Calcium Overload and Mitochondrial Metabolism
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Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to maintain optimal rates of ATP production, extreme levels of calcium overcoming the mitochondrial calcium retention capacity leads to loss of mitochondrial function. In moderate amounts, however, ATP synthesis rates are inhibited in a calcium-titratable manner. While the consequences of extreme calcium overload are well-known, the effects on mitochondrial function in the moderately loaded range remain enigmatic. These observations are associated with changes in the mitochondria ultrastructure and cristae network. The present mini review/perspective follows up on previous studies using well-established cryo–electron microscopy and poses an explanation for the observable depressed ATP synthesis rates in mitochondria during calcium-overloaded states. The results presented herein suggest that the inhibition of oxidative phosphorylation is not caused by a direct decoupling of energy metabolism via the opening of a calcium-sensitive, proteinaceous pore but rather a separate but related calcium-dependent phenomenon. Such inhibition during calcium-overloaded states points towards mitochondrial ultrastructural modifications, enzyme activity changes, or an interplay between both events.
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Ca2+ activates mitochondrial metabolism and stimulates ATP synthesis.
“Ca2+ activates mitochondrial metabolism and stimulates ATP synthesis”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [104]
Section 4 says calcium regulates TCA-cycle enzymes and links calcium homeostasis to ATP production. But the Introduction limits the beneficial effect to relatively low calcium levels; it says calcium overload impairs oxidative phosphorylation and inhibits ATP synthesis. The claim omits that condition and presents stimulation as an unqualified effect. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMitochondria buffer cytosolic calcium.
“mitochondria also buffer cytosolic calcium51,103,104.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [104]
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- Authors
- Walkon, L. L., Strubbe-Rivera, J. O., & Bazil, J. N.
- Affiliations
- Michigan State University (US)
- Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2022-12-17
- Volume
- 12
- Issue
- 12
- Pages
- 1891
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC9775684
- OpenAlex
- W4313236994
- Cited by
- 187
- References
- 95
- Citations by year
- 2026: 50 · 2025: 75 · 2024: 50 · 2023: 12
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (F31HL152623)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial calcium overload, mitochondrial calcium retention capacity, ATP synthesis inhibition, oxidative phosphorylation, mitochondrial ultrastructure, cryo-electron microscopy, mitochondrial function
- MeSH terms
- Adenosine Triphosphate, Calcium, Energy Metabolism, Mitochondria, Cryoelectron Microscopy
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