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Cited by 7Nutrition and Health in AgingClinical Nutrition and GastroenterologyInflammatory Biomarkers in Disease Prognosis

Assessment of Functional and Nutritional Status and Skeletal Muscle Mass for the Prognosis of Critically Ill Solid Cancer Patients

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Vigneron, Clara, Laousy, Othmane, Chassagnon, Guillaume, Vakalopoulou, Maria, Charpentier, Julien, Alexandre, Jérôme, Jamme, Matthieu, Pène, Frédéric·2022·Cancers
DOI 10.3390/cancers14235870PMC PMC9737490
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Abstract

Simple and accessible prognostic factors are paramount for solid cancer patients experiencing life-threatening complications. The aim of this study is to appraise the impact of functional and nutritional status and skeletal muscle mass in this population. We conducted a retrospective (2007–2020) single-center study by enrolling adult patients with solid cancers requiring unplanned ICU admission. Performance status, body weight, and albumin level were collected at ICU admission and over six months. Skeletal muscle mass was assessed at ICU admission by measuring muscle areas normalized by height (SMI). Four-hundred and sixty-two patients were analyzed, mainly with gastro-intestinal (34.8%) and lung (29.9%) neoplasms. Moreover, 92.8% of men and 67.3% of women were deemed cachectic. In the multivariate analysis, performance status at ICU admission (CSH 1.74 [1.27–2.39], p < 0.001) and the six month increase in albumin level (CSH 0.38 [0.16–0.87], p = 0.02) were independent predictors of ICU mortality. In the subgroup of mechanically ventilated patients, the psoas SMI was independently associated with ICU mortality (CSH 0.82 [0.67–0.98], p = 0.04). Among the 368 ICU-survivors, the performance status at ICU admission (CSH 1.34 [1.14–1.59], p < 0.001) and the six-month weight loss (CSH 1.33 [1.17–2.99], p = 0.01) were associated with a one-year mortality rate. Most cancer patients displayed cachexia at ICU admission. Time courses of nutritional parameters may aid the prediction of short- and long-term outcomes.

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  • Functional status on admission to intensive care units is an independent predictor of mortality, especially in cancer patients.

    “It has been reported that functional status on admission to intensive care units (ICU) is an independent predictor of mortality, especially in cancer patients [105,106].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [105]

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Authors
Vigneron, C., Laousy, O., Chassagnon, G., Vakalopoulou, M., Charpentier, J., Alexandre, J., Jamme, M., & Pène, F.
Affiliations
  • Université Paris Cité (FR)
  • Université Paris-Saclay (FR)
  • Université de Versailles Saint-Quentin-en-Yvelines (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Pène, Frédéric
ORCID
Venue
Cancers
Publisher
MDPI AG
Published
2022-11-29
Volume
14
Issue
23
Pages
5870
ISSN
2072-6694 (ISSN-L)
DOI
10.3390/cancers14235870
PMC
PMC9737490
OpenAlex
W4310191250
Cited by
7
References
1
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Société de Réanimation de Langue Française
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
solid tumors, critically ill cancer patients, skeletal muscle mass, skeletal muscle index, performance status, nutritional status, cachexia, albumin, ICU mortality, long-term mortality, weight loss, mechanical ventilation, prognostic factors

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