IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
Open accessAbstract
Using a mouse model recapitulating the main features of human chronic myelogenous leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells contributing to disease pathogenesis. We refine the characterization of CML leukemic stem cells (LSCs) to the most immature long-term hematopoietic stem cells (LT-HSCs) and identify some important molecular deregulations underlying their aberrant behavior. We find that CML multipotent progenitors (MPPs) exhibit an aberrant B-lymphoid potential but are redirected toward the myeloid lineage by the action of the proinflammatory cytokine IL-6. We show that BCR/ABL activity controls Il-6 expression thereby establishing a paracrine feedback loop that sustains CML development. These results describe how proinflammatory tumor environment affects leukemic progenitor cell fate and contributes to CML pathogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The SASP-associated cytokines TNF, IFN, and IL-6 all play significant roles in the pathogenesis of myeloproliferative neoplasms (MPNs), MDSs, and acute myeloid leukemia (AML).
“In particular, the SASP-associated cytokines TNF, IFN, and IL-6 all play significant roles in the pathogenesis of myeloproliferative neoplasms (MPNs), 52 MDSs, 53 and acute myeloid leukemia (AML).54”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 2× · see citing works
“IL-6 Contributes to CML Development To confirm the function of IL-6 in CML pathogenesis, we evaluated disease progression in the absence of IL-6 signaling by crossing BA mice with Il-6 / mice (Kopf et al., 1994).”
MethodIliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374 · see citing works
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature · doi:10.1038/nature06866 · Cited by 1,072 · see citing works
Lin28 promotes transformation and is associated with advanced human malignancies
Viswanathan, S. R., Powers, J. T., Einhorn, W. S., Hoshida, Y., Ng, T., Toffanin, S., O’Sullivan, M. J., Lü, J., Phillips, L. A., Lockhart, V. L., et al. (2009) · Nature Genetics · doi:10.1038/ng.392 · Cited by 816 · see citing works
Self-citationCorbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W., & Druker, B. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci35721 · Cited by 765 · see citing works
Huntly, B. J. P., Shigematsu, H., Deguchi, K., Lee, B. H., Mizuno, S., Duclos, N., Rowan, R., Amaral, S., Curley, D., Williams, I. R., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.015 · Cited by 697 · see citing works
Gene expression changes associated with progression and response in chronic myeloid leukemia
Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510423103 · Cited by 583 · see citing works
Self-citationHolyoake, T. L., Jiang, X., Eaves, C. J., & Eaves, A. C. (1999) · Blood · doi:10.1182/blood.v94.6.2056 · Cited by 511 · see citing works
Cell cycle regulation in hematopoietic stem cells
Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447 · see citing works
Self-citationChronic myeloid leukemia: mechanisms of blastic transformation
Perrotti, D., Jamieson, C. H. M., Goldman, J. M., & Skórski, T. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41246 · Cited by 397 · see citing works
Modeling the Initiation and Progression of Human Acute Leukemia in Mice
Barabé, F., Kennedy, J., Hope, K. J., & Dick, J. E. (2007) · Science · doi:10.1126/science.1139851 · Cited by 375 · see citing works
Interleukin‐6 and its receptor in cancer: Implications for Translational Therapeutics
Hong, D. S., Angelo, L. S., & Kurzrock, R. (2007) · Cancer · doi:10.1002/cncr.22999 · Cited by 370 · see citing works
Zhang, X., & Ren, R. (1998) · Blood · doi:10.1182/blood.v92.10.3829 · Cited by 276 · see citing works
