The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The NF-κB Pathway and Cancer Stem Cells
Open accessAbstract
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.
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Cites
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Cited by
NF-κB, inflammation, immunity and cancer: coming of age
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Targeting cancer stem cell pathways for cancer therapy
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NF‐κB signaling in inflammation and cancer
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Metadata
- Authors
- Rinkenbaugh, A., & Baldwin, A.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2016-04-06
- Volume
- 5
- Issue
- 2
- Pages
- 16
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2326647919
- Cited by
- 260
- References
- 12
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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