Nestin-Expressing Cells in the Lung: The Bad and the Good Parts
Open accessAbstract
Nestin is a member of the intermediate filament family, which is expressed in a variety of stem or progenitor cells as well as in several types of malignancies. Nestin might be involved in tissue homeostasis or repair, but its expression has also been associated with processes that lead to a poor prognosis in various types of cancer. In this article, we review the literature related to the effect of nestin expression in the lung. According to most of the reports in the literature, nestin expression in lung cancer leads to an aggressive phenotype and resistance to chemotherapy as well as radiation treatments due to the upregulation of phenomena such as cell proliferation, angiogenesis, and metastasis. Furthermore, nestin may be involved in the pathogenesis of some non-cancer-related lung diseases. On the other hand, evidence also indicates that nestin-positive cells may have a role in lung homeostasis and be capable of generating various types of lung tissues. More research is necessary to establish the true value of nestin expression as a prognostic factor and therapeutic target in lung cancer in addition to its usefulness in therapeutic approaches for pulmonary diseases.
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20E treatment at doses of 0.1-100 μM significantly inhibited the expression of all CSC markers studied (ALDH, CD44, Oct4, c-Kit, Nestin).
“Figure 10 demonstrates that 20E treatment at doses of 0.1–100 µM significantly inhibited the expression of all of the CSC markers studied.”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [54]
For lung cancer, ALDH, CD44, Oct4, c-kit, and Nestin are among the most frequently observed CSCs markers that promote tumor development.
“For lung cancer, ALDH, CD44, Oct4, c-kit, and Nestin were shown to be some of the most frequently observed CSCs markers which promote tumor development [53,54,85,86,87].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [54]
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Zhang, H., Xiao, B., Li, J., Yao, W., Shen, H., & Xiang, X. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.01.005 · Cited by 13 · see citing works
Esteves, M., Monteiro, M. P., & Duarte, J. A. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103245 · Cited by 13 · see citing works
Thies, S., Friess, M., Frischknecht, L., Korol, D., Felley‐Bosco, E., Stahel, R. A., Vrugt, B., Weder, W., Opitz, I., & Soltermann, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139312 · Cited by 12 · see citing works
Ryuge, S., Sato, Y., Nagashio, R., Hiyoshi, Y., Katono, K., Igawa, S., Nakashima, H., Shiomi, K., Ichinoe, M., Murakumo, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173886 · Cited by 12 · see citing works
McGowan, S. E., & McCoy, D. M. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00511.2017 · Cited by 12 · see citing works
Ortega‐Martínez, M., Romero‐Núñez, E., Niderhauser‐García, A., de‐la‐Garza‐González, C., Áncer‐Rodríguez, J., & Jaramillo‐Rangel, G. (2013) · Cell Biology International · doi:10.1002/cbin.10031 · Cited by 10 · see citing works
Self-citationShan, Y., Chen, Y., Lai, M.-D., & Hsu, H. (2014) · Oncology Reports · doi:10.3892/or.2014.3588 · Cited by 10 · see citing works
18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours
Bromińska, B., Czepczyński, R., Gabryel, P., Jarmołowska‐Jurczyszyn, D., Janicka‐Jedyńska, M., Sawicka‐Gutaj, N., Gut, P., Bromiński, G., Dyszkiewicz, W., & Ruchała, M. (2019) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000972 · Cited by 10 · see citing works
Detection of a novel stem cell probably involved in normal turnover of the lung airway epithelium
Ortega‐Martínez, M., Rodríguez‐Flores, L. E., de‐la‐Garza‐González, C., Áncer‐Rodríguez, J., & Jaramillo‐Rangel, G. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12653 · Cited by 8 · see citing works
Self-citationNestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
Ortega‐Martínez, M., de‐la‐Garza‐González, C., Áncer‐Rodríguez, J., & Jaramillo‐Rangel, G. (2014) · International Journal of Morphology · doi:10.4067/s0717-95022014000100026 · Cited by 8 · see citing works
Self-citationWindmöller, B. A., Greiner, J. F. W., Förster, C., Wilkens, L., Mertzlufft, F., Esch, J. S. A., Kaltschmidt, B., Kaltschmidt, C., & Beshay, M. (2019) · Medicine · doi:10.1097/md.0000000000018174 · Cited by 8 · see citing works
Clinical significance of nestin and its association with survival in neuroendocrine lung tumours
Bromińska, B., Gabryel, P., Jarmołowska‐Jurczyszyn, D., Janicka‐Jedyńska, M., Trojanowski, M., Sawicka‐Gutaj, N., Czepczyński, R., Gut, P., Bromiński, G., Dyszkiewicz, W., et al. (2018) · Polish Journal of Pathology · doi:10.5114/pjp.2017.73924 · Cited by 7 · see citing works
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H., Takashima, T., Tanaka, S., Ohsawa, M., & Hirakawa, K. (2015) · Oncology Letters · doi:10.3892/ol.2015.3366 · Cited by 6 · see citing works
Vetešková, J., Kmecová, Z., Malikova, E., Dóka, G., Radik, M., Vavrinec, P., Křenek, P., & Klimas, J. (2019) · Experimental Lung Research · doi:10.1080/01902148.2019.1605426 · Cited by 6 · see citing works
