Cited by 71Bacterial biofilms and quorum sensingAntimicrobial agents and applicationsInfection Control in Healthcare

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Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

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Verdial, Cláudia, Serrano, Isa, Tavares, Luís, Gil, Solange, Oliveira, Manuela·2023·Biomedicines

DOI 10.3390/biomedicines11041221PMC PMC10135826

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Abstract

Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple hospital- and community-acquired infections, both in human and veterinary medicine. P. aeruginosa persistence in clinical settings is worrisome and is a result of its remarkable flexibility and adaptability. This species exhibits several characteristics that allow it to thrive under different environmental conditions, including the ability to colonize inert materials such as medical equipment and hospital surfaces. P. aeruginosa presents several intrinsic mechanisms of defense that allow it to survive external aggressions, but it is also able to develop strategies and evolve into multiple phenotypes to persevere, which include antimicrobial-tolerant strains, persister cells, and biofilms. Currently, these emergent pathogenic strains are a worldwide problem and a major concern. Biocides are frequently used as a complementary/combination strategy to control the dissemination of P. aeruginosa-resistant strains; however, tolerance to commonly used biocides has also already been reported, representing an impediment to the effective elimination of this important pathogen from clinical settings. This review focuses on the characteristics of P. aeruginosa responsible for its persistence in hospital environments, including those associated with its antibiotic and biocide resistance ability.

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Figure 1 Schematic representation of P. aeruginosa secretion systems (T1SS to T6SS) and their functions (original).CC BY · PubMed Central

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Authors: Verdial, C., Serrano, I., Tavares, L., Gil, S., & Oliveira, M.
Affiliations: Gato Escondido—Veterinary Clinic, Av. Bombeiros Voluntários n°22B, 2950-209 Palmela, Portugal
University of Lisbon (PT)
Corresponding author: Serrano, Isa
ORCID: Verdial, Cláudia
Serrano, Isa
Tavares, Luís
Gil, Solange
Oliveira, Manuela
Venue: Biomedicines
Publisher: MDPI AG
Published: 2023-04-19
Volume: 11
Issue: 4
Pages: 1221
ISSN: 2227-9059 (ISSN-L)
DOI: 10.3390/biomedicines11041221
PMC: PMC10135826
OpenAlex: W4366588495
Cited by: 71
References: 208
Citations by year: 2026: 28 · 2025: 20 · 2024: 15 · 2023: 8
FWCI: 1.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomedicines (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords: Pseudomonas aeruginosa, antibiotic resistance, biocide resistance, biocide tolerance, persister cells, biofilm, antimicrobial tolerance, hospital environment, environmental persistence, nosocomial infections, opportunistic pathogens

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Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

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