The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Molecular Biology of Osteosarcoma
Open accessAbstract
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents and the third most frequent in adults. Many inherited germline mutations are responsible for syndromes that predispose to osteosarcomas including Li Fraumeni syndrome, retinoblastoma syndrome, Werner syndrome, Bloom syndrome or Diamond–Blackfan anemia. TP53 is the most frequently altered gene in osteosarcoma. Among other genes mutated in more than 10% of OS cases, c-Myc plays a role in OS development and promotes cell invasion by activating MEK–ERK pathways. Several genomic studies showed frequent alterations in the RB gene in pediatric OS patients. Osteosarcoma driver mutations have been reported in NOTCH1, FOS, NF2, WIF1, BRCA2, APC, PTCH1 and PRKAR1A genes. Some miRNAs such as miR-21, -34a, -143, -148a, -195a, -199a-3p and -382 regulate the pathogenic activity of MAPK and PI3K/Akt-signaling pathways in osteosarcoma. CD133+ osteosarcoma cells have been shown to exhibit stem-like gene expression and can be tumor-initiating cells and play a role in metastasis and development of drug resistance. Although currently osteosarcoma treatment is based on adriamycin chemoregimens and surgery, there are several potential targeted therapies in development. First of all, activity and safety of cabozantinib in osteosarcoma were studied, as well as sorafenib and pazopanib. Finally, novel bifunctional molecules, of potential imaging and osteosarcoma targeting applications may be used in the future.
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Cites
1 retracted
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
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Mutational Processes Molding the Genomes of 21 Breast Cancers
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The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
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Cited by
Advances on immunotherapy for osteosarcoma
Yu, S., & Yao, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02105-9 · Cited by 270
“It originates from mesenchymal stem cells, characterized by osteoid product [2].”
BackgroundBientinesi, E., Lulli, M., Becatti, M., Ristori, S., Margheri, F., & Monti, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111689 · Cited by 61
Tharakan, S., Raja, I., Pietraru, A., Sarecha, E., Gresita, A., Petcu, E., Ilyas, A., & Hadjiargyrou, M. (2023) · Gels · doi:10.3390/gels9040274 · Cited by 18
Liu, S., Wu, B., Li, X., Zhao, L., Wu, W., & Ai, S. (2021) · Journal of Oncology · doi:10.1155/2021/2719172 · Cited by 15
Metadata
- Authors
- Czarnecka, A. M., Synoradzki, K., Firlej, W., Bartnik, E., Sobczuk, P., Fiedorowicz, M., Grieb, P., & Rutkowski, P.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-07-31
- Volume
- 12
- Issue
- 8
- Pages
- 2130
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W3046780965
- Cited by
- 336
- References
- 175
- FWCI
- 27.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Molecular Biology of Osteosarcoma. https://app.cochat.ai/papers/10.3390/cancers12082130
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- Czarnecka, A. M., Synoradzki, K., Firlej, W., Bartnik, E., Sobczuk, P., Fiedorowicz, M., Grieb, P., & Rutkowski, P. (2020). Molecular Biology of Osteosarcoma. Cancers. https://doi.org/10.3390/cancers12082130
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