Hu, Y., Swerdlow, S., Duffy, T. M., Weinmann, R. S., Lee, F. Y., & Li, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606509103 · Cited by 272 · see citing works
Zhang, B., Strauss, A. C., Chu, S., Li, M., Ho, Y., Shiang, K.-D., Snyder, D., Huettner, C. S., Shultz, L. D., Holyoake, T. L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.011 · Cited by 256 · see citing works
Jiang, X., Lopez, A. F., Holyoake, T. L., Eaves, A. C., & Eaves, C. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12804 · Cited by 227 · see citing works
Koschmieder, S., Göttgens, B., Zhang, P., Iwasaki-Arai, J., Akashi, K., Kutok, J. L., Dayaram, T., Geary, K., Green, A. R., Tenen, D. G., et al. (2004) · Blood · doi:10.1182/blood-2003-12-4369 · Cited by 219 · see citing works
Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential
Benveniste, P. M., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.11.014 · Cited by 217 · see citing works
A novel tumor suppressor function for the Notch pathway in myeloid leukemia
Klinakis, A., Lobry, C., Abdel-Wahab, O., Oh, P., Haeno, H., Buonamici, S., de Walle, I. V., Cathelin, S., Trimarchi, T., Araldi, E., et al. (2011) · Nature · doi:10.1038/nature09999 · Cited by 210 · see citing works
Getting to the stem of chronic myeloid leukaemia
Savona, M., & Talpaz, M. (2008) · Nature Reviews. Cancer · doi:10.1038/nrc2368 · Cited by 204 · see citing works
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition
Duy, C., Hurtz, C., Shojaee, S., Cerchietti, L. C. A., Geng, H., Swaminathan, S., Klemm, L., Kweon, S.-M., Nahar, R. R., Braig, M., et al. (2011) · Nature · doi:10.1038/nature09883 · Cited by 199 · see citing works
Santaguida, M. A., Schepers, K., King, B., Sabnis, A. J., Forsberg, E. C., Attema, J. L., Braun, B. S., & Passegue, E. A. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.016 · Cited by 156 · see citing works
Schmidt, T., Masouleh, B. K., Loges, S., Cauwenberghs, S., Fraisl, P., Maes, C., Jonckx, B., Keersmaecker, K. D., Kleppe, M., Tjwa, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.007 · Cited by 135 · see citing works
Maeda, K., Malykhin, A., Teague-Weber, B. N., Sun, X.-H., Farris, A. D., & Coggeshall, K. (2009) · Blood · doi:10.1182/blood-2008-12-192559 · Cited by 126 · see citing works
Barnes, D. J., & Melo, J. V. (2006) · Cell Cycle · doi:10.4161/cc.5.24.3573 · Cited by 117 · see citing works
Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112 · see citing works
Self-citationIL-6 blocks a discrete early step in lymphopoiesis
Maeda, K., Baba, Y., Nagai, Y., Miyazaki, K., Malykhin, A., Nakamura, K., Kincade, P. W., Sakaguchi, N., & Coggeshall, K. M. (2005) · Blood · doi:10.1182/blood-2005-02-0456 · Cited by 100 · see citing works
BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells
Schemionek, M., Elling, C., Steidl, U. G., Bäumer, N., Hamilton, A., Spieker, T., Göthert, J. R., Stehling, M., Wagers, A. J., Huettner, C. S., et al. (2010) · Blood · doi:10.1182/blood-2009-04-215376 · Cited by 95 · see citing works
Porosnicu, M., Nimmanapalli, R., Nguyen, D. N., Worthington, E., Perkins, C. L., & Bhalla, K. N. (2001) · Leukemia · doi:10.1038/sj.leu.2402104 · Cited by 94 · see citing works
Li, S., Gillessen, S., Tomasson, M. H., Dranoff, G., Gilliland, D. G., & Etten, R. A. V. (2001) · Blood · doi:10.1182/blood.v97.5.1442 · Cited by 74 · see citing works
BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production
Yu, R. Y.-L., Wang, X., Pixley, F. J., Yu, J. J., Dent, A. L., Broxmeyer, H. E., Stanley, E. R., & Ye, B. H. (2004) · Blood · doi:10.1182/blood-2004-08-3171 · Cited by 74 · see citing works
Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia
Buesche, G., Ganser, A., Schlegelberger, B., Neuhoff, N. V., Gadzicki, D., Hecker, H., Bock, O., Frye, B., & Kreipe, H. H. (2007) · Leukemia · doi:10.1038/sj.leu.2404917 · Cited by 63 · see citing works
Leukemic Stem Cells: Where do They Come From?
