Identification of Genomic Predictors of Muscle Fiber Size
Open accessAbstract
The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown. The aim of our study was to determine whether 1535 genetic variants previously identified in a genome-wide association study of appendicular lean mass are associated with the CSA of fast-twitch muscle fibers (which better predict muscle strength) in the m. vastus lateralis of 148 physically active individuals (19 power-trained and 28 endurance-trained females, age 28.0 ± 1.1; 28 power-trained and 73 endurance-trained males, age 31.1 ± 0.8). Fifty-seven single-nucleotide polymorphisms (SNPs) were identified as having an association with muscle fiber size (p < 0.05). Of these 57 SNPs, 31 variants were also associated with handgrip strength in the UK Biobank cohort (n = 359,729). Furthermore, using East Asian and East European athletic (n = 731) and non-athletic (n = 515) cohorts, we identified 16 SNPs associated with athlete statuses (sprinter, wrestler, strength, and speed–strength athlete) and weightlifting performance. All SNPs had the same direction of association, i.e., the lean mass-increasing allele was positively associated with the CSA of muscle fibers, handgrip strength, weightlifting performance, and power athlete status. In conclusion, we identified 57 genetic variants associated with both appendicular lean mass and fast-twitch muscle fiber size of m. vastus lateralis that may, in part, contribute to a greater predisposition to power sports.
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- Authors
- Guilherme, J. P. L. F., Semenova, E. A., Kikuchi, N., Homma, H., Kozuma, A., Saito, M., Zempo, H., Matsumoto, S., Kobatake, N., Nakazato, K., Okamoto, T., John, G., Yusupov, R. A., Larin, A. K., Kulemin, N. A., Gazizov, I. M., Generozov, E. V., & Ahmetov, I. I.
- Affiliations
- Universidade de São Paulo (BR)
- Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin (RU)
- Nippon Sport Science University (JP)
- Juntendo University (JP)
- Tokyo Seiei College (JP)
- Transform Specialist Medical Centre, Dubai 119190, United Arab Emirates
- Kazan State Technical University named after A. N. Tupolev (RU)
- Kazan State Medical University (RU)
- Corresponding author
- Ahmetov, Ildus I.
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2024-07-18
- Volume
- 13
- Issue
- 14
- Pages
- 1212
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC11274365
- OpenAlex
- W4400767748
- Cited by
- 11
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Liverpool John Moores University (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Science Foundation (24-15-00413, 22K11506)
- Japan Society for the Promotion of Science (24-15-00413, 22K11506)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- muscle fiber cross-sectional area, fast-twitch muscle, vastus lateralis, single nucleotide polymorphisms, genetic variants, appendicular lean mass, grip strength, weightlifting performance, power athletes, endurance athletes, sarcopenia, muscle fiber atrophy
- MeSH terms
- Adult, Female, Humans, Male, Muscle Fibers, Skeletal, Hand Strength, Polymorphism, Single Nucleotide, Genomics, Muscle Strength, Genome-Wide Association Study, Athletes
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