Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer
Open accessAbstract
Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric patients, but they also cause some toxic effects: ototoxicity, myelosuppression, nephrotoxicity, and neurotoxicity. Hearing damage is one of the main toxic effects of platinum compounds, and it derives from the degeneration of hair cells of the ear, which, not having self-renewal capacity, cannot reconstitute themselves. Hearing loss from platinum exposure is typically bilateral, sensorineural, and permanent, and it is caused by the same mechanisms with which platinum acts on neoplastic cells. According to available data from the literature, the optimal timing for the audiological test during and after treatment with platinum compounds is not well defined. Moreover, no substances capable of preventing the onset of hearing loss have been identified.
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In addition to cumulative cisplatin dose, peak drug exposure, young age at treatment, co-administration of other ototoxic drugs and others are well-defined risk factors for more severe auditory damage.
“In addition to the cumulative cisplatin dose, peak drug exposure, young age at treatment, co-administration of other ototoxic drugs and others are well-defined risk factors for more severe auditory damage 167,168,169 .”
From Osteosarcoma (2022) · cites this paper as [169]
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Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
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Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity
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Cisplatin Induces Apoptosis in Mouse Neonatal Testes Organ Culture
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Gum Acacia attenuates cisplatin toxic effect spermatogenesis dysfunction and infertility in rats
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Systemic exposure to cisplatin and paclitaxel after intraperitoneal chemotherapy in ovarian cancer
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Miaskowski, C. A., Mastick, J., Paul, S. M., Wallhagen, M. L., Abrams, G., & Levine, J. D. (2022) · Journal of Cancer Survivorship · doi:10.1007/s11764-022-01301-0 · Cited by 10 · see citing works
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Hendriyanto, D., Rahman, S., Tofrizal, T., & Elliyanti, A. (2025) · Journal of Research in Pharmacy · doi:10.12991/jrespharm.1797969
Ma, Y., Han, Z., Feng, Y., Kong, X., Wang, Y., Li, L., Yang, W., Yang, K., Zhang, T., Li, Z., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118618
de Jager, K. E., Streefkerk, N., Hoetink, A. E., van Tinteren, H., van Grotel, M., & van den Heuvel‐Eibrink, M. M. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1769234
Chawla, A., Carter, S., Wood, A., Staffieri, S., Dodgshun, A. J., Eisenstat, D. D., & Sullivan, M. J. (2026) · medRxiv · doi:10.64898/2026.05.21.26353442
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Orhan, M. F., Tiryaki, Ö., Kudubeş, A. A., Zengin, H., & DELİBAŞ, K. (2026) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000003270
Omar, B., AlAli, A., Qrareya, H., Abdallah, L., Zarrouk, A., & Warad, I. (2026) · Results in Chemistry · doi:10.1016/j.rechem.2026.103992
- Authors
- Romano, A., Capozza, M. A., Mastrangelo, S., Maurizi, P., Triarico, S., Rolesi, R., Attinà, G., Fetoni, A. R., & Ruggiero, A.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Ruggiero, Antonio
- ORCID
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-05-17
- Volume
- 12
- Issue
- 5
- Pages
- 1266
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC7281210
- OpenAlex
- W3025135956
- Cited by
- 65
- References
- 94
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 15 · 2021: 9 · 2020: 2
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- cisplatin, carboplatin, oxaliplatin, pediatric cancer chemotherapy, sensorineural hearing loss, hair cell degeneration, audiological monitoring, ototoxicity prevention, myelosuppression, nephrotoxicity, neurotoxicity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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