Passegue, E. A., & Weisman, I. L. (2005) · Stem Cell Reviews and Reports · doi:10.1385/scr:1:3:181 · Cited by 49 · see citing works
Anand, M., Chodda, S. K., Parikh, P. M., & Nadkarni, J. S. (1998) · Hematological Oncology · doi:10.1002/(sici)1099-1069(199812)16:4 · Cited by 48 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Yu, H., Lee, H., Herrmann, A., Buettner, R., & Jove, R. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3818 · Cited by 2,137 · see citing works
Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.003 · Cited by 723 · see citing works
Self-citationSchepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C., & Passegué, E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.009 · Cited by 614 · see citing works
Self-citationBone marrow niches in haematological malignancies
Méndez‐Ferrer, S., Bonnet, D. A., Steensma, D. P., Hasserjian, R. P., Ghobrial, I. M., Gribben, J. G., Andreeff, M., & Krause, D. S. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0245-2 · Cited by 486 · see citing works
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417 · see citing works
Self-citationNormal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
Schepers, K., Campbell, T., & Passegué, E. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.014 · Cited by 416 · see citing works
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works
Versatile functions for IL-6 in metabolism and cancer
Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 405 · see citing works
Giustacchini, A., Thongjuea, S., Barkas, N., Woll, P. S., Povinelli, B. J., Booth, C. A. G., Sopp, P., Norfo, R., Rodriguez-Meira, A., Ashley, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4336 · Cited by 403 · see citing works
Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.013 · Cited by 394 · see citing works
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration
Yamashita, M., & Passegué, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.019 · Cited by 387 · see citing works
Xu, X., Sun, Q., Liang, X., Chen, Z., Zhang, X., Zhou, X., Li, M., Tu, H., Liu, Y., Tu, S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02664 · Cited by 351 · see citing works
Zhang, B., Ho, Y., Huang, Q., Maeda, T., Lin, A., Lee, S.-U., Hair, A., Holyoake, T. L., Huettner, C. S., & Bhatia, R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.018 · Cited by 347 · see citing works
Kleppe, M., Kwak, M., Koppikar, P., Riester, M., Keller, M., Bastian, L., Hricik, T., Bhagwat, N., McKenney, A. S., Papalexi, E., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0736 · Cited by 317 · see citing works
The chronic myeloid leukemia stem cell: stemming the tide of persistence
Holyoake, T. L., & Vetrie, D. L. P. (2017) · Blood · doi:10.1182/blood-2016-09-696013 · Cited by 312 · see citing works
The NF-κB Pathway and Cancer Stem Cells
Rinkenbaugh, A. L., & Baldwin, A. S. (2016) · Cells · doi:10.3390/cells5020016 · Cited by 265 · see citing works
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Dong, L., Yu, W., Zheng, H., Loh, M. L., Bunting, S. T., Pauly, M. G., Huang, G., Zhou, M., Broxmeyer, H. E., Scadden, D. T., et al. (2016) · Nature · doi:10.1038/nature20131 · Cited by 260 · see citing works
Differential regulation of myeloid leukemias by the bone marrow microenvironment
Krause, D., Fulzele, K. S., Catic, A., Sun, C.-C., Dombkowski, D., Hurley, M. P., Lezeau, S., Attar, E. C., Wu, J. Y., Lin, H. Y., et al. (2012) · Nature Medicine · doi:10.1038/nm.3364 · Cited by 72 · see citing works
Regulation of hematopoietic and leukemic stem cells by the immune system
Riether, C., Schürch, C. M., & Ochsenbein, A. F. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.89 · Cited by 246 · see citing works
Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells
Courties, G., Hérisson, F., Sager, H. B., Heidt, T., Ye, Y., Wei, Y., Sun, Y., Sévère, N., Dutta, P., Scharff, J., et al. (2014) · Circulation Research · doi:10.1161/circresaha.116.305207 · Cited by 240 · see citing works
