Cited by 39Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA regulation and disease

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Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

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Salemi, Michele, Mogavero, Maria Paola, Lanza, Giuseppe, Mongioì, Laura M., Calogero, Aldo E., Ferri, Raffaele·2022·Cells

DOI 10.3390/cells11121930PMC PMC9221903

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Abstract

Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.

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2 retracted

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression
Yu, L., Gong, X., Sun, L., Zhou, Q., Lu, B., & Zhū, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158347 · Cited by 359
Retracted
RETRACTED ARTICLE: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway
Zhang, J., Xu, Y., Gao, Y., Chen, C., Zheng, Z.-S., Yun, M., Weng, H.-W., Xie, D., & Ye, S. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0586-y · Cited by 88
Retracted
Global cancer statistics
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Cancer Statistics, 2017.
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Sørlie, T., Perou, C. M., Tibshirani, R. J., Aas, T., Geisler, S. B., Johnsen, H., Hastie, T. J., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191367098 · Cited by 11,506
Cancer statistics, 2014
Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study
Barnett, K., Mercer, S. W., Norbury, M., Watt, G., Wyke, S., & Guthrie, B. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60240-2 · Cited by 6,972
Cancer statistics for the year 2020: An overview
Ferlay, J., Colombet, M., Soerjomataram, I., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2021) · International Journal of Cancer · doi:10.1002/ijc.33588 · Cited by 6,308
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature · doi:10.1038/nature10983 · Cited by 6,097
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,484
Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature
Park, P. Y., Goldin, T. A., Chang, J. C. S., Markman, M. M., & Kundranda, M. N. (2015) · Case Reports in Oncology · doi:10.1159/000441772 · Cited by 5,273
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,205
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expressionPreprint
Derrien, T., Johnson, R., Bussotti, G., Andrea Tanzer, A., Djebali, S., Tilgner, H., Guernec, G., Martin, D., Merkel, A., Knowles, D. G., et al. (2012) · Genome Research · doi:10.1101/gr.132159.111 · Cited by 5,135
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
Unique features of long non-coding RNA biogenesis and function
Quinn, J. J., & Chang, H. Y. (2015) · Nature Reviews Genetics · doi:10.1038/nrg.2015.10 · Cited by 3,700
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,710
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,671
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science · doi:10.1126/science.1072221 · Cited by 1,826
Role of Genes and Environments for Explaining Alzheimer Disease
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.168 · Cited by 1,798
Reduced accumulation of specific microRNAs in colorectal neoplasia.
Michael, M., Connor, S. M. O., Pellekaan, N. V. H., Young, G. P., & James, R. J. (2003) · PubMed · Cited by 1,576
The rise of regulatory RNA
Morris, K. V., & Mattick, J. S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3722 · Cited by 1,447
Amyotrophic lateral sclerosis
van Es, M. A., Hardiman, O. M., Chiò, A., Al‐Chalabi, A., Pasterkamp, R. J., Veldink, J. H., & van den Berg, L. H. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31287-4 · Cited by 1,396
Clinical Neurology and Epidemiology of the Major Neurodegenerative DiseasesPreprint
Erkkinen, M. G., Kim, M., & Geschwind, M. D. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033118 · Cited by 1,231
MicroRNA Pathways in Flies and Worms
Ambros, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00428-8 · Cited by 1,218
Pathological mechanisms in progressive multiple sclerosis
Mahad, D., Trapp, B. D., & Lassmann, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70256-x · Cited by 1,198
Parkinson's disease. Second of two parts.
