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Cited by 25Protein Kinase Regulation and GTPase SignalingProtein Tyrosine PhosphatasesCancer Mechanisms and Therapy

The Role of GAB1 in Cancer

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Pérez-Baena, Manuel Jesús, Cordero-Pérez, Francisco Josué, Pérez-Losada, Jesús, Holgado-Madruga, Marina·2023·Cancers
DOI 10.3390/cancers15164179PMC PMC10453317
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Abstract

GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, GAB1 transitions from the cytoplasm to the membrane where it is phosphorylated by a range of kinases. This event recruits SH2 domain-containing proteins like SHP2, PI3K’s p85 subunit, CRK, and others, thereby activating distinct signaling pathways, including MAPK, PI3K/AKT, and JNK. GAB1-deficient embryos succumb in utero, presenting with developmental abnormalities in the heart, placenta, liver, skin, limb, and diaphragm myocytes. Oncogenic mutations have been identified in the context of cancer. GAB1 expression levels are disrupted in various tumors, and elevated levels in patients often portend a worse prognosis in multiple cancer types. This review focuses on GAB1’s influence on cellular transformation particularly in proliferation, evasion of apoptosis, metastasis, and angiogenesis—each of these processes being a cancer hallmark. GAB1 also modulates the resistance/sensitivity to antitumor therapies, making it a promising target for future anticancer strategies.

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  • GAB1 is a direct target of miR-21 and is important for tumor angiogenesis and metastasis.

    “GAB1 a direct target of miR-21, is an important gene for tumor angiogenesis and metastasis, it is also involved in diverse biological processes such as cellular proliferation and differentiation, survival, angiogenesis, and inflammation.”

    From miR-21 as a diagnostic and prognostic biomarker in glioma: tissue and serum expression analysis in a Pakistani cohort (2026) · cites this paper as [43]

    Section 3, “Role of GAB1 in Cancer” (page not provided), says GAB1 is involved in biological processes fundamental to tumor angiogenesis and metastasis; sections 3.2 and 3.3 give examples of those roles. The passages do not identify GAB1 as a direct target of miR-21, so that part of the attributed claim is unsupported. (LLM, conf=0.88)

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  1. [1]White M.F. Yenush L. The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action Curr. Top. Microbiol. Immunol. 1998 228 179 208 10.1007/978-3-642-80481-6_8 9401207 · DOI
  2. [2]Hibi M. Hirano T. Gab-Family Adapter Molecules in Signal Transduction of Cytokine and Growth Factor Receptors, and T and B Cell Antigen Receptors Leuk. Lymphoma 2000 37 299 307 10.3109/10428190009089430 10752981 · DOI
  3. [3]Huyer G. Alexander D.R. Immune Signalling: SHP-2 Docks at Multiple Ports Curr. Biol. 1999 9 129 132 10.1016/S0960-9822(99)80080-3 10074424 · DOI
  4. [4]Gu H. Neel B.G. The “Gab” in Signal Transduction Trends Cell Biol. 2003 13 122 130 10.1016/S0962-8924(03)00002-3 12628344 · DOI
  5. [5]Holgado-Madruga M. Emlet D.R. Moscatello D.K. Godwin A.K. Wong A.J. A Grb2-Associated Docking Protein in EGF- and Insulin-Receptor Signalling Nature 1996 379 560 564 10.1038/379560a0 8596638 · DOI
  6. [6]Gu H. Pratt J.C. Burakoff S.J. Neel B.G. Cloning of P97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation Mol. Cell 1998 2 729 740 10.1016/S1097-2765(00)80288-9 9885561 · DOI
  7. [7]Wolf I. Jenkins B.J. Liu Y. Seiffert M. Custodio J.M. Young P. Rohrschneider L.R. Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation Mol. Cell. Biol. 2002 22 231 244 10.1128/MCB.22.1.231-244.2002 11739737 PMC134230 · DOI
  8. [8]Raabe T. Riesgo-Escovar J. Liu X. Bausenwein B.S. Deak P. Maröy P. Hafen E. DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila Cell 1996 85 911 920 10.1016/S0092-8674(00)81274-X 8681385 · DOI
  9. [9]Herbst R. Carroll P.M. Allard J.D. Schilling J. Raabe T. Simon M.A. Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling Cell 1996 85 899 909 10.1016/S0092-8674(00)81273-8 8681384 · DOI
  10. [10]Schutzman J.L. Borland C.Z. Newman J.C. Robinson M.K. Kokel M. Stern M.J. The Caenorhabditis Elegans EGL-15 Signaling Pathway Implicates a DOS-like Multisubstrate Adaptor Protein in Fibroblast Growth Factor Signal Transduction Mol. Cell. Biol. 2001 21 8104 8116 10.1128/MCB.21.23.8104-8116.2001 11689700 PMC99976 · DOI
  11. [11]Liu Y. Rohrschneider L.R. The Gift of Gab FEBS Lett. 2002 515 1 7 10.1016/S0014-5793(02)02425-0 11943184 · DOI
  12. [12]Yamada K. Nishida K. Hibi M. Hirano T. Matsuda Y. Comparative FISH Mapping of GAB1 and Gab2 Genes in Human, Mouse and Rat Cytogenet. Cell Genet. 2001 94 39 42 10.1159/000048780 11701952 · DOI
