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Cited by 17Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsSexual Differentiation and Disorders

Endocrine disruptors induced distinct expression of thyroid and estrogen receptors in rat versus mouse primary cerebellar cell cultures

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Jocsak, Gergely, Ioja, Eniko, Kiss, David Sandor, Toth, Istvan, Barany, Zoltan, Bartha, Tibor, Frenyo, Laszlo V., Zsarnovszky, Attila·2019·Brain Sciences
DOI 10.3390/brainsci9120359PMC PMC6955918
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Abstract

The endocrine system of animals consists of fine-tuned self-regulating mechanisms that maintain the hormonal and neuronal milieu during tissue development. This complex system can be influenced by endocrine disruptors (ED)—substances that can alter the hormonal regulation even in small concentrations. By now, thousands of substances—either synthesized by the plastic, cosmetic, agricultural, or medical industry or occurring naturally in plants or in polluted groundwater—can act as EDs. Their identification and testing has been a hard-to-solve problem; Recent indications that the ED effects may be species-specific just further complicated the determination of biological ED effects. Here we compare the effects of bisphenol-A, zearalenone, and arsenic (well-known EDs) exerted on mouse and rat neural cell cultures by measuring the differences of the ED-affected neural estrogen- and thyroid receptors. EDs alters the receptor expression in a species-like manner detectable in the magnitude as well as in the nature of biological responses. It is concluded that the interspecies differences (or species specificity) in ED effects should be considered in the future testing of ED effects.

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  • Zearalenone (ZEN) can directly interfere with hormonal signaling pathways as a phytoestrogen due to its structural similarity to 17-β-estradiol.

    “Among them, zearalenone (ZEN) plays a special role, as it can directly interfere with hormonal signaling pathways as a phytoestrogen due to its structural similarity to 17-β-estradiol (Jocsak et al., 2019; Kiss et al., 2018).”

    From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Jocsak et al., 2019

    The Introduction calls ZEN a mycoestrogen that acts on estrogen receptors, and Discussion §4.1 says its E2-like structure lets it directly affect cells. The paper identifies ZEN as a fungal metabolite, however, rather than a phytoestrogen; that classification is not supported. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Jocsak, G., Ioja, E., Kiss, D. S., Toth, I., Barany, Z., Bartha, T., Frenyo, L. V., & Zsarnovszky, A.
Affiliations
  • Department of Physiology and Biochemistry, University of Veterinary Medicine, 1078 Budapest, Hungary
  • Gedeon Richter Plc., Gyömrői út 19–21, 1103 Budapest, Hungary
  • University of Veterinary Medicine (HU)
  • Magyar Agrár- és Élettudományi Egyetem (HU)
ORCID
Kiss, David Sandor
Venue
Brain Sciences
Publisher
MDPI AG
Published
2019-12-05
Volume
9
Issue
12
Pages
359
ISSN
2076-3425 (ISSN-L)
DOI
10.3390/brainsci9120359
PMC
PMC6955918
OpenAlex
W2993181801
Cited by
17
References
2
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 1 · 2021: 5 · 2020: 1 · 2018: 1
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Hungarian Scientific Research Fund (OTKA K-115613)
  • Hungarian Ministry of Human Resources (NKB 69P00RH02, IK-UK-2018 49P13AIO3)
  • European Social Fund (EFOP-3.6.3-VEKOP-16-2017-00008)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
endocrine disruptors, thyroid hormone receptor, estrogen receptor, cerebellar cells, species specificity, bisphenol A, zearalenone, arsenic, receptor expression, neuroendocrine regulation

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