Cited by 135Glioma Diagnosis and TreatmentChronic Lymphocytic Leukemia ResearchPARP inhibition in cancer therapy

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Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

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Paolillo, Mayra, Boselli, Cinzia, Schinelli, Sergio·2018·Brain Sciences

DOI 10.3390/brainsci8010015PMC PMC5789346

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Abstract

Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with classical alkylating agents such as temozolomide offer little hope to escape a poor prognosis. For these reasons, enormous efforts are currently devoted to refine in vivo and in vitro models with the specific goal of finding new molecular aberrant pathways, suitable to be targeted by a variety of therapeutic approaches, including novel pharmaceutical formulations and immunotherapy strategies. In this review, we will first discuss current molecular classification based on genomic and transcriptomic criteria. Also, the state of the art in current clinical practice for glioblastoma therapy in the light of the recent molecular classification, together with ongoing phases II and III clinical trials, will be described. Finally, new pharmaceutical formulations such as nanoparticles and viral vectors, together with new strategies entailing the use of monoclonal antibodies, vaccines and immunotherapy agents, such as checkpoint inhibitors, will also be discussed.

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Authors: Paolillo, M., Boselli, C., & Schinelli, S.
Affiliations: University of Pavia (IT)
Corresponding author: Paolillo, Mayra
ORCID: Paolillo, Mayra
Boselli, Cinzia
Schinelli, Sergio
Venue: Brain Sciences
Publisher: MDPI AG
Published: 2018-01-16
Volume: 8
Issue: 1
Pages: 15
ISSN: 2076-3425 (ISSN-L)
DOI: 10.3390/brainsci8010015
PMC: PMC5789346
OpenAlex: W2788894351
Cited by: 135
References: 68
Citations by year: 2026: 7 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 17 · 2021: 24 · 2020: 25 · 2019: 27 · 2018: 12
FWCI: 3.15
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Brain Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Health Sciences › Medicine › Hematology › Chronic Lymphocytic Leukemia Research
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: glioblastoma, molecular classification, temozolomide, alkylating agents, combination therapy, clinical trials, nanoparticles, viral vectors, monoclonal antibodies, cancer vaccines, immunotherapy, immune checkpoint inhibitors

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Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

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