Lang, A., & Lozano, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391607 · Cited by 1,193
Metformin as a tool to target aging
Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096 · cited 1×
“For instance, metformin, a biguanide for the treatment of type 2 diabetes, appears to decrease the risk of cancer, dementia and other age-related diseases through multiple mechanisms [69,70], including decreased levels of insulin and IGF–1, inhibition of the mTOR pathway, inhibition of mitochondrial function, a decrea…”
Background
Carcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082
Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
Reeve, A. K., Simcox, E. M., & Turnbull, D. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.004 · Cited by 1,013
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996
The multidimensional mechanisms of long noncoding RNA function
Marchese, F. P., Raimondi, I., & Huarte, M. (2017) · Genome biology · doi:10.1186/s13059-017-1348-2 · Cited by 985
A Prospective Study of Physical Activity and Cognitive Decline in Elderly Women: Women Who Walk
Yaffe, K., Barnes, D., Nevitt, M., Lui, L.-Y., & Covinsky, K. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.14.1703 · Cited by 921
Testicular germ-cell tumours in a broader perspective
Oosterhuis, J. W., & Looijenga, L. H. J. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1568 · Cited by 913
Risks of leukaemia and solid tumours in individuals with Down's syndrome
Hasle, H., Clemmensen, I. H., & Mikkelsen, M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05264-2 · Cited by 899
siRNA function in RNAi: A chemical modification analysis
Chiu, Y., & Rana, T. M. (2003) · RNA · doi:10.1261/rna.5103703 · Cited by 863
MALAT1 — a paradigm for long noncoding RNA function in cancer
Gutschner, T., Hämmerle, M., & Diederichs, S. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1028-y · Cited by 722
miR-221 overexpression contributes to liver tumorigenesis
Pineau, P., Volinia, S., McJunkin, K., Marchio, A., Battiston, C., Terris, B., Mazzaferro, V., Lowe, S. W., Croce, C. M., & Dejean, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907904107 · Cited by 698
Prolyl cis-trans isomerization as a molecular timer
Lu, K. P., Finn, G., Lee, T. H., & Nicholson, L. K. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.35 · Cited by 655
The epidemiology of multiple sclerosis in Europe
Pugliatti, M., Rosati, G., Carton, H., Riise, T., Drulovic, J., Vécsei, L., & Milanov, I. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01342.x · Cited by 654
Circular RNA (circRNA) in Alzheimer’s disease (AD)
Lukiw, W. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00307 · Cited by 636
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
Paul, O. H. (2007) · Frontiers in bioscience · doi:10.2741/2909 · Cited by 601
Healthy Living Is the Best Revenge
Ford, E. S., Bergmann, M. M., Kröger, J., Schienkiewitz, A., Weikert, C., & Boeing, H. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.237 · Cited by 577
Effects of Microrna-29 on Apoptosis, Tumorigenicity, and Prognosis of Hepatocellular Carcinoma
Xiong, Y., Fang, J., Yun, J., Yang, J., Zhang, Y., Jia, W.-H., & Zhuang, S. (2009) · Hepatology · doi:10.1002/hep.23380 · Cited by 571
DJ-1, a novel regulator of the tumor suppressor PTEN
Kim, R. H., Peters, M., Jang, Y., Shi, W., Pintilie, M., Fletcher, G. C., DeLuca, C., Silvester, J., Zhou, L., Snow, B. E., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.010 · Cited by 547
Circadian rhythm as a therapeutic target
Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 518
Exploring miRNA based approaches in cancer diagnostics and therapeutics
Mishra, S., Yadav, T., & Rani, V. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.003 · Cited by 500
The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling
Han, P., Li, J., Zhang, B., Lv, J., Li, Y., Gu, X.-Y., Yu, Z.-W., Jia, Y., Bai, X., Li, L., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0583-1 · Cited by 496
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
Bae, B.-I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., Taya, Y., Hayward, S. D., Moran, T. H., Montell, C., Ross, C. A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.005 · Cited by 495
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
Kam, T.-I., Mao, X., Park, H., Chou, S.-C., Karuppagounder, S. S., Umanah, G. E., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., et al. (2018) · Science · doi:10.1126/science.aat8407 · Cited by 476
Recent advances in the molecular understanding of glioblastoma
Bleeker, F. E., Molenaar, R. J., & Leenstra, S. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0793-0 · Cited by 468
Oxidative Stress and Antioxidants in Exercise
Leeuwenburgh, C., & Heinecke, J. W. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372896 · Cited by 435
Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
Driver, J. A., Beiser, A., Au, R., Kreger, B. E., Splansky, G. L., Kurth, T., Kiel, D. P., Lu, K. P., Seshadri, S., & Wolf, P. A. (2012) · BMJ · doi:10.1136/bmj.e1442 · Cited by 425
