Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 18

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia

Lin, Erika T., Bae, Yeunook, Birkett, Robert, Sharma, Abhineet M., Zhang, Runze, Fisch, Kathleen M., Funk, William, Mestan, Karen K.·2024·Antioxidants
DOI 10.3390/antiox13040494
Open this paper in CoChat — free account

Abstract

Fetal and neonatal exposures to perinatal oxidative stress (OS) are key mediators of bronchopulmonary dysplasia (BPD). To characterize these exposures, adductomics is an exposure science approach that captures electrophilic addition products (adducts) in blood protein. Adducts are bound to the nucleophilic cysteine loci of human serum albumin (HSA), which has a prolonged half-life. We conducted targeted and untargeted adductomics to test the hypothesis that adducts of OS vary with BPD. We studied 205 preterm infants (≤28 weeks) and 51 full-term infants from an ongoing birth cohort. Infant plasma was collected at birth (cord blood), 1-week, 1-month, and 36-weeks postmenstrual age. HSA was isolated from plasma, trypsin digested, and analyzed using high-performance liquid chromatography–mass spectrometry to quantify previously annotated (known) and unknown adducts. We identified 105 adducts in cord and postnatal blood. A total of 51 known adducts (small thiols, direct oxidation products, and reactive aldehydes) were increased with BPD. Postnatally, serial concentrations of several known OS adducts correlated directly with supplemental oxygen exposure. The application of large-scale adductomics elucidated OS-mediated pathways of BPD. This is the first study to investigate the “neonatal–perinatal exposome” and to identify oxidative stress-related exposure biomarkers that may inform antioxidant strategies to protect the health of future generations of infants.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/antiox13040494

