The Link between Chronic Stress and Accelerated Aging
Open accessAbstract
People exposed to chronic stress age rapidly. The telomeres in their cells of all types shorten faster. Inflammation is another important feature of stress that, along with aging, accounts for the phenomenon of inflammaging. In addition to aging itself, inflammaging can contribute to the development of several pathologies, including atherosclerosis, diabetes, hypertension, and others. Oxidative stress is one of the main mechanisms related to stress. Oxidative stress is caused by the over-production of reactive oxygen species (ROS) that can damage various tissues. The main source of ROS is mitochondria. Being suppressed by mitochondrial mutations, mitophagy can aggravate the situation. In this case, the aging-specific pro-inflammatory changes are amplified. It happens because of the inability of cells to maintain the normal state of mitochondria. Macrophages are the crucial element of the innate immunity associated with the chronic inflammation and, subsequently, with the inflammaging. In this review, we focus on the therapy approaches potentially reducing the deleterious effects of oxidative stress. These include stimulation of mitophagy, activation of mitochondrial uncoupling, induction of the expression of the telomerase catalytic component gene, and use of antioxidants. Any method reducing oxidative stress should improve post-traumatic stress disorder.
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Oxidative stress, caused by overproduction of reactive oxygen species, exacerbates tissue damage.
“Oxidative stress, caused by the overproduction of reactive oxygen species (ROS), further exacerbates tissue damage.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [74]
Mitochondria are the primary source of reactive oxygen species, and their dysfunction due to suppressed mitophagy amplifies pro-inflammatory changes specific to aging.
“Mitochondria are the primary source of ROS, and their dysfunction due to suppressed mitophagy amplifies pro-inflammatory changes specific to aging.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [74]
Chronic stress is a significant contributor to accelerated aging, primarily through mechanisms involving inflammation and oxidative stress.
“Chronic stress is a significant contributor to accelerated aging, primarily through mechanisms involving inflammation and oxidative stress.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [74]
Macrophages are central to chronic inflammation and inflammaging.
“Macrophages, key players in innate immunity, are central to chronic inflammation and inflammaging [74].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [74]
Inflammation, often termed "inflammaging", is a chronic, low-grade inflammatory state closely associated with aging and contributes to age-related pathologies including atherosclerosis, diabetes, and hypertension.
“Inflammation, often termed “inflammaging”, is a chronic, low-grade inflammatory state that is closely associated with aging. It contributes to various age-related pathologies, including atherosclerosis, diabetes, and hypertension.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [74]
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References 85 · Cited by 147
- Authors
- Yegorov, Y. E., Poznyak, A. V., Nikiforov, N. G., Sobenin, I. A., & Orekhov, A. N.
- Affiliations
- Engelhardt Institute of Molecular Biology (RU)
- Institute for Atherosclerosis Research (RU)
- Institute of Experimental Cardiology (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Corresponding author
- Poznyak, Anastasia V.
- Orekhov, Alexander N.
- ORCID
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2020-07-07
- Volume
- 8
- Issue
- 7
- Pages
- 198
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC7400286
- OpenAlex
- W3038994116
- Cited by
- 147
- References
- 85
- Citations by year
- 2026: 23 · 2025: 38 · 2024: 29 · 2023: 20 · 2022: 12 · 2021: 21 · 2020: 4
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Science Foundation (19-15-00297)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- chronic stress, accelerated aging, inflammaging, telomere shortening, oxidative stress, reactive oxygen species, mitochondrial dysfunction, mitophagy, mitochondrial uncoupling, telomerase, antioxidants, macrophages, post-traumatic stress disorder, atherosclerosis, diabetes mellitus, hypertension
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