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 424
Common polygenic variation enhances risk prediction for Alzheimer’s disease
Escott-Price, V., Sims, R., Bannister, C., Harold, D., Vronskaya, M., Majounie, E., Badarinarayan, N., GERAD/PERADES, consortia, I., Morgan, K., et al. (2015) · Brain · doi:10.1093/brain/awv268 · Cited by 414
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
Xiong, H., Wang, D., Chen, L., Choo, Y. S., Ma, H., Tang, C., Xia, K., Jiang, W. B., Ronai, Z. A., Zhuang, X., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37617 · Cited by 406
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
Unoki, M., & Nakamura, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204608 · Cited by 382
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912793107 · Cited by 380
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors
Herceg, Z. (2007) · Mutagenesis · doi:10.1093/mutage/gel068 · Cited by 378
Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
Hsu, C.-C., Wahlqvist, M. L., Lee, M.-S., & Tsai, H.-N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101524 · Cited by 372
Systematic Review of miRNA as Biomarkers in Alzheimer’s Disease
Swarbrick, S., Wragg, N. M., Ghosh, S. K., & Stolzing, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1500-y · Cited by 372
A comprehensive overview and evaluation of circular RNA detection tools
Zeng, X., Lin, W., Guo, M., & Zou, Q. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005420 · Cited by 347
Biomolecular Condensates and Cancer
Boija, A., Klein, I. A., & Young, R. A. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.003 · Cited by 338
Sleep disorders and cancer: State of the art and future perspectives
Mogavero, M. P., DelRosso, L. M., Fanfulla, F., Bruni, O., & Ferri, R. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101409 · Cited by 334
Self-citation
Regulation of the p53 response and its relationship to cancer
Meek, D. W. (2015) · Biochemical Journal · doi:10.1042/bj20150517 · Cited by 311
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
Ding, J., Huang, S., Wu, S., Zhao, Y., Liang, L., Yan, M., Ge, C., Yao, J., Chen, T., Wan, D., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2039 · Cited by 307
miRNA nanotherapeutics for cancer
Ganju, A., Khan, S., Hafeez, B. B., Behrman, S. W., Yallapu, M. M., Chauhan, S. C., & Jaggi, M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.10.014 · Cited by 299
Nonsurgical Treatment of Recurrent Glioblastoma
Gallego, O. S. (2015) · Current Oncology · doi:10.3747/co.22.2436 · Cited by 296
Cancer linked to Alzheimer disease but not vascular dementia
Roe, C. M., Fitzpatrick, A. L., Xiong, C., Sieh, W., Kuller, L. H., Miller, J. P., Williams, M. M., Kopan, R., Behrens, M. I., & Morris, J. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c91873 · Cited by 288
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
Naylor, R. M., Baker, D. J., & van Deursen, J. M. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.193 · Cited by 288
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types
Ossovskaya, V., Koo, I. C., Kaldjian, E. P., Alvares, C., & Sherman, B. M. (2010) · Genes & Cancer · doi:10.1177/1947601910383418 · Cited by 283
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
Ward, A., Balwierz, A., Zhang, J. D., Kueblbeck, M., Yudi Pawitan, Y., Hielscher, T., Wiemann, S., & Şahin, Ö. (2012) · Oncogene · doi:10.1038/onc.2012.128 · Cited by 281
Impact of Age, Sex, and Comorbidity on Cancer Therapy and Disease Progression
Pal, S. K., & Hurria, A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.0579 · Cited by 266
Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors
Dong, P., Xiong, Y., Yue, J., Hanley, S. J. B., Kobayashi, N., Todo, Y., & Watari, H. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00471 · Cited by 250
Parkinson’s disease and cancer risk: a systematic review and meta-analysis
Bajaj, A., Driver, J. A., & Schernhammer, E. S. (2010) · Cancer Causes & Control · doi:10.1007/s10552-009-9497-6 · Cited by 244
Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer
Tabarés-Seisdedos, R., & Rubenstein, J. L. R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.2 · Cited by 244
Neuroprotective Role of Antidiabetic Drug Metformin Against Apoptotic Cell Death in Primary Cortical Neurons
El‐Mir, M., Détaille, D., R-Villanueva, G., Delgado‐Esteban, M., Guigas, B., Attia, S., Fontaine, E. M., Almeida, Á., & Leverve, X. M. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9002-1 · Cited by 243
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases
Pazzaglia, S., & Pioli, C. (2019) · Cells · doi:10.3390/cells9010041 · Cited by 233
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a
Toffanin, S., Hoshida, Y., Lachenmayer, A., Villanueva, A., Cabellos, L., Minguez, B., Savic, R., Ward, S. C., Thung, S., Chiang, D. Y., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.009 · Cited by 232
Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.
