The DOI matches its Crossref record; 234 of the 234 references it cites were found in a registry or an index.
Selenium and Selenoproteins in Health
Open accessAbstract
Selenium is a trace mineral that is essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in the body in the form of selenoproteins, which are best known for their redox activity and anti-inflammatory properties. Selenium stimulates the activation of immune cells and is important for the activation of the immune system. Selenium is also essential for the maintenance of brain function. Selenium supplements can regulate lipid metabolism, cell apoptosis, and autophagy, and have displayed significant alleviating effects in most cardiovascular diseases. However, the effect of increased selenium intake on the risk of cancer remains unclear. Elevated serum selenium levels are associated with an increased risk of type 2 diabetes, and this relationship is complex and nonlinear. Selenium supplementation seems beneficial to some extent; however, existing studies have not fully explained the influence of selenium on various diseases. Further, more intervention trials are needed to verify the beneficial or harmful effects of selenium supplementation in various diseases.
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1 retracted
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RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature · doi:10.1038/nature24297 · Cited by 1,799
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Ingold, I., Berndt, C., Schmitt, S., Doll, S., Poschmann, G., Buday, K., Roveri, A., Peng, X., Porto Freitas, F., Seibt, T., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.048 · Cited by 1,656
Selenoproteins: Molecular Pathways and Physiological Roles
Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,409
Cited by
Qi, X., Wang, S., Fang, C., Jia, J., Lin, L., & Yuan, T. (2025) · Redox Biology · doi:10.1016/j.redox.2024.103470 · Cited by 271
Meng, Q., & Su, C.-H. (2024) · doi:10.20944/preprints202404.0770.v1 · Cited by 149
Metadata
- Authors
- Zhang, F., Li, X., & Wei, Y.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2023-05-08
- Volume
- 13
- Issue
- 5
- Pages
- 799
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W4378515660
- Cited by
- 361
- References
- 234
- FWCI
- 51.79
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.