  13. [13]Yasui T. Masaki T. Arita Y. Ishibashi T. Inagaki T. Okazawa M. Oka T. Shioyama W. Yamauchi-Takihara K. Komuro I. Molecular Characterization of Striated Muscle-Specific GAB1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes PLoS ONE 2016 11 e0166710 10.1371/journal.pone.0166710 27861634 PMC5115770 · DOI
  14. [14]Nguyen L. Holgado-Madruga M. Maroun C. Fixman E.D. Kamikura D. Fournier T. Charest A. Tremblay M.L. Wong A.J. Park M. Association of the Multisubstrate Docking Protein GAB1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356 J. Biol. Chem. 1997 272 20811 20819 10.1074/jbc.272.33.20811 9252406 · DOI
  15. [15]Osawa M. Itoh S. Ohta S. Huang Q. Berk B.C. Marmarosh N.-L. Che W. Ding B. Yan C. Abe J. ERK1/2 Associates with the c-Met-Binding Domain of Growth Factor Receptor-Bound Protein 2 (Grb2)-Associated Binder-1 (GAB1): Role in ERK1/2 and Early Growth Response Factor-1 (Egr-1) Nuclear Accumulation J. Biol. Chem. 2004 279 29691 29699 10.1074/jbc.M309371200 15078886 · DOI
  16. [16]Itoh M. Yoshida Y. Nishida K. Narimatsu M. Hibi M. Hirano T. Role of GAB1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation Mol. Cell. Biol. 2000 20 3695 3704 10.1128/MCB.20.10.3695-3704.2000 10779359 PMC85666 · DOI
  17. [17]Sachs M. Brohmann H. Zechner D. Müller T. Hülsken J. Walther I. Schaeper U. Birchmeier C. Birchmeier W. Essential Role of GAB1 for Signaling by the C-Met Receptor in Vivo J. Cell Biol. 2000 150 1375 1384 10.1083/jcb.150.6.1375 10995442 PMC2150711 · DOI
  18. [18]Lamorte L. Kamikura D.M. Park M. A Switch from P130Cas/Crk to GAB1/Crk Signaling Correlates with Anchorage Independent Growth and JNK Activation in Cells Transformed by the Met Receptor Oncoprotein Oncogene 2000 19 5973 5981 10.1038/sj.onc.1203977 11146548 · DOI
  19. [19]Chan P.-C. Chen Y.-L. Cheng C.-H. Yu K.-C. Cary L.A. Shu K.-H. Ho W.L. Chen H.-C. Src Phosphorylates Grb2-Associated Binder 1 upon Hepatocyte Growth Factor Stimulation J. Biol. Chem. 2003 278 44075 44082 10.1074/jbc.M305745200 12941962 · DOI
  20. [20]Podar K. Mostoslavsky G. Sattler M. Tai Y.-T. Hayashi T. Catley L.P. Hideshima T. Mulligan R.C. Chauhan D. Anderson K.C. Critical Role for Hematopoietic Cell Kinase (Hck)-Mediated Phosphorylation of GAB1 and Gab2 Docking Proteins in Interleukin 6-Induced Proliferation and Survival of Multiple Myeloma Cells J. Biol. Chem. 2004 279 21658 21665 10.1074/jbc.M305783200 15010462 · DOI
  21. [21]Fan G. Zhang S. Gao Y. Greer P.A. Tonks N.K. HGF-Independent Regulation of MET and GAB1 by Nonreceptor Tyrosine Kinase FER Potentiates Metastasis in Ovarian Cancer Genes Dev. 2016 30 1542 1557 10.1101/gad.284166.116 27401557 PMC4949327 · DOI
  22. [22]Sun Y. Yuan J. Liu H. Shi Z. Baker K. Vuori K. Wu J. Feng G.-S. Role of GAB1 in UV-Induced c-Jun NH2-Terminal Kinase Activation and Cell Apoptosis Mol. Cell. Biol. 2004 24 1531 1539 10.1128/MCB.24.4.1531-1539.2004 14749370 PMC344197 · DOI
  23. [23]Jin Z.-G. Wong C. Wu J. Berk B.C. Flow Shear Stress Stimulates GAB1 Tyrosine Phosphorylation to Mediate Protein Kinase B and Endothelial Nitric-Oxide Synthase Activation in Endothelial Cells J. Biol. Chem. 2005 280 12305 12309 10.1074/jbc.M500294200 15665327 PMC4228934 · DOI
  24. [24]Holgado-Madruga M. Wong A.J. GAB1 Is an Integrator of Cell Death versus Cell Survival Signals in Oxidative Stress Mol. Cell. Biol. 2003 23 4471 4484 10.1128/MCB.23.13.4471-4484.2003 12808090 PMC164844 · DOI
  25. [25]Dixit M. Loot A.E. Mohamed A. Fisslthaler B. Boulanger C.M. Ceacareanu B. Hassid A. Busse R. Fleming I. GAB1, SHP2, and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress Circ. Res. 2005 97 1236 1244 10.1161/01.RES.0000195611.59811.ab 16284184 · DOI
  26. [26]Weidner K.M. Di Cesare S. Sachs M. Brinkmann V. Behrens J. Birchmeier W. Interaction between GAB1 and the C-Met Receptor Tyrosine Kinase Is Responsible for Epithelial Morphogenesis Nature 1996 384 173 176 10.1038/384173a0 8906793 · DOI
  27. [27]Schaeper U. Vogel R. Chmielowiec J. Huelsken J. Rosario M. Birchmeier W. Distinct Requirements for GAB1 in Met and EGF Receptor Signaling in Vivo Proc. Natl. Acad. Sci. USA 2007 104 15376 15381 10.1073/pnas.0702555104 17881575 PMC2000540 · DOI
  28. [28]Lock L.S. Frigault M.M. Saucier C. Park M. Grb2-Independent Recruitment of GAB1 Requires the C-Terminal Lobe and Structural Integrity of the Met Receptor Kinase Domain J. Biol. Chem. 2003 278 30083 30090 10.1074/jbc.M302675200 12766170 · DOI
  29. [29]Saucier C. Papavasiliou V. Palazzo A. Naujokas M.A. Kremer R. Park M. Use of Signal Specific Receptor Tyrosine Kinase Oncoproteins Reveals That Pathways Downstream from Grb2 or Shc Are Sufficient for Cell Transformation and Metastasis Oncogene 2002 21 1800 1811 10.1038/sj.onc.1205261 11896612 · DOI
  30. [30]Bard-Chapeau E.A. Yuan J. Droin N. Long S. Zhang E.E. Nguyen T.V. Feng G.-S. Concerted Functions of GAB1 and Shp2 in Liver Regeneration and Hepatoprotection Mol. Cell. Biol. 2006 26 4664 4674 10.1128/MCB.02253-05 16738330 PMC1489129 · DOI
