Cited by 330Medicinal Plant ResearchPhytochemistry and Biological ActivitiesPhytochemicals and Antioxidant Activities

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In Vitro Anti-Inflammatory Properties of Selected Green Leafy Vegetables

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Gunathilake, K. D. P. P., Ranaweera, K. K. D. S., Rupasinghe, H. P. Vasantha·2018·Biomedicines

DOI 10.3390/biomedicines6040107PMC PMC6316011

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Abstract

The study investigated the anti-inflammatory activity of the hydro methanolic extract of six leafy vegetables, namely Cassia auriculata, Passiflora edulis, Sesbania grandiflora, Olax zeylanica, Gymnema lactiferum, and Centella asiatica. The anti-inflammatory activity of methanolic extracts of leafy vegetables was evaluated using four in vitro-based assays: hemolysis inhibition, proteinase inhibition, protein denaturation inhibition, and lipoxygenase inhibition. Results showed that the percent inhibition of hemolysis from these leaf extracts (25–100 µg/mL dry weight basis (DW)) was within the range from 5.4% to 14.9%, and the leaves of P. edulis and O. zeylanica showed a significantly higher (p < 0.05) inhibition levels. Percent inhibition of protein denaturation of these leafy types was within the range of 36.0–61.0%, and the leaf extract of C. auriculata has exhibited a significantly higher (p < 0.05) inhibition level. Proteinase inhibitory activity of these leaf extracts was within the range of 20.2–25.9%. The lipoxygenase inhibition was within the range of 3.7–36.0%, and the leaf extract of G. lactiferum showed an improved ability to inhibit lipoxygenase activity. In conclusion, results revealed that all the studied leaves possess anti-inflammatory properties at different levels, and this could be due to the differences in the composition and concentration of bioactive compounds.

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Figure 1 Effect of six green leafy vegetables on inhibition of hemolysis. Values represent means of triplicate readings. CAR—C. auriculata; GL—G. lactiferum; OZ—O. zeylanica; PE—P. edulis; CA—C. asiatica; SG—S. grandiflora. Data are presented as the means ± standard deviations of three replicate determinations.CC BY · PubMed Central

Figure 2 Effects of six green leafy vegetables on protein denaturation. Values represent means of triplicate readings. CAR—C. auriculata; GL—G. lactiferum; OZ—O. zeylanica; PE—P. edulis; CA—C. asiatica; SG—S. grandiflora. Data are presented as the means ± standard deviations of three replicate determinations.CC BY · PubMed Central

Figure 3 Proteinase inhibitory activity of green leafy vegetables. Values represent means of triplicate readings. CAR—C. auriculata; GL—G. lactiferum; OZ—O. zeylanica; PE—P. edulis; CA—C. asiatica; SG—S. grandiflora. Data are presented as the means ± standard deviations of three replicate determinations.CC BY · PubMed Central

Figure 4 Lipoxygenase inhibitory activity of green leafy vegetables. Values represent means of triplicate readings. CAR—C. auriculata; GL—G. lactiferum; OZ—O. zeylanica; PE—P. edulis; CA—C. asiatica; SG—S. grandiflora. Data are presented as the means ± standard deviations of three replicate determinations.CC BY · PubMed Central

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Authors: Gunathilake, K. D. P. P., Ranaweera, K. K. D. S., & Rupasinghe, H. P. V.
Affiliations: University of Sri Jayewardenepura (LK)
Dalhousie University (CA)
Corresponding author: Gunathilake, K. D. P. P.
ORCID: Gunathilake, K. D. P. P.
Ranaweera, K. K. D. S.
Rupasinghe, H. P. Vasantha
Venue: Biomedicines
Publisher: MDPI AG
Published: 2018-11-19
Volume: 6
Issue: 4
Pages: 107
ISSN: 2227-9059 (ISSN-L)
DOI: 10.3390/biomedicines6040107
PMC: PMC6316011
OpenAlex: W2901135781
Cited by: 330
References: 30
Citations by year: 2026: 45 · 2025: 67 · 2024: 50 · 2023: 59 · 2022: 61 · 2021: 28 · 2020: 14 · 2019: 5
FWCI: 10.40
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomedicines (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Wayamba University of Sri Lanka
National Science Foundation of Sri Lanka
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: anti-inflammatory activity, leafy vegetables, methanolic leaf extract, hemolysis inhibition, protease inhibition, protein denaturation inhibition, lipoxygenase inhibition, Passiflora edulis, Centella asiatica, Cassia auriculata, Sesbania grandiflora, bioactive compounds

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In Vitro Anti-Inflammatory Properties of Selected Green Leafy Vegetables

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