Kameshita, I., MATSUDA, Z., Taniguchi, T., & Shizuta, Y. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42913-9 · Cited by 225
p53‐dependent neuronal cell death in a DJ‐1‐deficient zebrafish model of Parkinson's disease
Bretaud, S., Allen, C. E., Ingham, P. W., & Bandmann, O. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04291.x · Cited by 219
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
Cusanelli, E., & Chartrand, P. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00143 · Cited by 219
miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway
Li, H., Chen, L., Li, J., Zhou, Q., Huang, A., Liu, W., Wang, K., Gao, L., Qi, S., & Lu, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0618-0 · Cited by 216
Non‐coding RNAs: biological functions and applications
Santosh, B., Varshney, A., & Yadava, P. K. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3079 · Cited by 212
Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis
Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01163.x · Cited by 209
Painting, firefighting, and shiftwork.
(2010) · PubMed Central · Cited by 207
Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies
Catalá-López, F., Suárez‐Pinilla, M., Suárez‐Pinilla, P., Valderas, J. M., Gómez-Beneyto, M., Martı́nez, S., Balanzá‐Martínez, V., Climent, J., Valencia, A., McGrath, J. J., et al. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000356498 · Cited by 203
Parkinson's disease: Evidence for environmental risk factors
Kieburtz, K. D., & Wunderle, K. B. (2012) · Movement Disorders · doi:10.1002/mds.25150 · Cited by 199
Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia
Zhang, J., Yuan, L., Zhang, X., Hamblin, M. H., Zhu, T., Meng, F., Li, Y., Chen, Y. E., & Yin, K. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.12.014 · Cited by 196
Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents.
Minniti, G. C., Muni, R., Lanzetta, G., Marchetti, P., & Enrici, R. M. (2009) · PubMed · Cited by 191
MicroRNAs and neurodegeneration: role and impact
Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy
Cai, Q., Wang, S., Jin, L., Weng, M., Zhou, D., Wang, J., Tang, Z., & Quan, Z. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1016-0 · Cited by 190
MicroRNAs in age‐related diseases
Dimmeler, S., & Nicotera, P. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201986 · Cited by 188
Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease
Lee, T. H., Pastorino, L., & Lu, K. P. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001906 · Cited by 185
Reprogramming cellular events by poly(ADP-ribose)-binding proteins
Krietsch, J., Rouleau, M., Pic, É., Ethier, C., Dawson, T. M., Dawson, V. L., Masson, J., Poirier, G. G., & Gagné, J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.005 · Cited by 185
Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence
Driver, J. A. (2014) · Biogerontology · doi:10.1007/s10522-014-9523-2 · Cited by 184
Cancer diagnosis in people with severe mental illness: practical and ethical issues
Howard, L. M., Barley, E. A., Davies, E., Rigg, A. S., Lempp, H. K., Rose, D. S., Taylor, D. M., & Thornicroft, G. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70085-1 · Cited by 182
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.026 · Cited by 165
Mendelian forms of Parkinson's disease
Gasser, T. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.007 · Cited by 165
A Prospective Cohort Study of Cancer Incidence Following the Diagnosis of Parkinson's Disease
Driver, J. A., Logroscino, G., Buring, J. E., Gaziano, J. M., & Kurth, T. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0038 · Cited by 164
PARP-1 and PARP-2: New players in tumour development.