  31. [31]Lock L.S. Royal I. Naujokas M.A. Park M. Identification of an Atypical Grb2 Carboxyl-Terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-Dependent and -Independent Recruitment of GAB1 to Receptor Tyrosine Kinases J. Biol. Chem. 2000 275 31536 31545 10.1074/jbc.M003597200 10913131 · DOI
  32. [32]Holgado-Madruga M. Moscatello D.K. Emlet D.R. Dieterich R. Wong A.J. Grb2-Associated Binder-1 Mediates Phosphatidylinositol 3-Kinase Activation and the Promotion of Cell Survival by Nerve Growth Factor Proc. Natl. Acad. Sci. USA 1997 94 12419 12424 10.1073/pnas.94.23.12419 9356464 PMC24976 · DOI
  33. [33]Rodrigues G.A. Falasca M. Zhang Z. Ong S.H. Schlessinger J. A Novel Positive Feedback Loop Mediated by the Docking Protein GAB1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling Mol. Cell. Biol. 2000 20 1448 1459 10.1128/MCB.20.4.1448-1459.2000 10648629 PMC85307 · DOI
  34. [34]Yart A. Laffargue M. Mayeux P. Chretien S. Peres C. Tonks N. Roche S. Payrastre B. Chap H. Raynal P. A Critical Role for Phosphoinositide 3-Kinase Upstream of GAB1 and SHP2 in the Activation of Ras and Mitogen-Activated Protein Kinases by Epidermal Growth Factor J. Biol. Chem. 2001 276 8856 8864 10.1074/jbc.M006966200 11134009 · DOI
  35. [35]Laffargue M. Raynal P. Yart A. Peres C. Wetzker R. Roche S. Payrastre B. Chap H. An Epidermal Growth Factor Receptor/GAB1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid J. Biol. Chem. 1999 274 32835 32841 10.1074/jbc.274.46.32835 10551845 · DOI
  36. [36]Ong S.H. Hadari Y.R. Gotoh N. Guy G.R. Schlessinger J. Lax I. Stimulation of Phosphatidylinositol 3-Kinase by Fibroblast Growth Factor Receptors Is Mediated by Coordinated Recruitment of Multiple Docking Proteins Proc. Natl. Acad. Sci. USA 2001 98 6074 6079 10.1073/pnas.111114298 11353842 PMC33424 · DOI
  37. [37]Sugimoto Y. Whitman M. Cantley L.C. Erikson R.L. Evidence That the Rous Sarcoma Virus Transforming Gene Product Phosphorylates Phosphatidylinositol and Diacylglycerol Proc. Natl. Acad. Sci. USA 1984 81 2117 2121 10.1073/pnas.81.7.2117 6326105 PMC345448 · DOI
  38. [38]Fruman D.A. Chiu H. Hopkins B.D. Bagrodia S. Cantley L.C. Abraham R.T. The PI3K Pathway in Human Disease Cell 2017 170 605 635 10.1016/j.cell.2017.07.029 28802037 PMC5726441 · DOI · Paper page
  39. [39]Whitman M. Downes C.P. Keeler M. Keller T. Cantley L. Type I Phosphatidylinositol Kinase Makes a Novel Inositol Phospholipid, Phosphatidylinositol-3-Phosphate Nature 1988 332 644 646 10.1038/332644a0 2833705 · DOI
  40. [40]Maroun C.R. Holgado-Madruga M. Royal I. Naujokas M.A. Fournier T.M. Wong A.J. Park M. The GAB1 PH Domain Is Required for Localization of GAB1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase Mol. Cell. Biol. 1999 19 1784 1799 10.1128/MCB.19.3.1784 10022866 PMC83972 · DOI
  41. [41]Maroun C.R. Moscatello D.K. Naujokas M.A. Holgado-Madruga M. Wong A.J. Park M. A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the GAB1 Docking Protein Is Required for Epithelial Morphogenesis J. Biol. Chem. 1999 274 31719 31726 10.1074/jbc.274.44.31719 10531383 · DOI
  42. [42]Cunnick J.M. Mei L. Doupnik C.A. Wu J. Phosphotyrosines 627 and 659 of GAB1 Constitute a Bisphosphoryl Tyrosine-Based Activation Motif (BTAM) Conferring Binding and Activation of SHP2 J. Biol. Chem. 2001 276 24380 24387 10.1074/jbc.M010275200 11323411 · DOI
  43. [43]Schaeper U. Gehring N.H. Fuchs K.P. Sachs M. Kempkes B. Birchmeier W. Coupling of GAB1 to C-Met, Grb2, and Shp2 Mediates Biological Responses J. Cell Biol. 2000 149 1419 1432 10.1083/jcb.149.7.1419 10871282 PMC2175135 · DOI
  44. [44]Cunnick J.M. Dorsey J.F. Munoz-Antonia T. Mei L. Wu J. Requirement of SHP2 Binding to Grb2-Associated Binder-1 for Mitogen-Activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor J. Biol. Chem. 2000 275 13842 13848 10.1074/jbc.275.18.13842 10788507 · DOI
  45. [45]Maroun C.R. Naujokas M.A. Holgado-Madruga M. Wong A.J. Park M. The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase Mol. Cell. Biol. 2000 20 8513 8525 10.1128/MCB.20.22.8513-8525.2000 11046147 PMC102157 · DOI
  46. [46]Bongartz H. Gille K. Hessenkemper W. Mandel K. Lewitzky M. Feller S.M. Schaper F. The Multi-Site Docking Protein Grb2-Associated Binder 1 (GAB1) Enhances Interleukin-6-Induced MAPK-Pathway Activation in an SHP2-, Grb2-, and Time-Dependent Manner Cell Commun. Signal. 2019 17 135 10.1186/s12964-019-0451-2 31651330 PMC6814103 · DOI
  47. [47]Lock L.S. Maroun C.R. Naujokas M.A. Park M. Distinct Recruitment and Function of GAB1 and Gab2 in Met Receptor-Mediated Epithelial Morphogenesis Mol. Biol. Cell 2002 13 2132 2146 10.1091/mbc.02-02-0031 12058075 PMC117630 · DOI
  48. [48]Galabova-Kovacs G. Matzen D. Piazzolla D. Meissl K. Plyushch T. Chen A.P. Silva A. Baccarini M. Essential Role of B-Raf in ERK Activation during Extraembryonic Development Proc. Natl. Acad. Sci. USA 2006 103 1325 1330 10.1073/pnas.0507399103 16432225 PMC1360532 · DOI
