The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer
Open accessAbstract
A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative glycolysis has long been considered as one of the major metabolic pathways that allows energy production and provides intermediates for the anabolic growth of cancer cells. Although such a vision has been crucial for the development of clinical imaging modalities, it has become now evident that in contrast to prior beliefs, mitochondria play a key role in tumorigenesis. Recent findings demonstrated that a full genetic disruption of the Warburg effect of aggressive cancers does not suppress but instead reduces tumor growth. Tumor growth then relies exclusively on functional mitochondria. Besides having fundamental bioenergetic functions, mitochondrial metabolism indeed provides appropriate building blocks for tumor anabolism, controls redox balance, and coordinates cell death. Hence, mitochondria represent promising targets for the development of novel anti-cancer agents. Here, after revisiting the long-standing Warburg effect from a historic and dynamic perspective, we review the role of mitochondria in cancer with particular attention to the cancer cell-intrinsic/extrinsic mechanisms through which mitochondria influence all steps of tumorigenesis, and briefly discuss the therapeutic potential of targeting mitochondrial metabolism for cancer therapy.
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Cites
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
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Cited by
Revisiting the Warburg effect: historical dogma versus current understanding
Vaupel, P., & Multhoff, G. (2021) · The Journal of Physiology · doi:10.1113/jp278810 · Cited by 830
Mitochondria: It is all about energy
Casanova, A., Wevers, A., Navarro-Ledesma, S., & Pruimboom, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1114231 · Cited by 303
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 267
The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities
Cordani, M., Michetti, F., Zarrabi, A., Zarepour, A., Rumio, C., Strippoli, R., & Marcucci, F. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101076 · Cited by 40
Metadata
- Authors
- Cassim, S., Vučetić, M., Ždralević, M., & Pouyssegur, J.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-04-30
- Volume
- 12
- Issue
- 5
- Pages
- 1119
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W3022146681
- Cited by
- 175
- References
- 57
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cassim, S., Vučetić, M., Ždralević, M., & Pouyssegur, J. (2020). Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer. Cancers. https://doi.org/10.3390/cancers12051119
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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