The DOI matches its Crossref record; 205 of the 208 references it cites were found in a registry or an index.
Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment
Open accessAbstract
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple hospital- and community-acquired infections, both in human and veterinary medicine. P. aeruginosa persistence in clinical settings is worrisome and is a result of its remarkable flexibility and adaptability. This species exhibits several characteristics that allow it to thrive under different environmental conditions, including the ability to colonize inert materials such as medical equipment and hospital surfaces. P. aeruginosa presents several intrinsic mechanisms of defense that allow it to survive external aggressions, but it is also able to develop strategies and evolve into multiple phenotypes to persevere, which include antimicrobial-tolerant strains, persister cells, and biofilms. Currently, these emergent pathogenic strains are a worldwide problem and a major concern. Biocides are frequently used as a complementary/combination strategy to control the dissemination of P. aeruginosa-resistant strains; however, tolerance to commonly used biocides has also already been reported, representing an impediment to the effective elimination of this important pathogen from clinical settings. This review focuses on the characteristics of P. aeruginosa responsible for its persistence in hospital environments, including those associated with its antibiotic and biocide resistance ability.
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“Pseudomonas spp., on the other hand, typically take advantage of weakened immune systems and causes infections that can be acquired in hospitals or the community, affecting both humans and animals [73].”
From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [73]
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Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449
Liu, Y.-Y., Wang, Y., Walsh, T., Yi, L.-X., Zhang, R., Spencer, J., Doi, Y., Tian, G.-B., Dong, B.-L., Huang, X.-H., et al. (2016) · Lancet. Infectious Diseases (Print) · doi:10.1016/s1473-3099(15)00424-7 · Cited by 4,920
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S., Warrener, P., Hickey, M. J., Brinkman, F. S. L., HUFNAGLE, W. O., Kowalik, D., Mj, L., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,544
Molecular mechanisms of antibiotic resistance
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O., & Piddock, L. J. V. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3380 · Cited by 4,092
Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697
Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
Pang, Z., Raudonis, R., Glick, B. R., Lin, T., & Cheng, Z. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.013 · Cited by 2,520
How long do nosocomial pathogens persist on inanimate surfaces? A systematic review
Krämer, A., Schwebke, I., & Kampf, G. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-130 · Cited by 2,508
Lister, P., Wolter, D. J., & Hanson, N. D. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-09 · Cited by 1,901
Qin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., & Wu, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01056-1 · Cited by 1,679
Research works printed but not linked: 7
- Sousa, A. (2021). Avaliação In Vitro de Estratégicas Antimicrobianas Inovadoras Para Controlo de Otites Externas Por Pseudomonas Aeruginosa No Cão. [Master’s Thesis, Faculdade de Medicina Veterinária-Universidade de Lisboa].
- Petrov, 2013, Otitis Externa in Dogs: Microbiology and Antimicrobial Susceptibility, Rev. Med. Vet., 164, 18
- Jarvis, W.R. (2014). Bennett & Brachman’s Hospital Infections, Lippincott Williams & Wilkins.
- Quinn, P.J., Markey, B.K., Leonard, F.C., FitzPatrick, E.S., Fanning, S., and Hartigan, P.J. (2011). Veterinary Microbiology and Microbial Disease, Wiley-Blackwell.
- Greene, C.E. (2012). Infectious Diseases of the Dog and Cat, Elsevier Saunders.
- Caveney, L., Jones, B., and Ellis, K. (2016). Veterinary Infection Prevention and Control, John Wiley & Sons, Inc.
- Maillard, J. (2012). Russell, Hugo & Ayliffe’s, Wiley-Blackwell.
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Bereanu, A. S., Bereanu, R., Mohor, C. I., Vintilă, B. I., Codru, I. R., Olteanu, C., & Sava, M. (2024) · Antibiotics · doi:10.3390/antibiotics13050400 · Cited by 70
A systematic review of diabetic foot infections: pathogenesis, diagnosis, and management strategies
Maity, S., Leton, N., Nayak, N., Jha, A. K., Anand, N., Thompson, K., Boothe, D., Cromer, A., Garcia, Y., Al-Islam, A., et al. (2024) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2024.1393309 · Cited by 82
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Sendra, E., Fernández-Muñoz, A., Zamorano, L., Oliver, A., Horcajada, J. P., Juan, C., & Gómez-Zorrilla, S. (2024) · Infection · doi:10.1007/s15010-024-02313-x · Cited by 66
Metadata
- Authors
- Verdial, C., Serrano, I., Tavares, L., Gil, S., & Oliveira, M.
- Affiliations
- Gato Escondido—Veterinary Clinic, Av. Bombeiros Voluntários n°22B, 2950-209 Palmela, Portugal
- University of Lisbon (PT)
- Corresponding author
- Serrano, Isa
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2023-04-19
- Volume
- 11
- Issue
- 4
- Pages
- 1221
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC10135826
- OpenAlex
- W4366588495
- Cited by
- 71
- References
- 208
- Citations by year
- 2026: 28 · 2025: 20 · 2024: 15 · 2023: 8
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- Pseudomonas aeruginosa, antibiotic resistance, biocide resistance, biocide tolerance, persister cells, biofilm, antimicrobial tolerance, hospital environment, environmental persistence, nosocomial infections, opportunistic pathogens
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