  49. [49]Shi Z.-Q. Yu D.-H. Park M. Marshall M. Feng G.-S. Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity Mol. Cell. Biol. 2000 20 1526 1536 10.1128/MCB.20.5.1526-1536.2000 10669730 PMC85329 · DOI
  50. [50]Mattoon D.R. Lamothe B. Lax I. Schlessinger J. The Docking Protein GAB1 Is the Primary Mediator of EGF-Stimulated Activation of the PI-3K/Akt Cell Survival Pathway BMC Biol. 2004 2 24 10.1186/1741-7007-2-24 15550174 PMC534114 · DOI
  51. [51]Hoeben A. Martin D. Clement P.M. Cools J. Gutkind J.S. Role of GRB2-Associated Binder 1 in Epidermal Growth Factor Receptor-Induced Signaling in Head and Neck Squamous Cell Carcinoma Int. J. Cancer 2013 132 1042 1050 10.1002/ijc.27763 22865653 PMC3498529 · DOI
  52. [52]Paliouras G.N. Naujokas M.A. Park M. Pak4, a Novel GAB1 Binding Partner, Modulates Cell Migration and Invasion by the Met Receptor Mol. Cell. Biol. 2009 29 3018 3032 10.1128/MCB.01286-08 19289496 PMC2682017 · DOI
  53. [53]Watanabe T. Tsuda M. Makino Y. Ichihara S. Sawa H. Minami A. Mochizuki N. Nagashima K. Tanaka S. Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor-Induced Cell Motility of Human Synovial Sarcoma Cell Lines Mol. Cancer Res. 2006 4 499 510 10.1158/1541-7786.MCR-05-0141 16849525 · DOI
  54. [54]Sakkab D. Lewitzky M. Posern G. Schaeper U. Sachs M. Birchmeier W. Feller S.M. Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein GAB1 and the Adapter Protein CRKL J. Biol. Chem. 2000 275 10772 10778 10.1074/jbc.275.15.10772 10753869 · DOI
  55. [55]Yang Z. Xue B. Umitsu M. Ikura M. Muthuswamy S.K. Neel B.G. The Signaling Adaptor GAB1 Regulates Cell Polarity by Acting as a PAR Protein Scaffold Mol. Cell 2012 47 469 483 10.1016/j.molcel.2012.06.037 22883624 PMC3462001 · DOI
  56. [56]Gual P. Giordano S. Williams T.A. Rocchi S. Van Obberghen E. Comoglio P.M. Sustained Recruitment of Phospholipase C-Gamma to GAB1 Is Required for HGF-Induced Branching Tubulogenesis Oncogene 2000 19 1509 1518 10.1038/sj.onc.1203514 10734310 · DOI
  57. [57]Kapoor G.S. Zhan Y. Johnson G.R. O’Rourke D.M. Distinct Domains in the SHP-2 Phosphatase Differentially Regulate Epidermal Growth Factor Receptor/NF-KappaB Activation through GAB1 in Glioblastoma Cells Mol. Cell. Biol. 2004 24 823 836 10.1128/MCB.24.2.823-836.2004 14701753 PMC343802 · DOI
  58. [58]Chang C.-H. Chan P.-C. Li J.-R. Chen C.-J. Shieh J.-J. Fu Y.-C. Chen H.-C. Wu M.-J. GAB1 Is Essential for Membrane Translocation, Activity and Integrity of MTORCs after EGF Stimulation in Urothelial Cell Carcinoma Oncotarget 2015 6 1478 1489 10.18632/oncotarget.2756 25596749 PMC4359308 · DOI
  59. [59]Huber M. Helgason C.D. Damen J.E. Liu L. Humphries R.K. Krystal G. The Src Homology 2-Containing Inositol Phosphatase (SHIP) Is the Gatekeeper of Mast Cell Degranulation Proc. Natl. Acad. Sci. USA 1998 95 11330 11335 10.1073/pnas.95.19.11330 9736736 PMC21642 · DOI
  60. [60]Wöhrle F.U. Daly R.J. Brummer T. Function, Regulation and Pathological Roles of the Gab/DOS Docking Proteins Cell Commun. Signal. 2009 7 22 10.1186/1478-811X-7-22 19737390 PMC2747914 · DOI
  61. [61]Zhang S.Q. Tsiaras W.G. Araki T. Wen G. Minichiello L. Klein R. Neel B.G. Receptor-Specific Regulation of Phosphatidylinositol 3’-Kinase Activation by the Protein Tyrosine Phosphatase Shp2 Mol. Cell. Biol. 2002 22 4062 4072 10.1128/MCB.22.12.4062-4072.2002 12024020 PMC133866 · DOI
  62. [62]Montagner A. Yart A. Dance M. Perret B. Salles J.-P. Raynal P. A Novel Role for GAB1 and SHP2 in Epidermal Growth Factor-Induced Ras Activation J. Biol. Chem. 2005 280 5350 5360 10.1074/jbc.M410012200 15574420 · DOI
  63. [63]Yu C.F. Liu Z.-X. Cantley L.G. ERK Negatively Regulates the Epidermal Growth Factor-Mediated Interaction of GAB1 and the Phosphatidylinositol 3-Kinase J. Biol. Chem. 2002 277 19382 19388 10.1074/jbc.M200732200 11896055 · DOI
  64. [64]Roshan B. Kjelsberg C. Spokes K. Eldred A. Crovello C.S. Cantley L.G. Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1 J. Biol. Chem. 1999 274 36362 36368 10.1074/jbc.274.51.36362 10593929 · DOI
  65. [65]Gual P. Giordano S. Anguissola S. Parker P.J. Comoglio P.M. GAB1 Phosphorylation: A Novel Mechanism for Negative Regulation of HGF Receptor Signaling Oncogene 2001 20 156 166 10.1038/sj.onc.1204047 11313945 · DOI
  66. [66]Yu C.F. Roshan B. Liu Z.X. Cantley L.G. ERK Regulates the Hepatocyte Growth Factor-Mediated Interaction of GAB1 and the Phosphatidylinositol 3-Kinase J. Biol. Chem. 2001 276 32552 32558 10.1074/jbc.M104493200 11445578 · DOI · Paper page
  67. [67]Mizutani N. Hikita H. Saito Y. Myojin Y. Sato K. Urabe M. Kurahashi T. Shiode Y. Sakane S. Murai K. GAB1 in Livers with Persistent Hepatocyte Apoptosis Has an Antiapoptotic Effect and Reduces Chronic Liver Injury, Fibrosis, and Tumorigenesis Am. J. Physiol.—Gastrointest. Liver Physiol. 2021 320 G958 G968 10.1152/ajpgi.00370.2020 33787344 · DOI
