis, topical treatment, systemic therapy, skin inflammation, psoriatic lesions
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