CoChat
Sign Up
Cited by 39Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA regulation and disease

The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

Open access
Salemi, Michele, Mogavero, Maria Paola, Lanza, Giuseppe, Mongioì, Laura M., Calogero, Aldo E., Ferri, Raffaele·2022·Cells
DOI 10.3390/cells11121930PMC PMC9221903
Open this paper in CoChat — free accountOpen PDF

Abstract

Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/cells11121930

Cites

237 of 237 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 General biological mechanisms leading to neurodegenerative disease or cancer.
Figure 1 General biological mechanisms leading to neurodegenerative disease or cancer.CC BY · PubMed Central
Figure 2 Gene regulatory mechanism of ncRNA.
Figure 2 Gene regulatory mechanism of ncRNA.CC BY · PubMed Central
Figure 3 RNAs’ nomenclature and function. RNAs are classified based on their coding. Only two percent of RNAs code for proteins; most RNAs exert regulatory functions. lncRNA, long noncoding RNA; circular RNA; miRNA; microRNA; piRNA; piwi-interacting RNA; rasiRNA; repeat-associated small interfering RNA; scaRNA, small Cajal body-specific RNA; siRNA, small interfering RNA; snRNA, small nuclear RNA; snoRNA, small nucleolar RNA; tiRNA, transfer RNA; rRNA, stress-induced small RNA; tRNA, transfer RNA.
Figure 3 RNAs’ nomenclature and function. RNAs are classified based on their coding. Only two percent of RNAs code for proteins; most RNAs exert regulatory functions. lncRNA, long noncoding RNA; circular RNA; miRNA; microRNA; piRNA; piwi-interacting RNA; rasiRNA; repeat-associated small interfering RNA; scaRNA, small Cajal body-specific RNA; siRNA, small interfering RNA; snRNA, small nuclear RNA; snoRNA, small nucleolar RNA; tiRNA, transfer RNA; rRNA, stress-induced small RNA; tRNA, transfer RNA.CC BY · PubMed Central
Figure 4 Examples of inverse comorbidity between tumors and Parkinson’s disease in which the miR-519a-3p and PARP1 gene play an important role. TGCTs, testicular germ cell tumors; HCC, hepatocellular carcinoma; GM, glioblastoma multiforme. Red arrow, upregulated; green arrow, downregulated.
Figure 4 Examples of inverse comorbidity between tumors and Parkinson’s disease in which the miR-519a-3p and PARP1 gene play an important role. TGCTs, testicular germ cell tumors; HCC, hepatocellular carcinoma; GM, glioblastoma multiforme. Red arrow, upregulated; green arrow, downregulated.CC BY · PubMed Central
Figure 5 miRNAs involved in inverse comorbidity mechanisms for the modulation of neurodegeneration, carcinogenesis and circadian genes.
Figure 5 miRNAs involved in inverse comorbidity mechanisms for the modulation of neurodegeneration, carcinogenesis and circadian genes.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

2 retracted

Show all 237 references

Research works printed but not linked: 1

  1. Bella, 2017, Cell chemical biology, J. Int. Med. Res., 24, 725

Cited by

Sorted by citations

See all 39

Related

Metadata

Authors
Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R.
Affiliations
  • Istituti di Ricovero e Cura a Carattere Scientifico (IT)
  • Istituti Clinici Scientifici Maugeri (IT)
  • University of Catania (IT)
Corresponding author
Salemi, Michele
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2022-06-15
Volume
11
Issue
12
Pages
1930
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells11121930
PMC
PMC9221903
OpenAlex
W4282972028
Cited by
39
References
237
Citations by year
2026: 3 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Italian Ministry of Health (2773804)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
cancer, neurodegenerative diseases, non-coding RNA, Alzheimer's disease, Parkinson's disease, PARP1
MeSH terms
Alzheimer Disease, Humans, Neoplasms, Parkinson Disease, Comorbidity, Neurodegenerative Diseases, RNA, Untranslated

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review