Whitening Effects of a Novel Oral Care Gel with Biomimetic Hydroxyapatite: A 4-Week Observational Pilot Study
Open accessAbstract
The whitening effects of an oral care gel based on particulate microcrystalline hydroxyapatite, Ca5(PO4)3(OH), were tested in a 4-week observational pilot study. Patients were recruited from two dental practices in Germany. Participants were asked to complete a questionnaire regarding their personal perception of their tooth color and brightness as well as the level of dentin hypersensitivity at the baseline and after 4 weeks of twice daily use of an oral care gel with hydroxyapatite. Data of 25 patients with a mean age of 46 ± 16 years were analyzed. Various subjective whitening parameters showed a tendency to be improved after the 4-week use. Additionally, patients reported that symptoms of dentin hypersensitivity were significantly reduced (p < 0.05, 95% confidence interval (CI): (0.8; 2.4)), and the tooth surface was significantly smoother (p < 0.05, 95% CI: (0.54; 1.6)). In conclusion, microcrystalline hydroxyapatite is a promising whitening agent for oral care formulations and represents a biomimetic alternative to other whitening agents for daily dental care.
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The systematic search for in vivo evidence resulted in six studies ranging in quality from very low to moderate.
“The results of the systematic search for in vivo evidence resulted in six studies [42,49,50,51,52,53] ranging in quality from very low to moderate (Table 3).”
From Tooth Whitening with Hydroxyapatite: A Systematic Review (2023) · cites this paper as [50]
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- Authors
- Steinert, S., Kuchenbecker, J., Meyer, F., Simader, B., Zwanzig, K., & Enax, J.
- Affiliations
- Dental Practice, Mauerstraße 8, 33602 Bielefeld, Germany
- Dental Practice, Meinigstraße 29 A, 38667 Bad Harzburg, Germany
- Dr. August Wolff (Germany) (DE)
- Corresponding author
- Meyer, Frederic
- Enax, Joachim
- Venue
- Biomimetics
- Publisher
- MDPI AG
- Published
- 2020-11-24
- Volume
- 5
- Issue
- 4
- Pages
- 65
- ISSN
- 2313-7673 (ISSN-L)
- PMC
- PMC7768512
- OpenAlex
- W3108782024
- Cited by
- 13
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 7 · 2022: 2 · 2021: 2
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomimetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Dr. Kurt Wolff GmbH & Co. KG (Industrial grant)
- Topics
- Health Sciences › Dentistry › Orthodontics › Dental Erosion and Treatment
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- tooth bleaching, hydroxyapatite, dentin hypersensitivity
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