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Schneider, R. K., Schenone, M., Ferreira, M. S. V., Kramann, R., Joyce, C. E., Hartigan, C. R., Beier, F., Brümmendorf, T. H., Germing, U., Platzbecker, U., et al. (2016) · Nature Medicine · doi:10.1038/nm.4047 · Cited by 236 · see citing works
IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets
Ünver, N., & McAllister, F. M. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.04.004 · Cited by 236 · see citing works
An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis
Abegunde, S. O., Buckstein, R., Wells, R. A., & Rauh, M. J. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2017.11.002 · Cited by 230 · see citing works
Bharti, R., Dey, G., & Mandal, M. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.02.048 · Cited by 227 · see citing works
Schürch, C. M., Riether, C., & Ochsenbein, A. F. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.002 · Cited by 213 · see citing works
Mirantes, C., Passegué, E., & Pietras, E. M. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.017 · Cited by 211 · see citing works
Self-citationMyeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
Hérault, A., Binnewies, M., Leong, S., Calero‐Nieto, F. J., Zhang, S. Y., Kang, Y.-A., Wang, X., Pietras, E. M., Chu, S. H., Barry-Holson, K. Q., et al. (2017) · Nature · doi:10.1038/nature21693 · Cited by 207 · see citing works
Self-citationMullally, A., Bruedigam, C., Poveromo, L., Heidel, F. H., Purdon, A. S., Vu, T., Austin, R. J., Heckl, D., Breyfogle, L. J., Kuhn, C. P., et al. (2013) · Blood · doi:10.1182/blood-2012-05-432989 · Cited by 189 · see citing works
Wang, Y., Zhang, Z., Chi, Y., Zhang, Q., Xu, F., Yang, Z., Meng, L., Yang, S., Yan, S., Mao, A., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.480 · Cited by 185 · see citing works
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
Minciacchi, V. R., Kumar, R., & Krause, D. S. (2021) · Cells · doi:10.3390/cells10010117 · Cited by 184 · see citing works
Agarwal, P., Isringhausen, S., Li, H., Paterson, A. J., He, J., Gomariz, Á., Nagasawa, T., Nombela‐Arrieta, C., & Bhatia, R. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.02.018 · Cited by 177 · see citing works
Koschmieder, S., Mughal, T. I., Hasselbalch, H. C., Barosi, G., Valent, P., Kiladjian, J., Jeryczynski, G., Gisslinger, H., Jutzi, J. S., Pahl, H. L., et al. (2016) · Leukemia · doi:10.1038/leu.2016.12 · Cited by 173 · see citing works
Hematopoietic Stem Cell and Its Bone Marrow Niche
Yu, V. W. C., & Scadden, D. T. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.01.009 · Cited by 162 · see citing works
Clonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161 · see citing works
Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
Cahu, J., Bustany, S., & Sola, B. (2012) · Cell Death & Disease · doi:10.1038/cddis.2012.183 · Cited by 160 · see citing works
Microenvironmental contributions to hematopoietic stem cell aging
Ho, Y., & Méndez‐Ferrer, S. (2019) · Haematologica · doi:10.3324/haematol.2018.211334 · Cited by 149 · see citing works
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors
Henry, C. J., Casás-Selves, M., Kim, J., Zaberezhnyy, V., Aghili, L., Daniel, A. E., Jimenez, L., Azam, T., McNamee, E. N., Clambey, E. T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83024 · Cited by 148 · see citing works
Molecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works
MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
Zhao, J. L., Rao, D. S., O’Connell, R. M., Garcia-Flores, Y., & Baltimore, D. (2013) · eLife · doi:10.7554/elife.00537 · Cited by 135 · see citing works
Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
Reavie, L. B., Buckley, S. M., Loizou, E., Takeishi, S., Aranda-Orgillés, B., Ndiaye‐Lobry, D., Abdel-Wahab, O. I., Ibrahim, S., Nakayama, K. I., & Aifantis, I. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.025 · Cited by 130 · see citing works
Welner, R. S., Amabile, G., Bararia, D., Czibere, A. G., Yang, H. H., Zhang, H., de Figueiredo‐Pontes, L. L., Ye, M., Levantini, E., Ruscio, A. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.004 · Cited by 129 · see citing works
Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity
