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Advanced Tumor Imaging Approaches in Human Tumors
Abstract
The management of cancer has always relied heavily on the imaging modalities used to detect and monitor it. While many of these modalities have been around for decades, the technology surrounding them is always improving, and much has been discovered in recent years about the nature of tumors because of this. There have been several areas that have aided those discoveries. The use of artificial intelligence has already helped immensely in the quality of images taken but has not yet been widely implemented in clinical settings. Molecular imaging has proven to be useful in diagnosing different types of cancers based on the specificity of the probes/contrast agents used. Intravital imaging has already uncovered new information regarding the heterogeneity of the tumor vasculature. These three areas have provided a lot of useful information for the diagnosis and treatment of cancer, but further research and development in human trials is necessary to allow these techniques to fully utilize the information obtained thus far.
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“Interestingly, what appear to be barriers can also be exploited as triggers: local acidity and enzymatic activity can induce size shrinkage and charge reversal; hypoxia and redox gradients can open transcytotic pathways and expose latent ligands.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [9]
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“Through such mechanisms, these cues can be harnessed to invert biological filters and propel nanomedicines beyond perivascular regions into tumor cores [9].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [9]
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“Interestingly, what appear to be barriers can also be exploited as triggers: local acidity and enzymatic activity can induce size shrinkage and charge reversal; hypoxia and redox gradients can open transcytotic pathways and expose latent ligands.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [9]
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Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- Nussbaum, S., Shoukry, M., Ashary, M. A., Kasbi, A. A., Baksh, M., & Gabriel, E.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2022-03-18
- Volume
- 14
- Issue
- 6
- Pages
- 1549
- ISSN
- 2072-6694
- PMC
- PMC8945965
- Cited by
- 18
- References
- 1
- Language
- en
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