Yélamos, J., Farrés, J., Llacuna, L., Ampurdanés, C., & Martín‐Caballero, J. (2011) · Europe PMC (PubMed Central) · Cited by 155
Parkinson's disease and cancer: two wars, one front
Devine, M. J., Plun‐Favreau, H., & Wood, N. W. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3150 · Cited by 155
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 152
Role of p53 in Neurodegenerative Diseases
Chang, J. R., Ghafouri, M., Mukerjee, R., Bagashev, A., Chabrashvili, T., & Sawaya, B. E. (2011) · Neurodegenerative Diseases · doi:10.1159/000329999 · Cited by 149
Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221
Salama, R. M., Abdel‐Latif, G. A., Abbas, S. S., Magdoub, H. M. E., & Schaalan, M. F. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107900 · Cited by 149
Chemical and structural modifications of RNAi therapeutics
Ku, S. H., Jo, S. D., Lee, Y. K., Kim, K., & Kim, S. H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.015 · Cited by 146
Investigating Black‐White differences in prostate cancer prognosis: A systematic review and meta‐analysis
Evans, S., Metcalfe, C. D., Ibrahim, F., Persad, R. A., & Ben‐Shlomo, Y. (2008) · International Journal of Cancer · doi:10.1002/ijc.23500 · Cited by 145
PARP-1 protein expression in glioblastoma multiforme
Galia, A., Calogero, A. E., Condorelli, R., Fraggetta, F., La Corte, A., Ridolfo, F., Bosco, P., Castiglione, R., & Salemi, M. (2012) · European Journal of Histochemistry · doi:10.4081/ejh.2012.e9 · Cited by 145
Self-citation
LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR‐146a
Liu, H., Fang, L., Cheng, Y., et al. (2016) · Cancer Medicine · doi:10.1002/cam4.900 · Cited by 145
Proteasome activation by small molecules
Leestemaker, Y., de Jong, A., Witting, K. F., Penning, R., Schuurman, K., Rodenko, B., Zaal, E. A., van de Kooij, B., Laufer, S., Heck, A. J. R., et al. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.05.010 · Cited by 144
Polygenic risk of P arkinson disease is correlated with disease age at onset
Escott‐Price, V., Nalls, M. A., Morris, H. R., Lubbe, S. J., Brice, A., Gasser, T., Heutink, P., Wood, N. W., Hardy, J., Singleton, A., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24335 · Cited by 142
Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway
Liu, L., Liu, F., Huang, M., et al. (2019) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2019.03.003 · Cited by 141
Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy
Ma, N., Tie, C., Yu, B., Zhang, W., & Wan, J. (2020) · Aging · doi:10.18632/aging.102785 · Cited by 140
Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients
Fernández‐Santiago, R., Carballo‐Carbajal, I., Castellano, G., Torrent, R., Richaud, Y., Sánchez‐Danés, A., Vilarrasa‐Blasi, R., Sánchez‐Pla, Á., Mosquera, J. L., Soriano, J., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505439 · Cited by 138
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases
Tabarés‐Seisdedos, R., Dumont, N., Baudot, A., Valderas, J. M., Climent, J., Valencia, A., Crespo‐Facorro, B., Vieta, E., Gómez-Beneyto, M., Martı́nez, S., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70041-9 · Cited by 138
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer
Wang, H., Meng, Q., Qian, J., Li, M., Gu, C., & Yang, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108123 · Cited by 132
A PET imaging agent for evaluating PARP-1 expression in ovarian cancer
Makvandi, M., Pantel, A. R., Schwartz, L. E., Schubert, E. K., Xu, K., Hsieh, C., Hou, C., Kim, H., Weng, C.-C., Winters, H. D., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97992 · Cited by 130
Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways
Lanni, C., Masi, M., Racchi, M., & Govoni, S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0760-2 · Cited by 130
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.