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 55

  1. Siffel, 2021, Global incidence of bronchopulmonary dysplasia among extremely preterm infants: A systematic literature review, J. Matern. Fetal. Neonatal Med., 34, 1721, 10.1080/14767058.2019.1646240 · DOI
  2. Cuestas, 2018, Sustained Neonatal Inflammation Is Associated with Poor Growth in Infants Born Very Preterm during the First Year of Life, J. Pediatr., 205, 91, 10.1016/j.jpeds.2018.09.032 · DOI
  3. Wandalsen, 2018, Pulmonary function in former very low birth weight preterm infants in the first year of life, Respir. Med., 136, 83, 10.1016/j.rmed.2018.02.004 · DOI
  4. Silva, 2018, Assessment of the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia, Rev. Bras. Ter. Intensiv., 30, 174, 10.5935/0103-507X.20180023 · DOI
  5. Walsh, 2017, Neonatal outcomes of moderately preterm infants compared to extremely preterm infants, Pediatr. Res., 82, 297, 10.1038/pr.2017.46 · DOI
  6. Jensen, 2022, Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia, Semin. Perinatol., 46, 151638, 10.1016/j.semperi.2022.151638 · DOI
  7. Parsons, 2022, Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia, Am. J. Physiol. Cell Mol. Physiol., 323, L651, 10.1152/ajplung.00204.2022 · DOI
  8. Wang, 2018, Oxidative stress and bronchopulmonary dysplasia, Gene, 678, 177, 10.1016/j.gene.2018.08.031 · DOI
  9. Buonocore, 2012, Oxidative stress and bronchopulmonary dysplasia, J. Clin. Neonatol., 1, 109, 10.4103/2249-4847.101683 · DOI
  10. Davis, 2002, Role of oxidant injury in the pathogenesis of neonatal lung disease, Acta Paediatr. Suppl., 91, 23, 10.1111/j.1651-2227.2002.tb00156.x · DOI
  11. Cheah, 2008, Oxidative Stress in Fetal Lambs Exposed to Intra-amniotic Endotoxin in a Chorioamnionitis Model, Pediatr. Res., 63, 274, 10.1203/PDR.0b013e31815f653b · DOI
  12. Rappaport, 2012, Adductomics: Characterizing exposures to reactive electrophiles, Toxicol. Lett., 213, 83, 10.1016/j.toxlet.2011.04.002 · DOI
  13. Grigoryan, 2016, Adductomics Pipeline for Untargeted Analysis of Modifications to Cys34 of Human Serum Albumin, Anal. Chem., 88, 10504, 10.1021/acs.analchem.6b02553 · DOI
  14. Grigoryan, 2012, Cys34 adducts of reactive oxygen species in human serum albumin, Chem. Res. Toxicol., 25, 1633, 10.1021/tx300096a · DOI
  15. Mestan, 2017, Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension, J. Pediatr., 185, 33, 10.1016/j.jpeds.2017.01.015 · DOI
  16. Voller, 2014, Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth: A preterm birth cohort study, Early Hum. Dev., 90, 195, 10.1016/j.earlhumdev.2014.01.003 · DOI
  17. Sharma, 2022, Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth, J. Clin. Investig., 7, 155482
  18. Jones, 2021, Evaluating definitions for maternal fever as diagnostic criteria for intraamniotic infection in low-risk pregnancies, Birth, 48, 389, 10.1111/birt.12548 · DOI
  19. Kim, 2015, Acute chorioamnionitis and funisitis: Definition, pathologic features, and clinical significance, Am. J. Obstet. Gynecol., 213, S29, 10.1016/j.ajog.2015.08.040 · DOI
  20. Palmsten, 2018, Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study, Placenta, 67, 54, 10.1016/j.placenta.2018.06.001 · DOI
  21. Fenton, T.R. (2003). A new growth chart for preterm babies: Babson and Benda’s chart updated with recent data and a new format. BMC Pediatr., 3. · DOI
  22. Higgins, 2018, Bronchopulmonary Dysplasia: Executive Summary of a Workshop, J. Pediatr., 197, 300, 10.1016/j.jpeds.2018.01.043 · DOI
  23. Mestan, 2014, Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension, Placenta, 35, 570, 10.1016/j.placenta.2014.05.003 · DOI
  24. Wai, 2016, Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns, J. Pediatr., 177, 97, 10.1016/j.jpeds.2016.06.079 · DOI
  25. Funk, 2021, Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy, Front. Public Health, 9, 730369, 10.3389/fpubh.2021.730369 · DOI
  26. Wong, 2022, Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin, Environ. Toxicol. Pharmacol., 95, 103966, 10.1016/j.etap.2022.103966 · DOI
  27. Petrick, 2020, Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome, Curr. Opin. Pediatr., 32, 300, 10.1097/MOP.0000000000000875 · DOI
  28. Law, 2016, RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR, F1000Research, 5, 1408, 10.12688/f1000research.9005.1 · DOI
  29. Carlsson, H., Rappaport, S.M., and Törnqvist, M. (2019). Protein Adductomics: Methodologies for Untargeted Screening of Adducts to Serum Albumin and Hemoglobin in Human Blood Samples. High Throughput, 8. · DOI
  30. Grigoryan, 2018, Adductomic signatures of benzene exposure provide insights into cancer induction, Carcinog., 39, 661, 10.1093/carcin/bgy042 · DOI
  31. Liu, 2018, Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London, Environ. Sci. Technol., 52, 2307, 10.1021/acs.est.7b05554 · DOI
  32. Lu, 2017, Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China, Environ. Sci. Technol., 51, 46, 10.1021/acs.est.6b03955 · DOI
  33. Yano, 2019, Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots, Anal. Bioanal. Chem., 411, 2351, 10.1007/s00216-019-01675-8 · DOI
  34. Yano, 2020, Untargeted adductomics of newborn dried blood spots identifies modifications to human serum albumin associated with childhood leukemia, Leuk. Res., 88, 106268, 10.1016/j.leukres.2019.106268 · DOI
  35. Grigoryan, 2021, Extending the HSA-Cys34-Adductomics Pipeline to Modifications at Lys525, Chem. Res. Toxicol., 34, 2549, 10.1021/acs.chemrestox.1c00311 · DOI
  36. Grigoryan, 2019, Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology, Cancer Res., 79, 6024, 10.1158/0008-5472.CAN-19-1529 · DOI
  37. Perez, 2019, Oxygen radical disease in the newborn, revisited: Oxidative stress and disease in the newborn period, Free. Radic. Biol. Med., 142, 61, 10.1016/j.freeradbiomed.2019.03.035 · DOI
  38. Deng, 2023, Molecular mechanisms of cell death in bronchopulmonary dysplasia, Apoptosis, 28, 39, 10.1007/s10495-022-01791-4 · DOI
  39. Ferrante, 2022, Antioxidants: Role the in prevention and treatment of bronchopulmonary dysplasia, Paediatr. Respir. Rev., 42, 53
  40. Oei, 2017, Higher or lower oxygen for delivery room resuscitation of preterm infants below 28 completed weeks gestation: A meta-analysis, Arch. Dis. Child. Fetal Neonatal Ed., 102, F24, 10.1136/archdischild-2016-310435 · DOI
  41. Kapadia, 2017, Impact of the Neonatal Resuscitation Program–Recommended Low Oxygen Strategy on Outcomes of Infants Born Preterm, J. Pediatr., 191, 35, 10.1016/j.jpeds.2017.08.074 · DOI
  42. Tagliaferro, 2019, Maternal preeclampsia and respiratory outcomes in extremely premature infants, Pediatr. Res., 85, 693, 10.1038/s41390-019-0336-5 · DOI
  43. Dravet-Gounot, P., Torchin, H., Goffinet, F., Aubelle, M.-S., El Ayoubi, M., Lefevre, C., Jarreau, P.-H., and Zana-Taïeb, E. (2018). Bronchopulmonary dysplasia in neonates born to mothers with preeclampsia: Impact of small for gestational age. PLoS ONE, 13. · DOI
  44. Elkabany, 2020, Oxidative stress markers in neonatal respiratory distress syndrome: Advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity, Pediatr. Res., 87, 74, 10.1038/s41390-019-0464-y · DOI
  45. Longini, 2017, Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood, Mediat. Inflamm., 2017, 1758432, 10.1155/2017/1758432 · DOI
  46. Wu, F., Tian, F.-J., and Lin, Y. (2015). Oxidative Stress in Placenta: Health and Diseases. BioMed Res. Int., 2015. · DOI
  47. Dizdar, 2011, Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome, Ann. Clin. Biochem., 48, 462, 10.1258/acb.2011.010285 · DOI
  48. Chung, 2014, Antibody enrichment and mass spectrometry of albumin-Cys34 adducts, Chem. Res. Toxicol., 27, 400, 10.1021/tx400337k · DOI
  49. Behl, T., Rachamalla, M., Najda, A., Sehgal, A., Singh, S., Sharma, N., Bhatia, S., Al-Harrasi, A., Chigurupati, S., and Vargas-De-La-Cruz, C. (2021). Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research. Int. J. Mol. Sci., 22. · DOI
  50. Ogihara, 1999, Raised concentrations of aldehyde lipid peroxidation products in premature infants with chronic lung disease, Arch. Dis. Child. Fetal Neonatal Ed., 80, F21, 10.1136/fn.80.1.F21 · DOI
  51. Stevens, 1992, Blood spot screening and confirmatory tests for syphilis antibody, J. Clin. Microbiol., 30, 2353, 10.1128/jcm.30.9.2353-2358.1992 · DOI
  52. Worthman, 1997, Hormone measures in finger-prick blood spot samples: New field methods for reproductive endocrinology, Am. J. Phys. Anthropol., 104, 1, 10.1002/(SICI)1096-8644(199709)104:1<1::AID-AJPA1>3.0.CO;2-V · DOI
  53. McDade, 2000, Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity, Psychosom. Med., 62, 560, 10.1097/00006842-200007000-00015 · DOI
  54. Jacobson, 2022, A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots, J. Expo. Sci. Environ. Epidemiol., 33, 505, 10.1038/s41370-022-00460-7 · DOI
  55. Jacobson, 2024, Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review, Environ. Sci. Technol., 58, 3580, 10.1021/acs.est.3c04981 · DOI

