Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression

McCubrey, James A.; Yang, Li V.; Abrams, Stephen L.; Steelman, Linda S.; Follo, Matilde Y.; Cocco, Lucio; Ratti, Stefano; Martelli, Alberto M.; Augello, Giuseppa; Cervello, Melchiorre

doi:10.3390/cells11142155

Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression

Approximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are largely ineffective due to the dense desmoplastic tumor microenvironment which prevents chemotherapeutic drugs and small molecu…