Kurosaki, T., Ushiro, H., Mitsuuchi, Y., Suzuki, S., Matsuda, M., Matsuda, Y., Katunuma, N., Kangawa, K., Matsuo, H., & Hirose, T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47687-9 · Cited by 129
CiRS‐7 targeting miR‐7 modulates the progression of non‐small cell lung cancer in a manner dependent on NF‐κB signalling
Su, C., Han, Y., Zhang, H., Li, Y., Yi, L., Wang, X., Zhou, S., Yu, D., Song, X., Xiao, N., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13587 · Cited by 127
Translatable circRNAs and lncRNAs: Driving mechanisms and functions of their translation products
Kong, S., Tao, M., Shen, X., & Ju, S. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.006 · Cited by 126
MicroRNAs: key participants in gene regulatory networks
Ke, X., Liu, C., Liu, D., & Liang, C. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00075-9 · Cited by 125
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer
Maiese, K. (2017) · Current Neurovascular Research · doi:10.2174/1567202614666170718092010 · Cited by 122
MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells
Breunig, C., Pahl, J. H. W., Kueblbeck, M., Miller, M., Antonelli, D., Erdem, N., Wirth, C., Will, R. D., Bott, A., Cerwenka, A., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.364 · Cited by 121
MicroRNA ‐519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour‐suppressor genes in ER + breast cancer
Ward, A., Shukla, K., Balwierz, A., Soons, Z. I. T. A., König, R., Şahin, Ö., & Wiemann, S. (2014) · The Journal of Pathology · doi:10.1002/path.4363 · Cited by 119
To die or grow: Parkinson's disease and cancer
WEST, A., DAWSON, V, & DAWSON, T. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.002 · Cited by 117
Association of cancer and Alzheimer's disease risk in a national cohort of veterans
Frain, L., Swanson, D., Cho, K., Gagnon, D., Lu, K. P., Betensky, R. A., & Driver, J. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.04.012 · Cited by 115
Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer
Akbarzadeh, M., Mihanfar, A., Akbarzadeh, S., Yousefi, B., & Majidinia, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119984 · Cited by 112
Long non‐coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia‐reperfusion injury
Zhao, Z., Hao, W., Meng, Q., Du, X., Lei, S., & Xia, Z. (2016) · Cell Biology International · doi:10.1002/cbin.10701 · Cited by 107
The long noncoding RNA HOTAIR promotes Parkinson’s disease by upregulating LRRK2 expression
Wang, S., Zhang, X., Guo, Y., Rong, H., & Liu, T. (2017) · Oncotarget · doi:10.18632/oncotarget.15511 · Cited by 107
Regulation of chromatin structure by poly(ADP-ribosyl)ation
Beneke, S. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00169 · Cited by 105
LncRNA PVT1 predicts prognosis and regulates tumor growth in prostate cancer
Yang, J., Cui-rong, L., Mudd, A. M., & Gu, X. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1387048 · Cited by 105
Beta-asarone protects against MPTP-induced Parkinson’s disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression
Zhang, Q., Wang, Z., Zhang, J.-L., Duan, Y.-L., Li, G.-F., & Zheng, D.-L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.017 · Cited by 104
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases
Wei, C.-W., Luo, T., Zou, S.-S., & Wu, A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00175 · Cited by 104
The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases
Prinz, F., Kapeller, A., Pichler, M., & Klec, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030627 · Cited by 102
MicroRNA expression profiling of carcinoma in situ cells of the testis
Novotny, G. W., Belling, K., Bramsen, J. B., Nielsen, J. E., Bork‐Jensen, J., Almstrup, K., Sonne, S. B., Kjems, J., Meyts, E. R., & Leffers, H. C. B. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0271 · Cited by 101
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos
Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. R., & Ba, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0680-0 · Cited by 101
Cancer and Dementia
Ganguli, M. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000086 · Cited by 100
Environment and Neurodegenerative Diseases: An Update on miRNA Role
Ferrante, M., & Conti, G. O. (2017) · MicroRNA · doi:10.2174/2211536606666170811151503 · Cited by 97
Chemotherapy in glioma
Taal, W., Bromberg, J. E. C., & van den Bent, M. J. (2015) · CNS Oncology · doi:10.2217/cns.15.2 · Cited by 96
At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its Implications
Houck, A. L., Seddighi, S., & Driver, J. A. (2018) · Current Aging Science · doi:10.2174/1874609811666180223154436 · Cited by 96
Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease
Driver, J. A., Zhou, X. Z., & Lu, K. P. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.12.025 · Cited by 95
Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer
Kesler, S. R., Watson, C., & Blayney, D. W. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.015 · Cited by 94
Pin1: A New Genetic Link between Alzheimers Disease, Cancer and Aging
Driver, J. A., & Lu, K. P. (2010) · Current Aging Science · doi:10.2174/1874609811003030158 · Cited by 92
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1
Calderwood, S. K., & Murshid, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00192 · Cited by 91
Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.
Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T., & Nakamura, Y. (2001) · PubMed · Cited by 89
CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour’s progression via miR‐7 signals
Zhang, J., Hu, H., Zhao, Y., & Zhao, Y. (2018) · Cell Proliferation · doi:10.1111/cpr.12521 · Cited by 89
Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis
Wang, C., Yang, Y., Zhang, G. C., Li, J., Wu, X., Ma, X., Shan, G., & Mei, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903432116 · Cited by 88
The Long Noncoding RNAHEALRegulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter
Chao, T., Zhang, Q., Li, Z., Tiwari, S. K., Qin, Y., Yau, E. H., Sánchez, A. B., Singh, G., Chang, K., Kaul, M., et al. (2019) · mBio · doi:10.1128/mbio.02016-19 · Cited by 85
Effects of comorbidity on screening and early diagnosis of cancer in elderly people
Terret, C., Castel-Kremer, E., Albrand, G., & Droz, J. P. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70336-x · Cited by 84
Endogenous insulin signaling protects cultured neurons from oxygen–glucose deprivation-induced cell death
Mielke, J. G., Taghibiglou, C., & Wang, Y. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.055 · Cited by 81
Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl
Paccez, J. D., Duncan, K., Sekar, D., Correa, R. G., Wang, Y., Gu, X., Bashin, M., Chibale, K., Libermann, T. A., & Zerbini, L. F. (2019) · Oncogenesis · doi:10.1038/s41389-019-0122-6 · Cited by 81
Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
Grabowska, W., Want, A., Leszek, J., & Wojda, U. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103691 · Cited by 81
The role of circadian clock genes in tumors
Li, H.-X. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s203144 · Cited by 80
MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients
Tolosa, E. S., Botta‐Orfila, T., Morató, X., Calatayud, C., Ferrer‐Lorente, R., Martı́, M. J., Fernández, M., Gaig, C., Raya, Á., Consiglio, A., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.032 · Cited by 79
Functional microRNAs in Alzheimer’s disease and cancer: differential regulation of common mechanisms and pathway
Nudelman, K. N. H., Lahiri, D. K., Schneider, B. P., Foroud, T., & Saykin, A. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2012.00323 · Cited by 77
miR-34a knockout attenuates cognitive deficits in APP/PS1 mice through inhibition of the amyloidogenic processing of APP
Jian, C., Lu, M., Zhang, Z., Liu, L., Li, X., Huang, F., Xu, N., Qin, L., Zhang, Q., & Zou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.05.023 · Cited by 77
Alzheimer disease and cancer risk: a meta-analysis
Shi, H., Tang, B., Liu, Y.-W., Wang, X., & Chen, G. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1773-5 · Cited by 74
PARKINInactivation Links Parkinson’s Disease to Melanoma
Hu, H., Kannengiesser, C., Lesage, S., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv340 · Cited by 73
Multiple sclerosis is primarily a neurodegenerative disease
Chaudhuri, A. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1080-3 · Cited by 72
An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders
Fenoglio, C., Ridolfi, E., Galimberti, D., & Scarpini, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020427 · Cited by 68
Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition
Ahmed, S. A. A., Mahmood, Z., Javed, A., Hashmi, S. N., Zerr, I., Zafar, S., & Zahid, S. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0915-z · Cited by 66
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease
Wang, L., Zhou, Y., Chen, D., & Lee, T. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00355 · Cited by 66
miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Xu, Y., Chen, P., Wang, X., Yao, J., & Zhuang, S. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.045 · Cited by 65
Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer
Peng, Y., Li, M., Clarkson, B. D. S., Pehar, M., Lao, P. J., Hillmer, A. T., Barnhart, T. E., Christian, B., Mitchell, H. A., Bendlin, B. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0077-14.2014 · Cited by 60
PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells
Matsumoto, C. S., Almeida, L. O., Guimarães, D. M., Martins, M. D., Papagerakis, P., Papagerakis, S. M., Leopoldino, A. M., CASTILHO, R. M., & SQUARIZE, C. H. (2016) · Oncotarget · doi:10.18632/oncotarget.9877 · Cited by 58
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