  68. [68]Zhou L. Shao C.-Y. Xie Y.-J. Wang N. Xu S.-M. Luo B.-Y. Wu Z.-Y. Ke Y.H. Qiu M. Shen Y. GAB1 Mediates PDGF Signaling and Is Essential to Oligodendrocyte Differentiation and CNS Myelination eLife 2020 9 e52056 10.7554/eLife.52056 31944179 PMC6984811 · DOI
  69. [69]Lu Y. Xiong Y. Huo Y. Han J. Yang X. Zhang R. Zhu D.-S. Klein-Hessling S. Li J. Zhang X. Grb-2-Associated Binder 1 (GAB1) Regulates Postnatal Ischemic and VEGF-Induced Angiogenesis through the Protein Kinase A-Endothelial NOS Pathway Proc. Natl. Acad. Sci. USA 2011 108 2957 2962 10.1073/pnas.1009395108 21282639 PMC3041066 · DOI
  70. [70]Shi X. Liu Q. Zhao H. Lu J. Huang Y. Ma Y. Xia J. Liu M. Tu W. Jin L. Increased Expression of GAB1 Promotes Inflammation and Fibrosis in Systemic Sclerosis Exp. Dermatol. 2019 28 1313 1320 10.1111/exd.14033 31505074 · DOI
  71. [71]Holgado-Madruga M. Badal S. Wong A.J. Abstract 314: Characterization of the Y83C GAB1 Mutation in Breast Cancer Cancer Res. 2010 70 314 10.1158/1538-7445.AM10-314 · DOI
  72. [72]Ortiz-Padilla C. Gallego-Ortega D. Browne B.C. Hochgräfe F. Caldon C.E. Lyons R.J. Croucher D.R. Rickwood D. Ormandy C.J. Brummer T. Functional Characterization of Cancer-Associated GAB1 Mutations Oncogene 2013 32 2696 2702 10.1038/onc.2012.271 22751113 · DOI
  73. [73]Agaimy A. Perret R. Demicco E.G. Gross J. Liu Y.J. Azmani R. Engelmann C. Schubart C. Seppet J. Stoehr R. GAB1::ABL1 Fusions Define a Distinctive Soft Tissue Neoplasm, with Variable Perineurial Differentiation, and a Predilection for Children and Young Adults Genes. Chromosomes Cancer 2023 62 449 459 10.1002/gcc.23131 36744864 · DOI
  74. [74]Enrico D. Lacroix L. Chen J. Rouleau E. Scoazec J.-Y. Loriot Y. Tselikas L. Jovelet C. Planchard D. Gazzah A. Oncogenic Fusions May Be Frequently Present at Resistance of EGFR Tyrosine Kinase Inhibitors in Patients with NSCLC: A Brief Report JTO Clin. Res. Rep. 2020 1 100023 10.1016/j.jtocrr.2020.100023 34589930 PMC8474286 · DOI
  75. [75]Kumaran M. Cass C.E. Graham K. Mackey J.R. Hubaux R. Lam W. Yasui Y. Damaraju S. Germline Copy Number Variations Are Associated with Breast Cancer Risk and Prognosis Sci. Rep. 2017 7 14621 10.1038/s41598-017-14799-7 29116104 PMC5677082 · DOI
  76. [76]Meng L.-Q. Essential Role of Polymorphism of GAB1, EGFR, and EGF for the Susceptibility of Biliary Tract Cancer Tumour Biol. J. Int. Soc. Oncodev. Biol. Med. 2014 35 12497 12508 10.1007/s13277-014-2568-7 25217982 · DOI
  77. [77]Wang G. Heij L.R. Liu D. Dahl E. Lang S.A. Ulmer T.F. Luedde T. Neumann U.P. Bednarsch J. The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review Cancers 2022 14 5969 10.3390/cancers14235969 36497451 PMC9739277 · DOI
  78. [78]Chen W. Zhao J. Wu Q. Yan H. Wang X. Nan C. Wu Z. Chen L. Zhao Z. Association of Single-Nucleotide Polymorphisms of GAB1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 2021 27 e933444 10.12659/MSM.933444 PMC8577039 34732686 · DOI
  79. [79]Li X. Li X. Ren Y. Yin Z. Quan X. Xue X. Zhou B. Polymorphisms of Rs1347093 and Rs1397529 Are Associated with Lung Cancer Risk in Northeast Chinese Population Oncotarget 2017 8 94862 94871 10.18632/oncotarget.22030 29212272 PMC5706918 · DOI
  80. [80]Liu H. Li G. Zeng W. Zhang P. Fan F. Tu Y. Zhang Y. Combined Detection of GAB1 and Gab2 Expression Predicts Clinical Outcome of Patients with Glioma Med. Oncol. 2014 31 77 10.1007/s12032-014-0077-6 24998422 · DOI
  81. [81]Zhang Y. Li Z. Yang M. Wang D. Yu L. Guo C. Guo X. Lin N. Identification of GRB2 and GAB1 Coexpression as an Unfavorable Prognostic Factor for Hepatocellular Carcinoma by a Combination of Expression Profile and Network Analysis PLoS ONE 2013 8 e85170 10.1371/journal.pone.0085170 24391994 PMC3877332 · DOI
  82. [82]Hu L. Liu R. Expression of GAB1 Is Associated with Poor Prognosis of Patients with Epithelial Ovarian Cancer Tohoku J. Exp. Med. 2016 239 177 184 10.1620/tjem.239.177 27302321 · DOI
  83. [83]Boetto J. Bielle F. Tran S. Marijon P. Peyre M. Rigau V. Kalamarides M. GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma Neurosurgery 2023 92 391 397 10.1227/neu.0000000000002209 36637273 · DOI
  84. [84]Boetto J. Lerond J. Peyre M. Tran S. Marijon P. Kalamarides M. Bielle F. GAB1 Overexpression Identifies Hedgehog-Activated Anterior Skull Base Meningiomas Neuropathol. Appl. Neurobiol. 2021 47 748 755 10.1111/nan.12740 34056767 · DOI
  85. [85]Chen J. Kang Z. Li S. Wang C. Zheng X. Cai Z. Pan L. Chen F. Li W. Molecular Profile Reveals Immune-Associated Markers of Medulloblastoma for Different Subtypes Front. Immunol. 2022 13 911260 10.3389/fimmu.2022.911260 35967388 PMC9367478 · DOI
  86. [86]Al-Husseinawi E. Bui M.M. Ahmed A.A. Grb2-Associated Binding Protein-1 as a Biomarker in Bone and Soft Tissue Sarcomas Pathology 2019 51 610 614 10.1016/j.pathol.2019.05.003 31443923 · DOI
  87. [87]Hanahan D. Weinberg R.A. The Hallmarks of Cancer Cell 2000 100 57 70 10.1016/S0092-8674(00)81683-9 10647931 · DOI · Paper page