Modelling Cell Invasion: A Review of What JD Murray and the Embryo Can Teach Us
Kulesa, P. M., Kasemeier‐Kulesa, J. C., Morrison, J. A., McLennan, R., McKinney, M. C., & Bailey, C. M. (2021) · Bulletin of Mathematical Biology · doi:10.1007/s11538-021-00859-7 · Cited by 5 · see citing works
Dehai, Z., & Wang, J. (2017) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.204901 · Cited by 4 · see citing works
Sha, S., Zhai, Y., Lin, C., Wang, H., Chang, Q. H., Song, S., Ren, M., & Liu, G. (2017) · Oncotarget · doi:10.18632/oncotarget.18396 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 113 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Distribution, contribution and regulation of nestin+ cells
Tong, Z., & Yin, Z. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.08.013 · Cited by 31 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works
A novel risk signature for predicting brain metastasis in patients with lung adenocarcinoma
Zhao, Y., Gu, S., Li, L., Zhao, R., Xie, S., Zhang, J., Zhou, R., Tu, L., Jiang, L., Zhang, S., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad115 · Cited by 16 · see citing works
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01099-z · Cited by 11 · see citing works
Karpenko, D. V., Михайлович, К. Н., & Bigildeev, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.993056 · Cited by 10 · see citing works
The participation of tumor residing pericytes in oral squamous cell carcinoma
do Valle, I. B., Oliveira, S. R., da Silva, J. M., Peterle, G. T., Có, A. C. G., Sousa‐Neto, S. S., Mendonça, E. F., de Arruda, J. A. A., Gomes, N. P., da Silva, G. F., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32528-1 · Cited by 7 · see citing works
Immune Privileges as a Result of Mutual Regulation of Immune and Stem Systems
Karpenko, D. V. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923110123 · Cited by 7 · see citing works
Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115502 · Cited by 5 · see citing works
Jaramillo‐Rangel, G., Chávez-Briones, M.-D.-L., Ancer-Arellano, A., Miranda-Maldonado, I. C., & Ortega‐Martínez, M. (2023) · Biomedicines · doi:10.3390/biomedicines11072075 · Cited by 5 · see citing works
Self-citationReview on the neuron damage parameters in patients with end-stage renal disease
(2023) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.47750/jptcp.2023.30.07.045 · Cited by 3 · see citing works
Huang, L., Chen, L., Wang, Y., Zhang, F., Wang, T., Li, D., Wang, C., & Ma, H. (2023) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2023.22485 · Cited by 3 · see citing works
Zarina, K. Z., & Pilmane, M. (2022) · Medical Sciences · doi:10.3390/medsci11010007 · Cited by 2 · see citing works
Liu, Y., Zhang, X., Jiang, T., & Du, N. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/9811905 · Cited by 2 · see citing works
RetractedIntermediate filaments and their associated molecules
Gao, J., & Nakamura, F. (2024) · Journal of Biomedical Research · doi:10.7555/jbr.38.20240193 · Cited by 1 · see citing works
Immune privileges as a result of mutual regulation of the immune and stem systemsPreprint
Karpenko, D. V. (2023) · doi:10.24108/preprints-3112745 · Cited by 1 · see citing works
Immune privileges as a result of mutual regulation of the immune and stem systems
Karpenko, D. V. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523110131
The expression of intermediate filaments in the abomasum of ruminants: A comparative study
AYDIN, N., Ketani, M. A., & Sağsöz, H. (2024) · Anatomia Histologia Embryologia · doi:10.1111/ahe.13088
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180984
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180963
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180966
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180975
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180981
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180969
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180972
Daido, W., Nakashima, T., Masuda, T., Sakamoto, S., Yamaguchi, K., Horimasu, Y., Miyamoto, S., Iwamoto, H., Fujitaka, K., Hamada, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24180978
- Authors
- Jaramillo-Rangel, G., Chávez-Briones, M.-D.-L., Ancer-Arellano, A., & Ortega-Martínez, M.
- Affiliations
- Department of Pathology, School of Medicine, Autonomous University of Nuevo León, Monterrey 64460, Mexico
- Universidad Autónoma de Nuevo León (MX)
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2021-12-04
- Volume
- 10
- Issue
- 12
- Pages
- 3413
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC8700449
- OpenAlex
- W4200019825
- Cited by
- 25
- References
- 113
- Citations by year
- 2024: 3 · 2023: 19 · 2022: 3
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- nestin, lung cancer, intermediate filaments, lung homeostasis, lung regeneration, chemoresistance, radioresistance (biology), angiogenesis, metastasis, cell proliferation, prognostic factors, therapeutic target, stem cells
- MeSH terms
- Aging, Animals, Humans, Lung, Lung Neoplasms, Models, Biological, Stem Cells, Nestin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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