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Cited by 11Medicinal Plant ResearchPhytochemistry and Biological ActivitiesPhytochemistry Medicinal Plant Applications

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Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

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Mahomoodally, Mohamad Fawzi, Sinan, Kouadio Ibrahime, Bene, Kouadio, Zengin, Gokhan, Orlando, Giustino, Menghini, Luigi, Veschi, Serena, Chiavaroli, Annalisa, Recinella, Lucia, Brunetti, Luigi, Leone, Sheila, Angelini, Paola, Hubka, Vit, Covino, Stefano, Venanzoni, Roberto, Picot-Allain, Marie Carene Nancy, De Lellis, Laura, Cama, Alessandro, Cziáky, Zoltán, Jekő, József, Ferrante, Claudio·2020·Antioxidants
DOI 10.3390/antiox9020128PMC PMC7070247
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Abstract

Bridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic effects of the extracts were evaluated against selected pathogen strains. Additionally, the anti-proliferative effects were studied on the liver cancer HepG2 cell line. Finally, the putative protective effects were assessed on isolated rat liver that was challenged with lipopolysaccharide (LPS). The results revealed the presence of 36 compounds in the ethyl acetate extract, 44 in the methanol extract, and 38 in the water extract. Overall, the methanol extract showed the highest antioxidant activity, particularly in LPS-stimulated rat liver. Additionally, this extract exerted the highest antimycotic effect on C. albicans, whereas the water extract showed a promising anti-proliferative effect on liver cancer HepG2 cells. The methanol extract was also the most active as enzyme inhibitor, against acetylcholinesterase and butyrylcholinesterase. The current study appraises the antioxidant and enzyme inhibition properties of B. speciosa methanol extract and showed that this specie could be a promising source of biologically active phytochemicals, with potential health uses.

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  • The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+.

    “The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+ [78–81].”

    From Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) (2020) · cites this paper as [80]

    The Results and Discussion section calls FRAP a common in vitro method for measuring reducing power and says it assesses reduction of ferric iron (Fe3+) to ferrous iron (Fe2+). It does not specifically describe the reaction as colorimetric or establish that the assay is reliable. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Metadata

Authors
Mahomoodally, M. F., Sinan, K. I., Bene, K., Zengin, G., Orlando, G., Menghini, L., Veschi, S., Chiavaroli, A., Recinella, L., Brunetti, L., Leone, S., Angelini, P., Hubka, V., Covino, S., Venanzoni, R., Picot-Allain, M. C. N., De Lellis, L., Cama, A., Cziáky, Z., Jekő, J., & Ferrante, C.
Affiliations
  • Duy Tan University (VN)
  • Selçuk University (TR)
  • Laboratoire de Botanique et Phytothérapie, Unité de Formation et de Recherche Sciences de la Nature, 02 BP 801 Abidjan 02, Université Nangui Abrogoua, 00225 Abidjan, Cote D’Ivoire
  • Department of Biology, Science Faculty, Selcuk Universtiy, Campus, 42130 Konya, Turkey
  • University of Chieti-Pescara (IT)
  • University of Perugia (IT)
  • Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic
  • University of Mauritius (MU)
  • Department of Pharmacy, “G. d’Annunzio” University Chieti-Pescara, 66100 Chieti, Italy
  • University of Nyíregyháza (HU)
Corresponding author
Orlando, Giustino
ORCID
Venue
Antioxidants
Publisher
MDPI AG
Published
2020-02-02
Volume
9
Issue
2
Pages
128
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox9020128
PMC
PMC7070247
OpenAlex
W3004396451
Cited by
11
References
0
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
Keywords
stem bark extract, phytochemical profiling, antioxidant activity, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, antibacterial activity, antifungal activity, Candida albicans, HepG2 cells, antiproliferative activity, liver cancer, hepatoprotection, lipopolysaccharide-induced liver injury, African traditional medicine, medicinal plants

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