Lou, M.-M., Tang, X., Wang, G., He, J., Luo, F., Guan, M., Wang, F., Zou, H., Wang, J., Zhang, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24236-z · Cited by 58
RNA multimerization as an organizing force for liquid–liquid phase separation
Bevilacqua, P. C., Williams, A. M., Chou, H., & Assmann, S. M. (2021) · RNA · doi:10.1261/rna.078999.121 · Cited by 58
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue
Salemi, M., Galia, A., Fraggetta, F., CORTE, C. L., Pepe, P., Vignera, S. L., Improta, G., Bosco, P., & Calogero, A. E. (2013) · European Journal of Histochemistry · doi:10.4081/ejh.2013.e13 · Cited by 52
Self-citation
RNA-binding proteins as molecular links between cancer and neurodegeneration
Campos‐Melo, D., Droppelmann, C. A., Volkening, K., & Strong, M. J. (2014) · Biogerontology · doi:10.1007/s10522-014-9531-2 · Cited by 51
Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction
Li, J., Ma, W., Wang, P., Hurley, P. J., Bunz, F., & Hwang, P. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.022 · Cited by 48
Neurodegeneration and Cancer: Where the Disorder Prevails
Klus, P., Cirillo, D., Botta‐Orfila, T., & Tartaglia, G. G. (2015) · Scientific Reports · doi:10.1038/srep15390 · Cited by 48
Human papillomavirus and risk of prostate cancer: a systematic review and meta-analysis
Russo, G. I., Calogero, A. E., Condorelli, R. A., et al. (2018) · The Aging Male · doi:10.1080/13685538.2018.1455178 · Cited by 48
Self-citation
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade
Tsai, Y.-T., Wu, A.-C., Yang, W., Kao, T., Chuang, J., Chang, W., & Hsu, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225625 · Cited by 46
Update on intensive motor training in spinocerebellar ataxia: time to move a step forward?
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Expression of microRNAs of C19MC in Different Histological Types of Testicular Germ Cell Tumour.
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Giovannoni, G. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30127-8 · Cited by 35
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PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells
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Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock
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Salemi, M., Lanza, G., Mogavero, M. P., Cosentino, F., Borgione, E., Iorio, R., Ventola, G. M., Marchese, G., Salluzzo, M. G., Ravo, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031535 · Cited by 34
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Status of the Parkinson’s disease gene family expression in non-small-cell lung cancer
Liu, Q., Zheng, H., Deng, X. F., et al. (2015) · World Journal of Surgical Oncology · doi:10.1186/s12957-015-0646-y · Cited by 33

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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
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“…miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders, etc. 230,231 For example, miR-106b-5p is an oncogenic miRNA that appears to be upregulated in different cancers, such as hepatic cancer, 232 cervical cancer,…”
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Authors: Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R.
Affiliations: Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Istituti Clinici Scientifici Maugeri (IT)
University of Catania (IT)
Corresponding author: Salemi, Michele
ORCID: Salemi, Michele
Mogavero, Maria Paola
Lanza, Giuseppe
Mongioì, Laura M.
Calogero, Aldo E.
Ferri, Raffaele
Venue: Cells
Publisher: MDPI AG
Published: 2022-06-15
Volume: 11
Issue: 12
Pages: 1930
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells11121930
PMC: PMC9221903
OpenAlex: W4282972028
Cited by: 39
References: 237
Citations by year: 2026: 3 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 1
FWCI: 1.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Italian Ministry of Health (2773804)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: cancer, neurodegenerative diseases, non-coding RNA, Alzheimer's disease, Parkinson's disease, PARP1
MeSH terms: Alzheimer Disease, Humans, Neoplasms, Parkinson Disease, Comorbidity, Neurodegenerative Diseases, RNA, Untranslated

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Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

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