  88. [88]Hanahan D. Weinberg R.A. Hallmarks of Cancer: The next Generation Cell 2011 144 646 674 10.1016/j.cell.2011.02.013 21376230 · DOI · Paper page
  89. [89]Mood K. Saucier C. Bong Y.-S. Lee H.-S. Park M. Daar I.O. GAB1 Is Required for Cell Cycle Transition, Cell Proliferation, and Transformation Induced by an Oncogenic Met Receptor Mol. Biol. Cell 2006 17 3717 3728 10.1091/mbc.e06-03-0244 16775003 PMC1556377 · DOI
  90. [90]Sang H. Li T. Li H. Liu J. Down-Regulation of GAB1 Inhibits Cell Proliferation and Migration in Hilar Cholangiocarcinoma PLoS ONE 2013 8 e81347 10.1371/journal.pone.0081347 24312291 PMC3842939 · DOI
  91. [91]Fan Y. Yang F. Cao X. Chen C. Zhang X. Zhang X. Lin W. Wang X. Liang C. GAB1 Regulates SDF-1-Induced Progression via Inhibition of Apoptosis Pathway Induced by PI3K/AKT/Bcl-2/BAX Pathway in Human Chondrosarcoma Tumour Biol. J. Int. Soc. Oncodev. Biol. Med. 2016 37 1141 1149 10.1007/s13277-015-3815-2 26276357 · DOI
  92. [92]Kameda H. Risinger J.I. Han B.B. Baek S.J. Barrett J.C. Abe T. Takeuchi T. Glasgow W.C. Eling T.E. Expression of GAB1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression Mol. Cell. Biol. 2001 21 6895 6905 10.1128/MCB.21.20.6895-6905.2001 11564873 PMC99866 · DOI
  93. [93]Xu L. Li J. Kuang Z. Kuang Y. Wu H. Knockdown of GAB1 Inhibits Cellular Proliferation, Migration, and Invasion in Human Oral Squamous Carcinoma Cells Oncol. Res. 2018 26 617 624 10.3727/096504017X15043589260618 28893350 PMC7844679 · DOI
  94. [94]Shao N.-Y. Wang D.-X. Wang Y. Li Y. Zhang Z.-Q. Jiang Q. Luo W. Cao C. MicroRNA-29a-3p Downregulation Causes GAB1 Upregulation to Promote Glioma Cell Proliferation Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. 2018 48 450 460 10.1159/000491776 30016785 · DOI
  95. [95]Sun W. Zhang Z. Wang J. Shang R. Zhou L. Wang X. Duan J. Ruan B. Gao Y. Dai B. MicroRNA-150 Suppresses Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Inhibiting the GAB1-ERK Axis Oncotarget 2016 7 11595 11608 10.18632/oncotarget.7292 26871477 PMC4905496 · DOI
  96. [96]Li J. Yang N. Tian X. Ouyang L. Jiang M. Zhang S. Interference of PTK6/GAB1 Signaling Inhibits Cell Proliferation, Invasion, and Migration of Cervical Cancer Cells Mol. Med. Rep. 2022 26 284 10.3892/mmr.2022.12800 35894144 PMC9366152 · DOI
  97. [97]Gillgrass A. Cardiff R.D. Sharan N. Kannan S. Muller W.J. Epidermal Growth Factor Receptor-Dependent Activation of GAB1 Is Involved in ErbB-2-Mediated Mammary Tumor Progression Oncogene 2003 22 9151 9155 10.1038/sj.onc.1206983 14668796 · DOI
  98. [98]Yamasaki S. Nishida K. Yoshida Y. Itoh M. Hibi M. Hirano T. GAB1 Is Required for EGF Receptor Signaling and the Transformation by Activated ErbB2 Oncogene 2003 22 1546 1556 10.1038/sj.onc.1206284 12629518 · DOI
  99. [99]Verma S. Vaughan T. Bunting K.D. Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease Adv. Hematol. 2012 2012 380635 10.1155/2012/380635 22216034 PMC3246295 · DOI
  100. [100]Xiang Y.-P. Xiao T. Li Q.-G. Lu S.-S. Zhu W. Liu Y.-Y. Qiu J.-Y. Song Z.-H. Huang W. Yi H. Y772 Phosphorylation of EphA2 Is Responsible for EphA2-Dependent NPC Nasopharyngeal Carcinoma Growth by Shp2/Erk-1/2 Signaling Pathway Cell Death Dis. 2020 11 709 10.1038/s41419-020-02831-0 32848131 PMC7449971 · DOI
  101. [101]An H.-J. Kwak S.-Y. Yoo J.-O. Kim J.-S. Bae I.-H. Park M.-J. Cho M.-Y. Kim J. Han Y.-H. Novel MiR-5582-5p Functions as a Tumor Suppressor by Inducing Apoptosis and Cell Cycle Arrest in Cancer Cells through Direct Targeting of GAB1, SHC1, and CDK2 Biochim. Biophys. Acta 2016 1862 1926 1937 10.1016/j.bbadis.2016.07.017 27475256 · DOI
  102. [102]Su Q.-L. Zhao H.-J. Song C.-F. Zhao S. Tian Z.-S. Zhou J.-J. MicroRNA-383 Suppresses Pancreatic Carcinoma Development via Inhibition of GAB1 Expression Eur. Rev. Med. Pharmacol. Sci. 2019 23 10729 10739 10.26355/eurrev_201912_19774 31858540 · DOI
  103. [103]Griffioen A.W. Dudley A.C. Angiogenesis: A Year in Review Angiogenesis 2021 24 195 196 10.1007/s10456-021-09798-2 34050879 PMC8164393 · DOI
  104. [104]Folkman J. Anti-Angiogenesis: New Concept for Therapy of Solid Tumors Ann. Surg. 1972 175 409 416 10.1097/00000658-197203000-00014 5077799 PMC1355186 · DOI
  105. [105]Parangi S. O’Reilly M. Christofori G. Holmgren L. Grosfeld J. Folkman J. Hanahan D. Antiangiogenic Therapy of Transgenic Mice Impairs de Novo Tumor Growth Proc. Natl. Acad. Sci. USA 1996 93 2002 2007 10.1073/pnas.93.5.2002 8700875 PMC39899 · DOI
  106. [106]Li T. Kang G. Wang T. Huang H. Tumor Angiogenesis and Anti-Angiogenic Gene Therapy for Cancer Oncol. Lett. 2018 16 687 702 10.3892/ol.2018.8733 29963134 PMC6019900 · DOI
  107. [107]Dor Y. Porat R. Keshet E. Vascular Endothelial Growth Factor and Vascular Adjustments to Perturbations in Oxygen Homeostasis Am. J. Physiol. Cell Physiol. 2001 280 C1367 C1374 10.1152/ajpcell.2001.280.6.C1367 11350731 · DOI
