Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Open accessAbstract
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles. These particles could be visualized by electron microscopy and were shown to be phospholipid vesicles consisting of cholesterol, sphingomyelin, and phosphatidylcholine. They contained coimmunoprecipitating exosome-associated proteins, e.g., CD81, CD9, and Alix. These particles were purified as a homogeneous population of particles with a hydrodynamic radius of 55-65 nm by size-exclusion fractionation on a HPLC. Together these observations indicated that these particles are exosomes. These purified exosomes reduced infarct size in a mouse model of myocardial ischemia/reperfusion injury. Therefore, MSC mediated its cardioprotective paracrine effect by secreting exosomes. This novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
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MSC-derived exosomes have broad-spectrum therapeutic efficacy validated in multiple disease models.
“the broad-spectrum therapeutic efficacy of MSC-derived exosomes have also been validated in multiple disease models, including carbon tetrachloride (CCl4)-induced liver injury [16], myocardial ischemia/reperfusion injury [17], LPS-induced acute respiratory distress syndrome [18], and graft-versus-host disease [19].”
From A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties (2022) · cites this paper as [17]
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BackgroundMethodInfluentialTechniques for increasing the yield of stem cell-derived exosomes: What factors may be involved?
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- Authors
- Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., Pasterkamp, G., de Kleijn, D. P. V., & Lim, S. K.
- Affiliations
- Agency for Science, Technology and Research (SG)
- University Medical Center Utrecht (NL)
- Nanyang Technological University (SG)
- National University of Singapore (SG)
- Corresponding author
- Lim, Sai Kiang
- ORCID
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 4
- Issue
- 3
- Pages
- 214-222
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W2055424631
- Cited by
- 2,215
- References
- 29
- Citations by year
- 2026: 87 · 2025: 105 · 2024: 138 · 2023: 162 · 2022: 171 · 2021: 239 · 2020: 262 · 2019: 218 · 2018: 184 · 2017: 171 · 2016: 129 · 2015: 107 · 2014: 80 · 2013: 67 · 2012: 53
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-09-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Stem Cell Research (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- exosomes, mesenchymal stem cells, myocardial ischemia-reperfusion injury, cardioprotection, paracrine signaling, phospholipid vesicles, infarct size, tissue repair, stem cell-conditioned medium
- MeSH terms
- Animals, Calcium-Binding Proteins, Cardiotonic Agents, Chromatography, High Pressure Liquid, Disease Models, Animal, Humans, Membrane Glycoproteins, Microscopy, Electron, Reperfusion Injury, Antigens, CD, Myocardial Ischemia, Mice, Exosomes, Mesenchymal Stem Cells, Tetraspanin 28, Tetraspanin 29
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