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Cited by 393Wound Healing and TreatmentsMesenchymal stem cell researchPeriodontal Regeneration and Treatments

The Role of MSC in Wound Healing, Scarring and Regeneration

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Guillamat-Prats, Raquel·2021·Cells
DOI 10.3390/cells10071729PMC PMC8305394
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Abstract

Tissue repair and regeneration after damage is not completely understood, and current therapies to support this process are limited. The wound healing process is associated with cell migration and proliferation, extracellular matrix remodeling, angiogenesis and re-epithelialization. In normal conditions, a wound will lead to healing, resulting in reparation of the tissue. Several risk factors, chronic inflammation, and some diseases lead to a deficient wound closure, producing a scar that can finish with a pathological fibrosis. Mesenchymal stem/stromal cells (MSCs) are widely used for their regenerative capacity and their possible therapeutically potential. Derived products of MSCs, such as exosomes or extravesicles, have shown a therapeutic potential similar to MSCs, and these cell-free products may be interesting in clinics. MSCs or their derivative products have shown paracrine beneficial effects, regulating inflammation, modifying the fibroblast activation and production of collagen and promoting neovascularization and re-epithelialization. This review describes the effects of MSCs and their derived products in each step of the wound repair process. As well, it reviews the pre-clinical and clinical use of MSCs to benefit in skin wound healing in diabetic associated wounds and in pathophysiological fibrosis.

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  • Tissue damage and lesions in cancer sites make a pro-inflammatory environment that recruits various cells such as mesenchymal stem cells.

    “Tissue damage and lesions in cancer sites make a pro-inflammatory environment that recruits various cells such as MSCs [74–76].”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [74]

    Section 2.2, “MSCs Modifying Inflammatory Phase” (page unavailable), says that systemically administered MSCs commonly migrate to sites of damage during wound healing. It does not establish that lesions at cancer sites create a pro-inflammatory environment that recruits MSCs or other cells; the Introduction mentions cancer only as a condition for which MSCs have been used as treatment. (LLM, conf=0.86)

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Authors
Guillamat-Prats, R.
Affiliations
Lung Immunity Laboratory, Germans Trias i Pujol Research Institute (IGTP), 08914 Badalona, Spain
ORCID
Guillamat-Prats, Raquel
Venue
Cells
Publisher
MDPI AG
Published
2021-07-08
Volume
10
Issue
7
Pages
1729
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells10071729
PMC
PMC8305394
OpenAlex
W3182042652
Cited by
393
References
154
Citations by year
2026: 55 · 2025: 100 · 2024: 95 · 2023: 89 · 2022: 50 · 2021: 4
FWCI
6.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Instituto de Salud Carlos III (CP20/00133 (ISCIII-AES-2019/002067)
  • Miguel Servet-Co-funded by European Regional Development Fund/European Social Fund &quot;A way to make Eu-rope&quot;/&quot;Investing in your future&quot;. (N/A)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
mesenchymal stem cells, wound healing, scar formation, tissue regeneration, exosomes, extracellular vesicles, paracrine effects, re-epithelialization, angiogenesis, extracellular matrix remodeling, diabetic wounds, chronic inflammation, fibroblast activation, collagen synthesis
MeSH terms
Animals, Cicatrix, Humans, Regeneration, Wound Healing, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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