  108. [108]Zhao J. Wang W. Ha C.H. Kim J.Y. Wong C. Redmond E.M. Hamik A. Jain M.K. Feng G.-S. Jin Z.G. Endothelial Grb2-Associated Binder 1 Is Crucial for Postnatal Angiogenesis Arterioscler. Thromb. Vasc. Biol. 2011 31 1016 1023 10.1161/ATVBAHA.111.224493 21372298 PMC3094153 · DOI
  109. [109]Li T. Tian Y. Ren W. Chen P. Luo M. Sang H. GAB1 Regulates Invadopodia and Autocrine VEGF through SHP2/ERK1/2 in Hilar Cholangiocarcinoma Cells Am. J. Transl. Res. 2022 14 8934 8946 36628230 PMC9827304
  110. [110]Takeuchi S. Wang W. Li Q. Yamada T. Kita K. Donev I.S. Nakamura T. Matsumoto K. Shimizu E. Nishioka Y. Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer Am. J. Pathol. 2012 181 1034 1043 10.1016/j.ajpath.2012.05.023 22789825 · DOI
  111. [111]Wang W. Xu S. Yin M. Jin Z.G. Essential Roles of GAB1 Tyrosine Phosphorylation in Growth Factor-Mediated Signaling and Angiogenesis Int. J. Cardiol. 2015 181 180 184 10.1016/j.ijcard.2014.10.148 25528308 PMC4385407 · DOI
  112. [112]Steeg P.S. Tumor Metastasis: Mechanistic Insights and Clinical Challenges Nat. Med. 2006 12 895 904 10.1038/nm1469 16892035 · DOI
  113. [113]Valastyan S. Weinberg R.A. Tumor Metastasis: Molecular Insights and Evolving Paradigms Cell 2011 147 275 292 10.1016/j.cell.2011.09.024 22000009 PMC3261217 · DOI · Paper page
  114. [114]Chen S.-Y. Ma D.-N. Chen Q.-D. Zhang J.-J. Tian Y.-R. Wang Z.-C. Cai H. Lin Y. Sun H.-C. MicroRNA-200a Inhibits Cell Growth and Metastasis by Targeting Foxa2 in Hepatocellular Carcinoma J. Cancer 2017 8 617 625 10.7150/jca.17394 28367241 PMC5370505 · DOI
  115. [115]Bai R. Weng C. Dong H. Li S. Chen G. Xu Z. MicroRNA-409-3p Suppresses Colorectal Cancer Invasion and Metastasis Partly by Targeting GAB1 Expression Int. J. Cancer 2015 137 2310 2322 10.1002/ijc.29607 25991585 · DOI
  116. [116]Sang H. Li T. Li H. Liu J. GAB1 Regulates Proliferation and Migration through the PI3K/Akt Signaling Pathway in Intrahepatic Cholangiocarcinoma Tumour Biol. J. Int. Soc. Oncodev. Biol. Med. 2015 36 8367 8377 10.1007/s13277-015-3590-0 26014518 · DOI
  117. [117]Song P. Xu H. He Y. Sun J. Xu Z. Huang P. Ge M. Zhang X. Ke Y. Cheng H. GAB1 Is Upregulated to Promote Anaplastic Thyroid Cancer Cell Migration through AKT-MDR1 Biochem. Biophys. Res. Commun. 2022 607 36 43 10.1016/j.bbrc.2022.03.101 35366541 · DOI
  118. [118]Murray D.W. Didier S. Chan A. Paulino V. Van Aelst L. Ruggieri R. Tran N.L. Byrne A.T. Symons M. Guanine Nucleotide Exchange Factor Dock7 Mediates HGF-Induced Glioblastoma Cell Invasion via Rac Activation Br. J. Cancer 2014 110 1307 1315 10.1038/bjc.2014.39 24518591 PMC3950876 · DOI · Paper page
  119. [119]Seda V. Vojackova E. Ondrisova L. Kostalova L. Sharma S. Loja T. Mladonicka Pavlasova G. Zicha D. Kudlickova Peskova M. Krivanek J. FoxO1-GAB1 Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia Blood 2021 138 758 772 10.1182/blood.2020008101 33786575 PMC8513669 · DOI
  120. [120]Wang X. Peng J. Yang Z. Zhou P.-J. An N. Wei L. Zhu H.H. Lu J. Fang Y.-X. Gao W.-Q. Elevated Expression of GAB1 Promotes Breast Cancer Metastasis by Dissociating the PAR Complex J. Exp. Clin. Cancer Res. 2019 38 27 10.1186/s13046-019-1025-2 30665442 PMC6341703 · DOI
  121. [122]Kalluri R. Weinberg R.A. The Basics of Epithelial-Mesenchymal Transition J. Clin. Investig. 2009 119 1420 1428 10.1172/JCI39104 19487818 PMC2689101 · DOI · Paper page
  122. [123]Matsumoto R. Tsuda M. Wang L. Maishi N. Abe T. Kimura T. Tanino M. Nishihara H. Hida K. Ohba Y. Adaptor Protein CRK Induces Epithelial-Mesenchymal Transition and Metastasis of Bladder Cancer Cells through HGF/c-Met Feedback Loop Cancer Sci. 2015 106 709 717 10.1111/cas.12662 25816892 PMC4471787 · DOI
  123. [124]Lennon F.E. Mirzapoiazova T. Mambetsariev B. Poroyko V.A. Salgia R. Moss J. Singleton P.A. The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer PLoS ONE 2014 9 e91577 10.1371/journal.pone.0091577 24662916 PMC3963855 · DOI
  124. [125]Buonato J.M. Lan I.S. Lazzara M.J. EGF Augments TGFβ-Induced Epithelial-Mesenchymal Transition by Promoting SHP2 Binding to GAB1 J. Cell Sci. 2015 128 3898 3909 10.1242/jcs.169599 26359300 · DOI
  125. [126]De Wever O. Mareel M. Role of Tissue Stroma in Cancer Cell Invasion J. Pathol. 2003 200 429 447 10.1002/path.1398 12845611 · DOI · Paper page
  126. [127]Joyce J.A. Pollard J.W. Microenvironmental Regulation of Metastasis Nat. Rev. Cancer 2009 9 239 252 10.1038/nrc2618 19279573 PMC3251309 · DOI · Paper page
  127. [128]Cardoso A.P. Pinto M.L. Pinto A.T. Oliveira M.I. Pinto M.T. Gonçalves R. Relvas J.B. Figueiredo C. Seruca R. Mantovani A. Macrophages Stimulate Gastric and Colorectal Cancer Invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt Phosphorylation and SmallGTPase Activity Oncogene 2014 33 2123 2133 10.1038/onc.2013.154 23644655 · DOI
  128. [129]Dagogo-Jack I. Shaw A.T. Tumour Heterogeneity and Resistance to Cancer Therapies Nat. Rev. Clin. Oncol. 2018 15 81 94 10.1038/nrclinonc.2017.166 29115304 · DOI · Paper page