Cited by

See all 18

Metadata

Authors
Lin, E. T., Bae, Y., Birkett, R., Sharma, A. M., Zhang, R., Fisch, K. M., Funk, W., & Mestan, K. K.
Venue
Antioxidants
Publisher
MDPI AG
Published
2024-04-20
Volume
13
Issue
4
Pages
494
ISSN
2076-3921
DOI
10.3390/antiox13040494
Cited by
18
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Institute of Child Health and Human Development (NICHD) (R21HD100831, R01HL139798, UL1TR001442, S10OD025194, P41 GM108569)
  • National Heart, Lung, and Blood Institute (NHLBI) (R21HD100831, R01HL139798, UL1TR001442, S10OD025194, P41 GM108569)
  • National Center for Advancing Translational Sciences (R21HD100831, R01HL139798, UL1TR001442, S10OD025194, P41 GM108569)
  • NIH Office of Director (R21HD100831, R01HL139798, UL1TR001442, S10OD025194, P41 GM108569)
  • National Resource for Translational and Developmental Proteomics (R21HD100831, R01HL139798, UL1TR001442, S10OD025194, P41 GM108569)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia. https://app.cochat.ai/papers/10.3390/antiox13040494
The paper
Lin, E. T., Bae, Y., Birkett, R., Sharma, A. M., Zhang, R., Fisch, K. M., Funk, W., & Mestan, K. K. (2024). Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia. Antioxidants. https://doi.org/10.3390/antiox13040494

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.