Cook, E. K., Luo, M., & Rauh, M. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.011 · Cited by 121 · see citing works
Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes
Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L. L., Wilmarth, P. A., Mori, T., Chevillet, J. R., Narla, A., Roberts, C. T., et al. (2015) · Leukemia · doi:10.1038/leu.2015.163 · Cited by 119 · see citing works
Neural regulation of bone and bone marrow
Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114 · see citing works
Brigger, D., Riether, C., van Brummelen, R., Mosher, K. I., Shiu, A., Ding, Z., Bachmeier‐Zbären, N., Gasser, P., Guntern, P., Yousef, H., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0228-3 · Cited by 113 · see citing works
How I treat chronic myelomonocytic leukemia
Solary, É., & Itzykson, R. (2017) · Blood · doi:10.1182/blood-2017-04-736421 · Cited by 112 · see citing works
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
Collins, A., Mitchell, C. A., & Passegué, E. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201545 · Cited by 111 · see citing works
Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
Xiang, M. H., Kim, H. T., Ho, V. T., Walker, S. R., Bar‐Natan, M., Anahtar, M., Liu, S., Toniolo, P. A., Kroll, Y., Jones, N., et al. (2016) · Blood · doi:10.1182/blood-2015-07-660506 · Cited by 109 · see citing works
The hematopoietic stem-cell niche in health and leukemia
Sánchez‐Aguilera, A., & Méndez‐Ferrer, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2306-y · Cited by 105 · see citing works
An evolutionary perspective on chronic myelomonocytic leukemia
Itzykson, R., & Solary, É. (2013) · Leukemia · doi:10.1038/leu.2013.100 · Cited by 102 · see citing works
Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
Hemmati, S., Haque, T. Z., & Gritsman, K. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00265 · Cited by 101 · see citing works
Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases
Chiba, Y., Mizoguchi, I., Hasegawa, H., Ohashi, M., Orii, N., Nagai, T., Sugahara, M., Miyamoto, Y., Xu, M., Owaki, T., et al. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2724-5 · Cited by 99 · see citing works
Made to order: emergency myelopoiesis and demand-adapted innate immune cell production
Swann, J. W., Olson, O. C., & Passegue, E. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00998-7 · Cited by 99 · see citing works
The IL-6 feed-forward loop: A driver of tumorigenesis
Chang, Q., Daly, L., & Bromberg, J. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.007 · Cited by 99 · see citing works
Kesarwani, M., Kincaid, Z., Gomaa, A. R., Huber, E., Rohrabaugh, S., Siddiqui, Z., Bouso, M. F., Latif, T., Xu, M., Komurov, K., et al. (2017) · Nature Medicine · doi:10.1038/nm.4310 · Cited by 98 · see citing works
Gu, Y., Mohammad, I., & Liu, Z. (2020) · Oncology Letters · doi:10.3892/ol.2020.11394 · Cited by 95 · see citing works
Li, J., Kent, D. G., Godfrey, A. L., Manning, H., Nangalia, J., Aziz, A., Chen, E., Saeb‐Parsy, K., Fink, J., Sneade, R., et al. (2014) · Blood · doi:10.1182/blood-2013-06-510222 · Cited by 94 · see citing works
Mitochondrial Transfer in the Leukemia Microenvironment
Griessinger, E., Moschoi, R., Biondani, G., & Peyron, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.10.003 · Cited by 94 · see citing works
Gao, X., Wan, Z., Wei, M., Dong, Y., Zhao, Y., Chen, X., Li, Z., Qin, W., Yang, G., & Liu, L. (2019) · Theranostics · doi:10.7150/thno.34813 · Cited by 94 · see citing works
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
Mager, L. F., Riether, C., Schürch, C. M., Banz, Y., Wasmer, M.-H., Stuber, R., Theocharides, A. P. A., Li, X., Xia, Y., Saito, H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77347 · Cited by 93 · see citing works
FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice
Kode, A., Mosialou, I., Manavalan, S. J., Rathinam, C., Friedman, R. A., Teruya‐Feldstein, J., Bhagat, G., Berman, E., & Kousteni, S. (2015) · Leukemia · doi:10.1038/leu.2015.161 · Cited by 90 · see citing works
The Hematopoietic Stem Cell Niche—Home for Friend and Foe?