  129. [130]Chen H. Lin C. Peng T. Hu C. Lu C. Li L. Wang Y. Han R. Feng M. Sun F. Metformin Reduces HGF-Induced Resistance to Alectinib via the Inhibition of GAB1 Cell Death Dis. 2020 11 111 10.1038/s41419-020-2307-5 32041944 PMC7010683 · DOI
  130. [131]Adachi Y. Watanabe K. Kita K. Kitai H. Kotani H. Sato Y. Inase N. Yano S. Ebi H. Resistance Mediated by Alternative Receptor Tyrosine Kinases in FGFR1-Amplified Lung Cancer Carcinogenesis 2017 38 1063 1072 10.1093/carcin/bgx091 28968756 · DOI
  131. [132]Caenepeel S. Cooke K. Wadsworth S. Huang G. Robert L. Moreno B.H. Parisi G. Cajulis E. Kendall R. Beltran P. MAPK Pathway Inhibition Induces MET and GAB1 Levels, Priming BRAF Mutant Melanoma for Rescue by Hepatocyte Growth Factor Oncotarget 2017 8 17795 17809 10.18632/oncotarget.14855 28147313 PMC5392287 · DOI
  132. [133]Nishihara S. Yamaoka T. Ishikawa F. Ohmori T. Ando K. Kusumoto S. Kishino Y. Manabe R. Hasebe Y. Sagara H. Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation Cells 2022 11 2201 10.3390/cells11142201 35883645 PMC9319811 · DOI
  133. [134]Yamada T. Takeuchi S. Kita K. Bando H. Nakamura T. Matsumoto K. Yano S. Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer 2012 7 272 280 10.1097/JTO.0b013e3182398e69 22089117 · DOI
  134. [135]Kurupi R. Floros K.V. Jacob S. Chawla A.T. Cai J. Hu B. Puchalapalli M. Coon C.M. Khatri R. Crowther G.S. Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-Epiregulin HNSCC via GAB1 Cancer Res. Commun. 2022 2 1061 1074 10.1158/2767-9764.CRC-21-0137 36506869 PMC9728803 · DOI
  135. [136]Pennacchietti S. Cazzanti M. Bertotti A. Rideout W.M. 3rd Han M. Gyuris J. Perera T. Comoglio P.M. Trusolino L. Michieli P. Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs Cancer Res. 2014 74 6598 6609 10.1158/0008-5472.CAN-14-0761 25217525 · DOI
  136. [137]Malash I. Mansour O. Gaafar R. Shaarawy S. Abdellateif M.S. Ahmed O.S. Zekri A.-R.N. Bahnassy A. Her2/EGFR-PDGFR Pathway Aberrations Associated with Tamoxifen Response in Metastatic Breast Cancer Patients J. Egypt. Natl. Canc. Inst. 2022 34 31 10.1186/s43046-022-00132-5 35871690 PMC13314244 · DOI
  137. [138]Podar K. Tai Y.-T. Abtahi D. Raab M.S. Yasui H. Ishitsuka K. Shiraishi N. Catley L.P. Sattler M. Raje N. Targeting Src-Family Kinase Activation and Downstream Molecular Events to Overcome MM Cell Growth, Survival, and Drug-Resistance Blood 2005 106 1583 10.1182/blood.V106.11.1583.1583 · DOI
  138. [139]Baskar R. Lee K.A. Yeo R. Yeoh K.-W. Cancer and Radiation Therapy: Current Advances and Future Directions Int. J. Med. Sci. 2012 9 193 199 10.7150/ijms.3635 22408567 PMC3298009 · DOI
  139. [140]De Bacco F. Luraghi P. Medico E. Reato G. Girolami F. Perera T. Gabriele P. Comoglio P.M. Boccaccio C. Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer J. Natl. Cancer Inst. 2011 103 645 661 10.1093/jnci/djr093 21464397 · DOI
  140. [141]Chen L. Du-Cuny L. Moses S. Dumas S. Song Z. Rezaeian A.H. Lin H.-K. Meuillet E.J. Zhang S. Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells PLoS Comput. Biol. 2015 11 e1004021 10.1371/journal.pcbi.1004021 25569504 PMC4287437 · DOI

Cited by

Sorted by citations

Authors
Pérez-Baena, M. J., Cordero-Pérez, F. J., Pérez-Losada, J., & Holgado-Madruga, M.
Affiliations
  • Instituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain
  • Departamento de Medicina Interna, Complejo Asistencial de Zamora, 49022 Zamora, Spain
  • Universidad de Salamanca (ES)
Corresponding author
Holgado-Madruga, Marina
ORCID
Venue
Cancers
Publisher
MDPI AG
Published
2023-08-20
Volume
15
Issue
16
Pages
4179
ISSN
2072-6694 (ISSN-L)
DOI
10.3390/cancers15164179
PMC
PMC10453317
OpenAlex
W4386030439
Cited by
25
References
1
Citations by year
2026: 10 · 2025: 11 · 2024: 4
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Hispana (publishedVersion, cc-by-nc-nd)
  • Gredos (University of Salamanca) (submittedVersion, cc-by-nc-nd)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
Funders
  • JPL’s lab (PID2020-118527RB-I00, PDC2021-121735-I00, CSI234P18, CSI144P20)
  • MCIN/AEI/10.13039/501100011039 (PID2020-118527RB-I00, PDC2021-121735-I00, CSI234P18, CSI144P20)
  • European Union Next Generation EU/PRTR (PID2020-118527RB-I00, PDC2021-121735-I00, CSI234P18, CSI144P20)
  • Regional Government of Castile and León (PID2020-118527RB-I00, PDC2021-121735-I00, CSI234P18, CSI144P20)
  • FPU fellowship (MINECO/FEDER) (PID2020-118527RB-I00, PDC2021-121735-I00, CSI234P18, CSI144P20)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
Keywords
Gab1, pleckstrin homology domain, SH2 domain proteins, SHP2, PI3K p85, Crk, MAPK signaling, PI3K/Akt signaling, JNK signaling, oncogenic mutations, tumor progression, apoptosis evasion, metastasis, angiogenesis, anticancer drug targets

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