Krause, D. S., Scadden, D., & Preffer, F. I. (2012) · Cytometry. Part B, Clinical cytometry · doi:10.1002/cyto.b.21066 · Cited by 84 · see citing works
The cytokine network in acute myeloid leukemia
Luciano, M., Krenn, P. W., & Horejs‐Hoeck, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1000996 · Cited by 89 · see citing works
Regulation of stress-induced hematopoiesis
Zhao, J. L., & Baltimore, D. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000149 · Cited by 88 · see citing works
Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers
Ho, L., Luo, S., & Lai, J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.009 · Cited by 87 · see citing works
Aguilar‐Cázares, D., Chavez-Dominguez, R., Marroquin-Muciño, M., Perez-Medina, M., Benito-Lopez, J. J., Camarena, Á., Rumbo‐Nava, U., & López-González, J. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.929572 · Cited by 85 · see citing works
Mullally, A., Poveromo, L., Schneider, R., Al-Shahrour, F., Lane, S., & Ebert, B. (2012) · Blood · doi:10.1182/blood-2012-01-402396 · Cited by 80 · see citing works
DeGregori, J. V. (2012) · Oncogene · doi:10.1038/onc.2012.281 · Cited by 84 · see citing works
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
Clinical and histopathologic review of Schnitzler syndrome: The Mayo Clinic experience (1972-2011)
Sokumbi, O., Drage, L. A., & Peters, M. S. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.04.027 · Cited by 81 · see citing works
The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment
Greim, H. A., Kaden, D. A., Larson, R. A., Palermo, C. M., Rice, J. M., Ross, D., & Snyder, R. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12362 · Cited by 81 · see citing works
Lee, J.-M., Govindarajah, V., Goddard, B., Hinge, A. S., Muench, D. E., Filippi, M., Aronow, B. J., Cancelas, J. A., Salomonis, N., Grimes, H. L., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170690 · Cited by 81 · see citing works
Self-citationTurning the tide in myelodysplastic/myeloproliferative neoplasms
Deininger, M. W., Tyner, J. W., & Solary, É. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.40 · Cited by 80 · see citing works
Normal Hematopoiesis Is a Balancing Act of Self-Renewal and RegenerationPreprint
Olson, O. C., Kang, Y.-A., & Passegue, E. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035519 · Cited by 78 · see citing works
IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia
Zhang, T. Y., Dutta, R., Benard, B. A., Zhao, F., Yin, R. R., & Majeti, R. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax5104 · Cited by 77 · see citing works
The Multiple Layers of the Tumor Environment
Laplane, L., Duluc, D., Larmonier, N., Pradeu, T., & Bikfalvi, A. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.10.002 · Cited by 74 · see citing works
Dissecting the role of aberrant DNA methylation in human leukaemia
Amabile, G., Ruscio, A. D., Müller, F., Welner, R. S., Yang, H. H., Ebralidze, A. K., Zhang, H., Levantini, E., Qi, L., Martinelli, G., et al. (2015) · Nature Communications · doi:10.1038/ncomms8091 · Cited by 72 · see citing works
Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling
Pollyea, D. A., Harris, C., Rabe, J. L., Hedin, B. R., Arras, L. D., Katz, S., Wheeler, E. C., Bejar, R. L., Walter, M. J., Jordan, C. T., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.214155 · Cited by 72 · see citing works
Self-citationObesity-induced inflammation: The impact of the hematopoietic stem cell niche
Bowers, E., & Singer, K. (2021) · JCI Insight · doi:10.1172/jci.insight.145295 · Cited by 67 · see citing works
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells
Kobayashi, C. I., Takubo, K., Kobayashi, H., Nakamura‐Ishizu, A., Honda, H., Kataoka, K., Kumano, K., Akiyama, H., Sudo, T., Kurokawa, M., et al. (2014) · Blood · doi:10.1182/blood-2013-07-517847 · Cited by 67 · see citing works
CDK6 Inhibition: A Novel Approach in AML Management
Uras, I. Z., Sexl, V., & Kollmann, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072528 · Cited by 65 · see citing works
Naka, K., Jomen, Y., Ishihara, K., Kim, J., Ishimoto, T., Bae, E., Mohney, R. P., Stirdivant, S. M., Oshima, H., Oshima, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9039 · Cited by 63 · see citing works
Lou, Y., He, T., Jiang, F., Shi, J., & Zhu, J. (2014) · Talanta · doi:10.1016/j.talanta.2014.01.016 · Cited by 63 · see citing works
Malengier‐Devlies, B., Metzemaekers, M., Wouters, C. H., Proost, P., & Matthys, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766620 · Cited by 62 · see citing works
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions
Wang, J., Kong, G., Liu, Y., Du, J., Chang, Y., Tey, S.-R., Zhang, X., Ranheim, E. A., Saba-El-Leil, M. K., Meloche, S., et al. (2013) · Blood · doi:10.1182/blood-2012-12-475863 · Cited by 62 · see citing works
Selective elimination of leukemia stem cells: hitting a moving target.
Crews, L., & Jamieson, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.08.006 · Cited by 63 · see citing works
Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms
Hoermann, G., Greiner, G., & Valent, P. (2015) · Mediators of Inflammation · doi:10.1155/2015/869242 · Cited by 61 · see citing works
p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion
Hong, B., Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J. T., Yang, J., & Yi, Q. (2014) · International Journal of Cancer · doi:10.1002/ijc.28958 · Cited by 59 · see citing works
Inflammatory Cytokines Shape an Altered Immune Response During Myeloid Malignancies
Camacho, V., Kuznetsova, V., & Welner, R. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772408 · Cited by 58 · see citing works
Role of STAT3 in Transformation and Drug Resistance in CML
Nair, R. R., Tolentino, J. H. G., & Hazlehurst, L. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00030 · Cited by 56 · see citing works
Bone marrow inflammation in haematological malignancies
de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54 · see citing works
Lyadova, I. V., Gerasimova, T., & Nenasheva, T. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640703 · Cited by 53 · see citing works
Molecular biology of chronic myeloid leukemia
Maru, Y. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02346.x · Cited by 53 · see citing works
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
Kong, G., Wunderlich, M., Yang, D. T., Ranheim, E., Young, K., Wang, J.-Y., Chang, Y.-I., Du, J., Liu, Y., Tey, S., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74182 · Cited by 52 · see citing works
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations
Traer, E. A., Javidi‐Sharifi, N., Agarwal, A., Dunlap, J. B., English, I. A., Martinez, J., Tyner, J. W., Wong, M., & Druker, B. J. (2014) · Blood · doi:10.1182/blood-2013-07-518381 · Cited by 51 · see citing works
Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling
Kuepper, M. K., Bütow, M., Herrmann, O., Ziemons, J., Chatain, N., Maurer, A., Kirschner, M., Maié, T., Costa, I. G., Eschweiler, J., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0427-7 · Cited by 51 · see citing works
Nievergall, E., Reynolds, J., Kok, C. H., Watkins, D. B., Biondo, M., Busfield, S. J., Vairo, G., Fuller, K. A., Erber, W. N., Sadras, T., et al. (2016) · Leukemia · doi:10.1038/leu.2016.34 · Cited by 50 · see citing works
Wang, W., Zimmerman, G., Huang, X., Yu, S., Myers, J., Wang, Y., Moreton, S. A., Nthale, J. M., Awadallah, A., Beck, R. C., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2092 · Cited by 50 · see citing works
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner
Peña‐Martínez, P., Eriksson, M. D., Ramakrishnan, R., Chapellier, M., Högberg, C., Orsmark‐Pietras, C., Richter, J., Andersson, A., Fioretos, T., & Järås, M. (2017) · Leukemia · doi:10.1038/leu.2017.261 · Cited by 49 · see citing works
Lai, D., Chen, M., Su, J., Liu, X., Rothe, K., Hu, K., Forrest, D. L., Eaves, C. J., Morin, G. B., & Jiang, X. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan8735 · Cited by 47 · see citing works
- Authors
- Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J. P., & Passegué, E.
- Affiliations
- University of California, San Francisco (US)
- Standard BioTools (United States) (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Reynaud, Damien
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 20
- Issue
- 5
- Pages
- 661-673
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3220886
- OpenAlex
- W1974815398
- Cited by
- 335
- References
- 34
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 17 · 2023: 26 · 2022: 26 · 2021: 33 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 25 · 2016: 20 · 2015: 28 · 2014: 24 · 2013: 19 · 2012: 16
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University of California, San Francisco
- National Heart, Lung, and Blood Institute (HL092471, R01HL092471)
- Topics
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- interleukin-6, chronic myeloid leukemia, multipotent progenitors, leukemia stem cells, long-term hematopoietic stem cells, BCR-ABL, myeloid differentiation, paracrine signaling, cell fate specification
- MeSH terms
- Animals, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Interleukin-6, Fusion Proteins, bcr-abl, Feedback, Physiological, Multipotent Stem Cells, Mice, Precursor Cells, B-Lymphoid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
